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HCC 108: Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major

HCC 108, Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major, is one of the 115 payment categories in the CMS-HCC V28 model. 39 ICD-10-CM codes map to it in the payment year 2027 mapping, and a documented diagnosis in the category adds a relative factor of 0.146 to the risk score of a community, non-dual, aged beneficiary (0.386 disabled, 0.098 institutional). It is overridden when a more severe category in its hierarchy is present (HCC 107).

QuickIntell editorial content · Legacy registry date · Review not verified

Data effective
Data currency: ICD-10-CM to HCC mapping PY2027 initial (effective dates of service 2026, payment year 2027); CMS-HCC V28 model software V2826.115.T2 (effective payment year 2027). Next CMS release: PY2027 midyear final mapping (spring 2027) and PY2028 proposed model (February 2027).
Mapped ICD-10-CM codes
39
Factor, community non-dual aged
0.146
Factor, institutional
0.098
Hierarchy
Overridden by HCC 107

Relative factors by segment

Each segment is a separate regression; the factor is added to the beneficiary's demographic factors and other categories, then normalized and reduced by the coding intensity adjustment before it meets the plan's base rate. A factor of 1.000 equals the expected cost of an average beneficiary.

CMS-HCC V28 relative factors for HCC 108 by model segment
SegmentModel codeRelative factor
Community, non-dual, agedCNA_HCC1080.146
Community, non-dual, disabledCND_HCC1080.386
Community, full-benefit dual, agedCFA_HCC1080.103
Community, full-benefit dual, disabledCFD_HCC1080.408
Community, partial-benefit dual, agedCPA_HCC1080.303
Community, partial-benefit dual, disabledCPD_HCC1080.416
Long-term institutionalINS_HCC1080.098

Hierarchy

Hierarchical condition categories pay only the most severe manifestation of a disease. When HCC 107 (Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero) is also documented for the same beneficiary, HCC 108 is dropped from the score.

ICD-10-CM codes that map to HCC 108

39 codes map to this category in the PY2027 initial mapping, concentrated in the D57 (28), H36 (8), D56 (3) code families. Descriptions are the CMS mapping descriptions for the FY2026 code set; a code that is deleted or split in the October code update stays valid for dates of service before the change.

ICD-10-CM codes mapped to HCC 108 in the CMS PY2027 initial mapping
ICD-10-CMDescription
D561Beta thalassemia
D562Delta-beta thalassemia
D565Hemoglobin E-beta thalassemia
D5720Sickle-cell/Hb-C disease without crisis
D57211Sickle-cell/Hb-C disease with acute chest syndrome
D57212Sickle-cell/Hb-C disease with splenic sequestration
D57213Sickle-cell/Hb-C disease with cerebral vascular involvement
D57214Sickle-cell/Hb-C disease with dactylitis
D57218Sickle-cell/Hb-C disease with crisis with other specified complication
D57219Sickle-cell/Hb-C disease with crisis, unspecified
D5740Sickle-cell thalassemia without crisis
D57411Sickle-cell thalassemia, unspecified, with acute chest syndrome
D57412Sickle-cell thalassemia, unspecified, with splenic sequestration
D57413Sickle-cell thalassemia, unspecified, with cerebral vascular involvement
D57414Sickle-cell thalassemia, unspecified, with dactylitis
D57418Sickle-cell thalassemia, unspecified, with crisis with other specified complication
D57419Sickle-cell thalassemia, unspecified, with crisis
D5744Sickle-cell thalassemia beta plus without crisis
D57451Sickle-cell thalassemia beta plus with acute chest syndrome
D57452Sickle-cell thalassemia beta plus with splenic sequestration
D57453Sickle-cell thalassemia beta plus with cerebral vascular involvement
D57454Sickle-cell thalassemia beta plus with dactylitis
D57458Sickle-cell thalassemia beta plus with crisis with other specified complication
D57459Sickle-cell thalassemia beta plus with crisis, unspecified
D5780Other sickle-cell disorders without crisis
D57811Other sickle-cell disorders with acute chest syndrome
D57812Other sickle-cell disorders with splenic sequestration
D57813Other sickle-cell disorders with cerebral vascular involvement
D57814Other sickle-cell disorders with dactylitis
D57818Other sickle-cell disorders with crisis with other specified complication
D57819Other sickle-cell disorders with crisis, unspecified
H36811Nonproliferative sickle-cell retinopathy, right eye
H36812Nonproliferative sickle-cell retinopathy, left eye
H36813Nonproliferative sickle-cell retinopathy, bilateral
H36819Nonproliferative sickle-cell retinopathy, unspecified eye
H36821Proliferative sickle-cell retinopathy, right eye
H36822Proliferative sickle-cell retinopathy, left eye
H36823Proliferative sickle-cell retinopathy, bilateral
H36829Proliferative sickle-cell retinopathy, unspecified eye

Where these codes sat in the V22 model

The V28 recalibration renumbered and regrouped categories; this table shows which legacy V22 categories the same ICD-10 codes belonged to, which is the quickest way to reconcile a V22-era HCC gap list with the current model.

V22 categories that the HCC 108 codes mapped to
V22 HCCCodes
4636
483

Capturing and defending the category

A category counts for a payment year when a mapped diagnosis is documented at least once during the data collection year by an acceptable provider type at a face-to-face or audio-video encounter, and when the note shows the condition was monitored, evaluated, assessed or treated. Chronic conditions do not carry forward: a category that is not re-documented in the year drops out of the score, which is why annual wellness visits and problem-list reconciliation are where most recapture happens. Risk adjustment data validation audits sample enrollees and ask for the medical record behind each submitted category; an unsupported category is removed and, under the extrapolation rules, the error rate is applied across the contract. The QuickIntell risk adjustment product surfaces suspected and unsupported categories from the chart, and the HCC hub lists every V28 category with its factor and code count.

Frequently asked questions

Which ICD-10 codes map to HCC 108?

39 ICD-10-CM codes map to HCC 108 in the CMS PY2027 initial mapping, for example D561 Beta thalassemia; D562 Delta-beta thalassemia; D565 Hemoglobin E-beta thalassemia; D5720 Sickle-cell/Hb-C disease without crisis. The full list is on this page; a code counts only when it is documented at a face-to-face or video encounter in the data collection year and supported by the record.

How much does HCC 108 add to a risk score?

The V28 relative factor for HCC 108 is 0.146 for a community, non-dual, aged beneficiary, 0.103 for full-benefit dual aged, 0.386 for non-dual disabled and 0.098 for long-term institutional members. A factor of 1.000 equals the expected annual cost of an average beneficiary, so the category's share of the payment follows the plan's base rate for that segment.

Does HCC 108 count together with related categories?

No. Within a hierarchy only the most severe category is paid. HCC 108 is dropped when HCC 107 (Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero) is also present.

What has to be documented for HCC 108 to be valid?

The diagnosis must be recorded by an acceptable provider type during a face-to-face or audio-video encounter in the service year, with the note showing that the condition was monitored, evaluated, assessed or treated. Risk adjustment data validation audits recover payment for categories the record does not support, so the code on the claim and the assessment in the note must match.

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-02. Verify against the primary file before billing or contracting decisions.

Disclaimer

Relative factors and mappings are reproduced from the CMS risk adjustment model files as an operational reference. Payment depends on the plan's base rate, normalization, the coding intensity adjustment and the enrollee's segment. Not legal, clinical or billing advice.