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ICD-10-CM D57.1: Sickle-cell disease without crisis

D57.1 is the billable ICD-10-CM code for sickle-cell disease without crisis, in category D57 (Sickle-cell disorders) of the Hemolytic anemias section. As a principal diagnosis it groups to MS-DRG 811 Red Blood Cell Disorders with MCC, MS-DRG 812 Red Blood Cell Disorders without MCC (MDC 16 MDC 16: Diseases and Disorders of Blood, Blood Forming Organs and Immunologic Disorders). It maps to HCC 107 (Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero) in CMS-HCC V28. 21 LCD billing and coding articles list it as covered.

Compiled from CMS files by the QuickIntell RCM Editorial Team · Data effective · Method: reference methodology · Report a data correction

Data currency: ICD-10-CM code descriptions: FY2027 (effective October 1, 2026); IPPS Table 5 (MS-DRG weights): v44 FY2027 (final rule + CN3) (effective October 1, 2026); ICD-10-CM to HCC mapping: PY2027 initial ICD-10-CM mappings (dates of service 2026) (payment year 2027); Medicare Coverage Database billing and coding articles: MCD release October 8, 2026 (effective October 4, 2026). Next CMS release: FY2028 code files, effective October 1, 2027 for the ICD-10-CM code descriptions; FY2028 final rule (August 2027), effective October 1, 2027; an April 1 interim grouper update when CMS issues one for the IPPS Table 5 (MS-DRG weights); PY2028 advance notice (February 2027) and the PY2027 midyear final mapping (spring 2027) for the ICD-10-CM to HCC mapping; weekly, every Thursday for the Medicare Coverage Database billing and coding articles.

Code
D57.1
billable FY2027 ICD-10-CM code
Category
D57 Sickle-cell disorders
Chapter
3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
CC/MCC (MS-DRG v44)
Neither
CMS-HCC V28
HCC 107
POA reporting
Required

Tabular list notes for D57.1

The tabular list has no notes on D57.1 itself; the notes below apply from its parent headings.

Inherited from D57 (Sickle-cell disorders)

Excludes1 (never coded together)
  • other hemoglobinopathies (D58.-)
Use additional code
  • code for any associated fever (R50.81)

MS-DRG grouping when D57.1 is the principal diagnosis

MS-DRG v44 groups for D57.1 as principal diagnosis
MDCMS-DRGs
16 MDC 16: Diseases and Disorders of Blood, Blood Forming Organs and Immunologic Disorders811812

The final group also depends on procedures, secondary diagnoses and discharge status; the MS-DRG lookup for D57.1 shows the full grouping logic.

CC/MCC status and inpatient edits

D57.1 is neither a CC nor an MCC under MS-DRG v44, so as a secondary diagnosis it does not raise the MS-DRG severity level. Check D57.1 against a principal diagnosis.

  • Present on admission: a POA indicator is required on inpatient claims.

CMS-HCC V28 risk adjustment

In the PY2027 mapping, D57.1 maps to HCC 107 (Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero). The HCC lookup shows the RAF weight and the hierarchy.

LCD billing and coding articles that list D57.1

21 current Medicare billing and coding articles list D57.1 among the diagnoses that support medical necessity for the services they cover.

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Frequently asked questions

What does ICD-10-CM D57.1 mean?

D57.1 means sickle-cell disease without crisis. It is one of 25 billable codes under D57, sickle-cell disorders.

What can't be coded with D57.1?

Excludes1 at D57: other hemoglobinopathies (D58.-). These are never reported together with D57.1.

Which MS-DRG does D57.1 group to?

As the principal diagnosis, D57.1 groups to MS-DRG 811 Red Blood Cell Disorders with MCC, MS-DRG 812 Red Blood Cell Disorders without MCC (MDC 16 MDC 16: Diseases and Disorders of Blood, Blood Forming Organs and Immunologic Disorders) under MS-DRG v44, before procedures and secondary diagnoses are applied.

Does D57.1 map to an HCC?

Yes: HCC 107, Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero, in the PY2027 CMS-HCC V28 mapping.

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-10. Verify against the primary file before billing or contracting decisions. The reference methodology explains how each figure is computed from these files.

Disclaimer

The descriptor and notes are reproduced from the FY2027 ICD-10-CM files; MS-DRG, CC/MCC and HCC facts come from the CMS FY2027 and PY2027 tables. Code from the medical record and the ICD-10-CM Official Guidelines. Not legal, clinical or billing advice.

Found a figure that does not match the CMS file? Report a data correction with the CMS file and the value you expected; the request reaches the editorial team through the contact form.