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Lab NCD code-list changes, October 2025 to October 2026

The 23 Medicare laboratory National Coverage Determinations each carry a national ICD-10-CM edit list. This report compares the three lists CMS has published since October 2025, code by code: the January 2026 release added 432 codes and removed none, and the October 2026 release added 46 and removed 33, almost all of them because of the FY2027 ICD-10-CM update.

Compiled from CMS files by the QuickIntell RCM Editorial Team · Data effective · Method: reference methodology · Report a data correction

Data currency: Lab NCD code lists: October 2026 (effective October 1, 2026); ICD-10-CM code descriptions: FY2027 (effective October 1, 2026). Next CMS release: January 1, 2027 (quarterly update) for the Lab NCD code lists; FY2028 code files, effective October 1, 2027 for the ICD-10-CM code descriptions.

Headline numbers

January 2026: codes added
432
331 covered, 101 not supporting necessity
January 2026: codes removed
0
18 NCDs changed
October 2026: codes added
46
43 covered, 3 not supporting necessity
October 2026: codes removed
33
10 NCDs changed
Removed codes deleted from ICD-10-CM
32
of 33 removed in October 2026
Releases compared
3
October 2025, January 2026, October 2026

List size by NCD and release

Each count is the number of ICD-10-CM codes on the NCD's list in that release, after removing rows whose term date falls before the release takes effect. Lists that grew between October 2025 and January 2026 mostly gained covered codes; the October 2026 column reflects the FY2027 code changes. Each NCD links to its reference page, which now shows what changed in its own list.

ICD-10-CM codes on each laboratory NCD list by release
NCDTitleOctober 2025January 2026October 2026Added / removed in October 2026
190.12Urine Culture, Bacterial986997997+0 / −0
190.13Human Immunodeficiency Virus (HIV)Testing (Prognosis Including Monitoring)255255255+0 / −0
190.14Human Immunodeficiency Virus (HIV) Testing (Diagnosis)1,2941,2981,301+5 / −2
190.15Blood Counts22,39422,49522,491+3 / −7
190.16Partial Thromboplastin Time (PTT)6,4826,5176,518+2 / −1
190.17Prothrombin Time (PT)7,4697,5047,506+10 / −8
190.18Serum Iron Studies3,4973,5073,512+10 / −5
190.19Collagen Crosslinks, Any Method522522522+0 / −0
190.20Blood Glucose Testing2,6962,8082,810+3 / −1
190.21Glycated Hemoglobin/Glycated Protein788836836+0 / −0
190.22Thyroid Testing1,6201,6371,639+3 / −1
190.23Lipids Testing1,9431,9481,948+0 / −0
190.24Digoxin Therapeutic Drug Assay637637642+8 / −3
190.25Alpha-fetoprotein386388388+0 / −0
190.26Carcinoembryonic Antigen426428428+0 / −0
190.27Human Chorionic Gonadotropin409411411+0 / −0
190.28Tumor Antigen by Immunoassay CA 125280286286+0 / −0
190.29Tumor Antigen by Immunoassay CA 15-3/CA 27.29304306306+0 / −0
190.30Tumor Antigen by Immunoassay CA 19-9261261261+0 / −0
190.31Prostate Specific Antigen284284284+0 / −0
190.32Gamma Glutamyl Transferase4,1414,1704,166+0 / −4
190.33Hepatitis Panel/Acute Hepatitis Panel412420420+0 / −0
190.34Fecal Occult Blood Test1,3791,3821,383+2 / −1

October 2026: 46 codes added, 33 removed

The FY2027 ICD-10-CM update took effect on October 1, 2026 and deleted codes that the lab lists carried, so CMS term-dated them on September 30, 2026 and listed the new, more specific codes in their place. 32 of the 33 removals are such deletions, and 46 of the 46 additions are the replacement codes the FY2027 conversion table lists for a code removed from the same NCD; C75.9 on NCD 190.18 was removed while the code itself remains valid in FY2027. A claim with a date of service on or after October 1 must carry the FY2027 code.

ICD-10-CM codes added to laboratory NCD lists, October 2026
NCDICD-10-CMFY2027 descriptionResult
190.14I42.00Dilated cardiomyopathy, unspecifiedcovered
190.14I42.01Familial-genetic dilated cardiomyopathycovered
190.14I42.09Other dilated cardiomyopathycovered
190.14I42.81Arrhythmogenic cardiomyopathycovered
190.14I42.89Other cardiomyopathies not elsewhere classifiedcovered
190.15M72.20Plantar fascial fibromatosis, unspecified footdoes not support medical necessity
190.15M72.21Plantar fascial fibromatosis, right footdoes not support medical necessity
190.15M72.22Plantar fascial fibromatosis, left footdoes not support medical necessity
190.16D69.11Glanzmann thrombastheniacovered
190.16D69.19Other qualitative platelet defectscovered
190.17D69.11Glanzmann thrombastheniacovered
190.17D69.19Other qualitative platelet defectscovered
190.17I42.00Dilated cardiomyopathy, unspecifiedcovered
190.17I42.01Familial-genetic dilated cardiomyopathycovered
190.17I42.09Other dilated cardiomyopathycovered
190.17I42.81Arrhythmogenic cardiomyopathycovered
190.17I42.89Other cardiomyopathies not elsewhere classifiedcovered
190.17I49.81Brugada syndromecovered
190.17I49.82Ventricular bigeminycovered
190.17I49.89Other specified cardiac arrhythmias not elsewhere classifiedcovered
190.18D69.11Glanzmann thrombastheniacovered
190.18D69.19Other qualitative platelet defectscovered
190.18I42.00Dilated cardiomyopathy, unspecifiedcovered
190.18I42.01Familial-genetic dilated cardiomyopathycovered
190.18I42.09Other dilated cardiomyopathycovered
190.18I42.81Arrhythmogenic cardiomyopathycovered
190.18I42.89Other cardiomyopathies not elsewhere classifiedcovered
190.18I49.81Brugada syndromecovered
190.18I49.82Ventricular bigeminycovered
190.18I49.89Other specified cardiac arrhythmias not elsewhere classifiedcovered
190.20M86.8X71Other osteomyelitis, right ankle and footcovered
190.20M86.8X72Other osteomyelitis, left ankle and footcovered
190.20M86.8X79Other osteomyelitis, unspecified ankle and footcovered
190.22I49.81Brugada syndromecovered
190.22I49.82Ventricular bigeminycovered
190.22I49.89Other specified cardiac arrhythmias not elsewhere classifiedcovered
190.24I42.00Dilated cardiomyopathy, unspecifiedcovered
190.24I42.01Familial-genetic dilated cardiomyopathycovered
190.24I42.09Other dilated cardiomyopathycovered
190.24I42.81Arrhythmogenic cardiomyopathycovered
190.24I42.89Other cardiomyopathies not elsewhere classifiedcovered
190.24I49.81Brugada syndromecovered
190.24I49.82Ventricular bigeminycovered
190.24I49.89Other specified cardiac arrhythmias not elsewhere classifiedcovered
190.34D69.11Glanzmann thrombastheniacovered
190.34D69.19Other qualitative platelet defectscovered

Removed codes with their last description, the term date on the list and, for codes the FY2027 update deleted, the codes that replaced them in ICD-10-CM.

ICD-10-CM codes removed from laboratory NCD lists, October 2026
NCDICD-10-CMDescriptionTerm dateFY2027 replacement codes
190.14I42.0Dilated cardiomyopathy2026-09-30I42.00, I42.01, I42.09
190.14I42.8Other cardiomyopathies2026-09-30I42.81, I42.89
190.15M72.2Plantar fascial fibromatosis2026-09-30M67.A01, M67.A02, M67.A09, M72.20, M72.21, M72.22
190.15S23.420ASprain of sternoclavicular (joint) (ligament), initial encounter2026-09-30deleted, no replacement listed
190.15S23.420SSprain of sternoclavicular (joint) (ligament), sequela2026-09-30deleted, no replacement listed
190.15T52.8X1SToxic effect of other organic solvents, accidental (unintentional), sequela2026-09-30T52.811S, T52.821S, T52.891S
190.15T52.8X2SToxic effect of other organic solvents, intentional self-harm, sequela2026-09-30T52.812S, T52.822S, T52.892S
190.15T52.8X3SToxic effect of other organic solvents, assault, sequela2026-09-30T52.813S, T52.823S, T52.893S
190.15T52.8X4SToxic effect of other organic solvents, undetermined, sequela2026-09-30T52.814S, T52.824S, T52.894S
190.16D69.1Qualitative platelet defects2026-09-30D69.11, D69.19
190.17D69.1Qualitative platelet defects2026-09-30D69.11, D69.19
190.17I42.0Dilated cardiomyopathy2026-09-30I42.00, I42.01, I42.09
190.17I42.8Other cardiomyopathies2026-09-30I42.81, I42.89
190.17I49.8Other specified cardiac arrhythmias2026-09-30G90.A, I49.81, I49.82, I49.89
190.17T52.8X1AToxic effect of other organic solvents, accidental (unintentional), initial encounter2026-09-30T52.811A, T52.821A, T52.891A
190.17T52.8X2AToxic effect of other organic solvents, intentional self-harm, initial encounter2026-09-30T52.812A, T52.822A, T52.892A
190.17T52.8X3AToxic effect of other organic solvents, assault, initial encounter2026-09-30T52.813A, T52.823A, T52.893A
190.17T52.8X4AToxic effect of other organic solvents, undetermined, initial encounter2026-09-30T52.814A, T52.824A, T52.894A
190.18C75.9Malignant neoplasm of endocrine gland, unspecified2026-09-30code still valid
190.18D69.1Qualitative platelet defects2026-09-30D69.11, D69.19
190.18I42.0Dilated cardiomyopathy2026-09-30I42.00, I42.01, I42.09
190.18I42.8Other cardiomyopathies2026-09-30I42.81, I42.89
190.18I49.8Other specified cardiac arrhythmias2026-09-30G90.A, I49.81, I49.82, I49.89
190.20M86.8X7Other osteomyelitis, ankle and foot2026-09-30M86.8X71, M86.8X72, M86.8X79
190.22I49.8Other specified cardiac arrhythmias2026-09-30G90.A, I49.81, I49.82, I49.89
190.24I42.0Dilated cardiomyopathy2026-09-30I42.00, I42.01, I42.09
190.24I42.8Other cardiomyopathies2026-09-30I42.81, I42.89
190.24I49.8Other specified cardiac arrhythmias2026-09-30G90.A, I49.81, I49.82, I49.89
190.32T52.8X1AToxic effect of other organic solvents, accidental (unintentional), initial encounter2026-09-30T52.811A, T52.821A, T52.891A
190.32T52.8X2AToxic effect of other organic solvents, intentional self-harm, initial encounter2026-09-30T52.812A, T52.822A, T52.892A
190.32T52.8X3AToxic effect of other organic solvents, assault, initial encounter2026-09-30T52.813A, T52.823A, T52.893A
190.32T52.8X4AToxic effect of other organic solvents, undetermined, initial encounter2026-09-30T52.814A, T52.824A, T52.894A
190.34D69.1Qualitative platelet defects2026-09-30D69.11, D69.19

January 2026: 432 codes added, none removed

The January 2026 release only added codes. 331 were added as covered diagnoses across 18 NCDs, and 101 were added to NCD 190.15 (blood counts) as codes that do not support medical necessity; 190.15 works by exclusion, so those additions narrow what the blood-count NCD pays for. No code was removed and none changed its result.

Additions per NCD by result. The 432 codes, with their FY2027 descriptions, are in the CSV download.

ICD-10-CM codes added to each laboratory NCD list, January 2026
NCDTitleCoveredNot supporting necessityNon-covered
190.12Urine Culture, Bacterial1100
190.14Human Immunodeficiency Virus (HIV) Testing (Diagnosis)400
190.15Blood Counts01010
190.16Partial Thromboplastin Time (PTT)3500
190.17Prothrombin Time (PT)3500
190.18Serum Iron Studies1000
190.20Blood Glucose Testing11200
190.21Glycated Hemoglobin/Glycated Protein4800
190.22Thyroid Testing1700
190.23Lipids Testing500
190.25Alpha-fetoprotein200
190.26Carcinoembryonic Antigen200
190.27Human Chorionic Gonadotropin200
190.28Tumor Antigen by Immunoassay CA 125600
190.29Tumor Antigen by Immunoassay CA 15-3/CA 27.29200
190.32Gamma Glutamyl Transferase2900
190.33Hepatitis Panel/Acute Hepatitis Panel800
190.34Fecal Occult Blood Test300

What to check

Confirm that the claim scrubber and any order-entry diagnosis pick lists use the October 2026 lists for dates of service from October 1, 2026; a scrubber still on the January 2026 lists accepts deleted ICD-10-CM codes that the contractor now rejects. For outpatient laboratory orders likely to fail the edit, an advance beneficiary notice is the usual protection; the NCD pages explain the denial codes that follow a failed edit.

Every laboratory NCD is on the Medicare coverage reference, the guide to National Coverage Determinations explains how the lab edit lists work.

Method

Each release is read from the section 508 version of the CMS laboratory NCD ICD-10 spreadsheet: asterisks that mark changed cells are stripped, rows whose ICD-10 term date falls before the release's effective date are dropped, and the wildcard row for unlisted codes is set aside. Lists are compared per NCD by ICD-10-CM code and resolution. Descriptions come from the FY2027 ICD-10-CM files, and replacements of deleted codes from the FY2027 conversion table. See the reference methodology.

Part of the Lab NCD quarterly changes series, rebuilt from each CMS release. Next edition: the next quarterly lab NCD list CMS posts. Earlier and later editions are listed on the research index.

Download the full table

The CSV holds every ICD-10-CM code added, removed or re-resolved on a laboratory NCD list from October 2025 to October 2026: 511 rows, one header row and the columns releases, ncd, ncd title, change, icd10 cm, fy2027 description, resolution, previous resolution, term date, fy2027 replaced by. Its first line is a comment that names each CMS source file with its SHA-256, the data date and the attribution line to keep when you reuse the table.

Download CSV (511 rows)

Table SHA-256 (the rows after the comment line): 2005bee346d65d7b61fe2e554bb982c2576d842d3d9fcd15bbd58b0f2f0d5111. Data as of 2026-10-01.

Where QuickIntell fits in coverage checks

QuickAuth coordinates requirement checks, documentation, submission and status tracking for prior authorization with human review, so national and local coverage criteria are looked at before the service. QuickRCM picks up the claim and any coverage denial afterwards.

Frequently asked questions

What changed in the October 2026 lab NCD code lists?

CMS added 46 ICD-10-CM codes and removed 33 across 10 of the 23 laboratory NCDs. 32 of the removed codes are codes the FY2027 ICD-10-CM update deleted on October 1, 2026, and 46 of the 46 added codes are their FY2027 replacements on the same list.

Did the lab NCD lists lose codes in January 2026?

No. The January 2026 release only added codes: 432 in total, 331 as covered and 101 as codes that do not support medical necessity. None were removed and no code changed its coverage result.

Why are there no April or July 2026 lists?

CMS posted no laboratory NCD code list for April or July 2026, so the January 2026 lists were the current ones until the October 2026 release.

How does a lab NCD list affect a claim?

Medicare contractors run the national edit automatically: a claim line for one of the NCD's procedure codes is paid only when the claim carries a diagnosis the list covers, and is denied when every diagnosis is non-covered or does not support medical necessity. A code removed from a covered list stops supporting payment for dates of service after its term date.

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-10. Verify against the primary file before billing or contracting decisions. The reference methodology explains how each figure is computed from these files.

Disclaimer

ICD-10-CM codes and descriptions are public domain. Procedure codes on the lab NCD pages appear as numbers only. Operational reference, not legal, clinical or billing advice.

Found a figure that does not match the CMS file? Report a data correction with the CMS file and the value you expected; the request reaches the editorial team through the contact form.