Skip to main content
Call AIBook a demo

ICD-10-CM D57.458: Sickle-cell thalassemia beta plus with crisis with other specified complication

D57.458 is the billable ICD-10-CM code for sickle-cell thalassemia beta plus with crisis with other specified complication, in category D57 (Sickle-cell disorders) of the Hemolytic anemias section. As a principal diagnosis it groups to MS-DRG 791 Prematurity with Major Problems, MS-DRG 793 Full Term Neonate with Major Problems (MDC 15 MDC 15: Newborns and Other Neonates with Conditions Originating in Perinatal Period); or MS-DRG 811 Red Blood Cell Disorders with MCC, MS-DRG 812 Red Blood Cell Disorders without MCC (MDC 16 MDC 16: Diseases and Disorders of Blood, Blood Forming Organs and Immunologic Disorders). It maps to HCC 108 (Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major) in CMS-HCC V28. As a secondary diagnosis it is an MCC, excluded with 51 principal diagnoses. 14 LCD billing and coding articles list it as covered.

Compiled from CMS files by the QuickIntell RCM Editorial Team · Data effective · Method: reference methodology · Report a data correction

Data currency: ICD-10-CM code descriptions: FY2027 (effective October 1, 2026); IPPS Table 5 (MS-DRG weights): v44 FY2027 (final rule + CN3) (effective October 1, 2026); ICD-10-CM to HCC mapping: PY2027 initial ICD-10-CM mappings (dates of service 2026) (payment year 2027); Medicare Coverage Database billing and coding articles: MCD release October 8, 2026 (effective October 4, 2026). Next CMS release: FY2028 code files, effective October 1, 2027 for the ICD-10-CM code descriptions; FY2028 final rule (August 2027), effective October 1, 2027; an April 1 interim grouper update when CMS issues one for the IPPS Table 5 (MS-DRG weights); PY2028 advance notice (February 2027) and the PY2027 midyear final mapping (spring 2027) for the ICD-10-CM to HCC mapping; weekly, every Thursday for the Medicare Coverage Database billing and coding articles.

Code
D57.458
billable FY2027 ICD-10-CM code
Category
D57 Sickle-cell disorders
Chapter
3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
CC/MCC (MS-DRG v44)
MCC
CMS-HCC V28
HCC 108
POA reporting
Required

Tabular list notes for D57.458

The tabular list has no notes on D57.458 itself; the notes below apply from its parent headings.

Inherited from D57 (Sickle-cell disorders)

Excludes1 (never coded together)
  • other hemoglobinopathies (D58.-)
Use additional code
  • code for any associated fever (R50.81)

Inherited from D57.4 (Sickle-cell thalassemia)

Inclusion terms
  • Sickle-cell beta thalassemia
  • Thalassemia Hb-S disease

Inherited from D57.45 (Sickle-cell thalassemia beta plus with crisis)

Inclusion terms
  • HbS-beta plus with crisis
  • Sickle-cell beta plus with crisis

MS-DRG grouping when D57.458 is the principal diagnosis

MS-DRG v44 groups for D57.458 as principal diagnosis
MDCMS-DRGs
15 MDC 15: Newborns and Other Neonates with Conditions Originating in Perinatal Period791793
16 MDC 16: Diseases and Disorders of Blood, Blood Forming Organs and Immunologic Disorders811812

The final group also depends on procedures, secondary diagnoses and discharge status; the MS-DRG lookup for D57.458 shows the full grouping logic.

CC/MCC status and inpatient edits

As a secondary diagnosis, D57.458 is an MCC under MS-DRG v44, unless the principal diagnosis is one of the 51 codes in its exclusion list. Check D57.458 against a principal diagnosis.

  • Present on admission: a POA indicator is required on inpatient claims.

CMS-HCC V28 risk adjustment

In the PY2027 mapping, D57.458 maps to HCC 108 (Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major). The HCC lookup shows the RAF weight and the hierarchy.

LCD billing and coding articles that list D57.458

14 current Medicare billing and coding articles list D57.458 among the diagnoses that support medical necessity for the services they cover.

For teams evaluating QuickIntell software

Evaluate software for diagnosis coding review

If your team codes diagnoses at volume, review how QuickCode supports qualified coder review of documentation, specificity queries and the billing handoff. Confirm the code sets, settings and reviewer responsibilities during evaluation; a code reference is not a coding determination for a patient.

Evaluate QuickCode for diagnosis codingSee risk adjustment review
Book a software demoAsk about a software workflow

Optional software evaluation, not payer support or help with an individual claim. For coverage or payment decisions, use the official sources on this page. Do not include patient information in a demo booking or inquiry.

Frequently asked questions

What does ICD-10-CM D57.458 mean?

D57.458 means sickle-cell thalassemia beta plus with crisis with other specified complication. It is one of 25 billable codes under D57, sickle-cell disorders.

Which MS-DRG does D57.458 group to?

As the principal diagnosis, D57.458 groups to MS-DRG 791 Prematurity with Major Problems, MS-DRG 793 Full Term Neonate with Major Problems (MDC 15 MDC 15: Newborns and Other Neonates with Conditions Originating in Perinatal Period); or MS-DRG 811 Red Blood Cell Disorders with MCC, MS-DRG 812 Red Blood Cell Disorders without MCC (MDC 16 MDC 16: Diseases and Disorders of Blood, Blood Forming Organs and Immunologic Disorders) under MS-DRG v44, before procedures and secondary diagnoses are applied.

Does D57.458 map to an HCC?

Yes: HCC 108, Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major, in the PY2027 CMS-HCC V28 mapping.

Is D57.458 a CC or MCC?

D57.458 is an MCC under MS-DRG v44; 51 principal diagnoses exclude it.

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-10. Verify against the primary file before billing or contracting decisions. The reference methodology explains how each figure is computed from these files.

Disclaimer

The descriptor and notes are reproduced from the FY2027 ICD-10-CM files; MS-DRG, CC/MCC and HCC facts come from the CMS FY2027 and PY2027 tables. Code from the medical record and the ICD-10-CM Official Guidelines. Not legal, clinical or billing advice.

Found a figure that does not match the CMS file? Report a data correction with the CMS file and the value you expected; the request reaches the editorial team through the contact form.