Skip to main content
Call AIBook a demo

ICD-10-CM category D57: Sickle-cell disorders

Category D57 is a heading in chapter 3 (Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)), section Hemolytic anemias (D55-D59). It is not billable; report one of the 43 complete codes below.

Notes that apply to every D57 code

Excludes1 (never coded together)
  • other hemoglobinopathies (D58.-)
Use additional code
  • code for any associated fever (R50.81)

Billable codes in D57

Billable FY2027 ICD-10-CM codes in category D57
CodeDescription
D57.00Hb-SS disease with crisis, unspecified
D57.01Hb-SS disease with acute chest syndrome
D57.02Hb-SS disease with splenic sequestration
D57.03Hb-SS disease with cerebral vascular involvement
D57.04Hb-SS disease with dactylitis
D57.09Hb-SS disease with crisis with other specified complication
D57.1Sickle-cell disease without crisis
D57.20Sickle-cell/Hb-C disease without crisis
D57.211Sickle-cell/Hb-C disease with acute chest syndrome
D57.212Sickle-cell/Hb-C disease with splenic sequestration
D57.213Sickle-cell/Hb-C disease with cerebral vascular involvement
D57.214Sickle-cell/Hb-C disease with dactylitis
D57.218Sickle-cell/Hb-C disease with crisis with other specified complication
D57.219Sickle-cell/Hb-C disease with crisis, unspecified
D57.3Sickle-cell trait
D57.40Sickle-cell thalassemia without crisis
D57.411Sickle-cell thalassemia, unspecified, with acute chest syndrome
D57.412Sickle-cell thalassemia, unspecified, with splenic sequestration
D57.413Sickle-cell thalassemia, unspecified, with cerebral vascular involvement
D57.414Sickle-cell thalassemia, unspecified, with dactylitis
D57.418Sickle-cell thalassemia, unspecified, with crisis with other specified complication
D57.419Sickle-cell thalassemia, unspecified, with crisis
D57.42Sickle-cell thalassemia beta zero without crisis
D57.431Sickle-cell thalassemia beta zero with acute chest syndrome
D57.432Sickle-cell thalassemia beta zero with splenic sequestration
D57.433Sickle-cell thalassemia beta zero with cerebral vascular involvement
D57.434Sickle-cell thalassemia beta zero with dactylitis
D57.438Sickle-cell thalassemia beta zero with crisis with other specified complication
D57.439Sickle-cell thalassemia beta zero with crisis, unspecified
D57.44Sickle-cell thalassemia beta plus without crisis
D57.451Sickle-cell thalassemia beta plus with acute chest syndrome
D57.452Sickle-cell thalassemia beta plus with splenic sequestration
D57.453Sickle-cell thalassemia beta plus with cerebral vascular involvement
D57.454Sickle-cell thalassemia beta plus with dactylitis
D57.458Sickle-cell thalassemia beta plus with crisis with other specified complication
D57.459Sickle-cell thalassemia beta plus with crisis, unspecified
D57.80Other sickle-cell disorders without crisis
D57.811Other sickle-cell disorders with acute chest syndrome
D57.812Other sickle-cell disorders with splenic sequestration
D57.813Other sickle-cell disorders with cerebral vascular involvement
D57.814Other sickle-cell disorders with dactylitis
D57.818Other sickle-cell disorders with crisis with other specified complication
D57.819Other sickle-cell disorders with crisis, unspecified

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-10. Verify against the primary file before billing or contracting decisions. The reference methodology explains how each figure is computed from these files.

Codes from the FY2027 ICD-10-CM files (all chapters). Report the code that matches the documentation and the Official Guidelines; this list is not coding advice.