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HCC 21: Lymphoma and Other Cancers

HCC 21, Lymphoma and Other Cancers, is one of the 115 payment categories in the CMS-HCC V28 model. 463 ICD-10-CM codes map to it in the payment year 2027 mapping, and a documented diagnosis in the category adds a relative factor of 0.671 to the risk score of a community, non-dual, aged beneficiary (0.540 disabled, 0.493 institutional). It is overridden when a more severe category in its hierarchy is present (HCC 17, HCC 18, HCC 19, HCC 20) and it in turn overrides HCC 22, HCC 23.

QuickIntell editorial content · Legacy registry date · Review not verified

Data effective
Data currency: ICD-10-CM to HCC mapping PY2027 initial (effective dates of service 2026, payment year 2027); CMS-HCC V28 model software V2826.115.T2 (effective payment year 2027). Next CMS release: PY2027 midyear final mapping (spring 2027) and PY2028 proposed model (February 2027).
Mapped ICD-10-CM codes
463
Factor, community non-dual aged
0.671
Factor, institutional
0.493
Hierarchy
Overridden by HCC 17, HCC 18, HCC 19, HCC 20
Disease group
Neoplasm

Relative factors by segment

Each segment is a separate regression; the factor is added to the beneficiary's demographic factors and other categories, then normalized and reduced by the coding intensity adjustment before it meets the plan's base rate. A factor of 1.000 equals the expected cost of an average beneficiary.

CMS-HCC V28 relative factors for HCC 21 by model segment
SegmentModel codeRelative factor
Community, non-dual, agedCNA_HCC210.671
Community, non-dual, disabledCND_HCC210.540
Community, full-benefit dual, agedCFA_HCC210.654
Community, full-benefit dual, disabledCFD_HCC210.739
Community, partial-benefit dual, agedCPA_HCC210.627
Community, partial-benefit dual, disabledCPD_HCC210.618
Long-term institutionalINS_HCC210.493

Hierarchy

Hierarchical condition categories pay only the most severe manifestation of a disease. When HCC 17 (Cancer Metastatic to Lung, Liver, Brain, and Other Organs; Acute Myeloid Leukemia Except Promyelocytic) or HCC 18 (Cancer Metastatic to Bone, Other and Unspecified Metastatic Cancer; Acute Leukemia Except Myeloid) or HCC 19 (Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers) or HCC 20 (Lung and Other Severe Cancers) is also documented for the same beneficiary, HCC 21 is dropped from the score. When HCC 21 is present it drops HCC 22 (Bladder, Colorectal, and Other Cancers), HCC 23 (Prostate, Breast, and Other Cancers and Tumors), so documenting the less severe condition alongside it adds nothing to payment but still matters for the clinical record.

ICD-10-CM codes that map to HCC 21

463 codes map to this category in the PY2027 initial mapping, concentrated in the C82 (99), C81 (77), C85 (44), C83 (33), C4A (24), C7A (23) code families. Descriptions are the CMS mapping descriptions for the FY2026 code set; a code that is deleted or split in the October code update stays valid for dates of service before the change.

ICD-10-CM codes mapped to HCC 21 in the CMS PY2027 initial mapping
ICD-10-CMDescription
C01Malignant neoplasm of base of tongue
C020Malignant neoplasm of dorsal surface of tongue
C021Malignant neoplasm of border of tongue
C022Malignant neoplasm of ventral surface of tongue
C023Malignant neoplasm of anterior two-thirds of tongue, part unspecified
C024Malignant neoplasm of lingual tonsil
C028Malignant neoplasm of overlapping sites of tongue
C029Malignant neoplasm of tongue, unspecified
C030Malignant neoplasm of upper gum
C031Malignant neoplasm of lower gum
C039Malignant neoplasm of gum, unspecified
C040Malignant neoplasm of anterior floor of mouth
C041Malignant neoplasm of lateral floor of mouth
C048Malignant neoplasm of overlapping sites of floor of mouth
C049Malignant neoplasm of floor of mouth, unspecified
C050Malignant neoplasm of hard palate
C051Malignant neoplasm of soft palate
C052Malignant neoplasm of uvula
C058Malignant neoplasm of overlapping sites of palate
C059Malignant neoplasm of palate, unspecified
C060Malignant neoplasm of cheek mucosa
C061Malignant neoplasm of vestibule of mouth
C062Malignant neoplasm of retromolar area
C0680Malignant neoplasm of overlapping sites of unspecified parts of mouth
C0689Malignant neoplasm of overlapping sites of other parts of mouth
C069Malignant neoplasm of mouth, unspecified
C07Malignant neoplasm of parotid gland
C080Malignant neoplasm of submandibular gland
C081Malignant neoplasm of sublingual gland
C089Malignant neoplasm of major salivary gland, unspecified
C090Malignant neoplasm of tonsillar fossa
C091Malignant neoplasm of tonsillar pillar (anterior) (posterior)
C098Malignant neoplasm of overlapping sites of tonsil
C099Malignant neoplasm of tonsil, unspecified
C100Malignant neoplasm of vallecula
C101Malignant neoplasm of anterior surface of epiglottis
C102Malignant neoplasm of lateral wall of oropharynx
C103Malignant neoplasm of posterior wall of oropharynx
C104Malignant neoplasm of branchial cleft
C108Malignant neoplasm of overlapping sites of oropharynx
C109Malignant neoplasm of oropharynx, unspecified
C110Malignant neoplasm of superior wall of nasopharynx
C111Malignant neoplasm of posterior wall of nasopharynx
C112Malignant neoplasm of lateral wall of nasopharynx
C113Malignant neoplasm of anterior wall of nasopharynx
C118Malignant neoplasm of overlapping sites of nasopharynx
C119Malignant neoplasm of nasopharynx, unspecified
C12Malignant neoplasm of pyriform sinus
C130Malignant neoplasm of postcricoid region
C131Malignant neoplasm of aryepiglottic fold, hypopharyngeal aspect
C132Malignant neoplasm of posterior wall of hypopharynx
C138Malignant neoplasm of overlapping sites of hypopharynx
C139Malignant neoplasm of hypopharynx, unspecified
C140Malignant neoplasm of pharynx, unspecified
C142Malignant neoplasm of Waldeyer's ring
C148Malignant neoplasm of overlapping sites of lip, oral cavity and pharynx
C300Malignant neoplasm of nasal cavity
C301Malignant neoplasm of middle ear
C310Malignant neoplasm of maxillary sinus
C311Malignant neoplasm of ethmoidal sinus
C312Malignant neoplasm of frontal sinus
C313Malignant neoplasm of sphenoid sinus
C318Malignant neoplasm of overlapping sites of accessory sinuses
C319Malignant neoplasm of accessory sinus, unspecified
C320Malignant neoplasm of glottis
C321Malignant neoplasm of supraglottis
C322Malignant neoplasm of subglottis
C323Malignant neoplasm of laryngeal cartilage
C328Malignant neoplasm of overlapping sites of larynx
C329Malignant neoplasm of larynx, unspecified
C37Malignant neoplasm of thymus
C381Malignant neoplasm of anterior mediastinum
C382Malignant neoplasm of posterior mediastinum
C383Malignant neoplasm of mediastinum, part unspecified
C388Malignant neoplasm of overlapping sites of heart, mediastinum and pleura
C390Malignant neoplasm of upper respiratory tract, part unspecified
C399Malignant neoplasm of lower respiratory tract, part unspecified
C4000Malignant neoplasm of scapula and long bones of unspecified upper limb
C4001Malignant neoplasm of scapula and long bones of right upper limb
C4002Malignant neoplasm of scapula and long bones of left upper limb
C4010Malignant neoplasm of short bones of unspecified upper limb
C4011Malignant neoplasm of short bones of right upper limb
C4012Malignant neoplasm of short bones of left upper limb
C4020Malignant neoplasm of long bones of unspecified lower limb
C4021Malignant neoplasm of long bones of right lower limb
C4022Malignant neoplasm of long bones of left lower limb
C4030Malignant neoplasm of short bones of unspecified lower limb
C4031Malignant neoplasm of short bones of right lower limb
C4032Malignant neoplasm of short bones of left lower limb
C4080Malignant neoplasm of overlapping sites of bone and articular cartilage of unspecified limb
C4081Malignant neoplasm of overlapping sites of bone and articular cartilage of right limb
C4082Malignant neoplasm of overlapping sites of bone and articular cartilage of left limb
C4090Malignant neoplasm of unspecified bones and articular cartilage of unspecified limb
C4091Malignant neoplasm of unspecified bones and articular cartilage of right limb
C4092Malignant neoplasm of unspecified bones and articular cartilage of left limb
C410Malignant neoplasm of bones of skull and face
C411Malignant neoplasm of mandible
C412Malignant neoplasm of vertebral column
C413Malignant neoplasm of ribs, sternum and clavicle
C414Malignant neoplasm of pelvic bones, sacrum and coccyx
C419Malignant neoplasm of bone and articular cartilage, unspecified
C460Kaposi's sarcoma of skin
C461Kaposi's sarcoma of soft tissue
C462Kaposi's sarcoma of palate
C463Kaposi's sarcoma of lymph nodes
C464Kaposi's sarcoma of gastrointestinal sites
C4650Kaposi's sarcoma of unspecified lung
C4651Kaposi's sarcoma of right lung
C4652Kaposi's sarcoma of left lung
C467Kaposi's sarcoma of other sites
C469Kaposi's sarcoma, unspecified
C470Malignant neoplasm of peripheral nerves of head, face and neck
C4710Malignant neoplasm of peripheral nerves of unspecified upper limb, including shoulder
C4711Malignant neoplasm of peripheral nerves of right upper limb, including shoulder
C4712Malignant neoplasm of peripheral nerves of left upper limb, including shoulder
C4720Malignant neoplasm of peripheral nerves of unspecified lower limb, including hip
C4721Malignant neoplasm of peripheral nerves of right lower limb, including hip
C4722Malignant neoplasm of peripheral nerves of left lower limb, including hip
C473Malignant neoplasm of peripheral nerves of thorax
C475Malignant neoplasm of peripheral nerves of pelvis
C476Malignant neoplasm of peripheral nerves of trunk, unspecified
C478Malignant neoplasm of overlapping sites of peripheral nerves and autonomic nervous system
C479Malignant neoplasm of peripheral nerves and autonomic nervous system, unspecified
C490Malignant neoplasm of connective and soft tissue of head, face and neck
C4910Malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder
C4911Malignant neoplasm of connective and soft tissue of right upper limb, including shoulder
C4912Malignant neoplasm of connective and soft tissue of left upper limb, including shoulder
C4920Malignant neoplasm of connective and soft tissue of unspecified lower limb, including hip
C4921Malignant neoplasm of connective and soft tissue of right lower limb, including hip
C4922Malignant neoplasm of connective and soft tissue of left lower limb, including hip
C493Malignant neoplasm of connective and soft tissue of thorax
C495Malignant neoplasm of connective and soft tissue of pelvis
C496Malignant neoplasm of connective and soft tissue of trunk, unspecified
C498Malignant neoplasm of overlapping sites of connective and soft tissue
C499Malignant neoplasm of connective and soft tissue, unspecified
C4A0Merkel cell carcinoma of lip
C4A10Merkel cell carcinoma of unspecified eyelid, including canthus
C4A111Merkel cell carcinoma of right upper eyelid, including canthus
C4A112Merkel cell carcinoma of right lower eyelid, including canthus
C4A121Merkel cell carcinoma of left upper eyelid, including canthus
C4A122Merkel cell carcinoma of left lower eyelid, including canthus
C4A20Merkel cell carcinoma of unspecified ear and external auricular canal
C4A21Merkel cell carcinoma of right ear and external auricular canal
C4A22Merkel cell carcinoma of left ear and external auricular canal
C4A30Merkel cell carcinoma of unspecified part of face
C4A31Merkel cell carcinoma of nose
C4A39Merkel cell carcinoma of other parts of face
C4A4Merkel cell carcinoma of scalp and neck
C4A51Merkel cell carcinoma of anal skin
C4A52Merkel cell carcinoma of skin of breast
C4A59Merkel cell carcinoma of other part of trunk
C4A60Merkel cell carcinoma of unspecified upper limb, including shoulder
C4A61Merkel cell carcinoma of right upper limb, including shoulder
C4A62Merkel cell carcinoma of left upper limb, including shoulder
C4A70Merkel cell carcinoma of unspecified lower limb, including hip
C4A71Merkel cell carcinoma of right lower limb, including hip
C4A72Merkel cell carcinoma of left lower limb, including hip
C4A8Merkel cell carcinoma of overlapping sites
C4A9Merkel cell carcinoma, unspecified
C7A00Malignant carcinoid tumor of unspecified site
C7A010Malignant carcinoid tumor of the duodenum
C7A011Malignant carcinoid tumor of the jejunum
C7A012Malignant carcinoid tumor of the ileum
C7A019Malignant carcinoid tumor of the small intestine, unspecified portion
C7A020Malignant carcinoid tumor of the appendix
C7A021Malignant carcinoid tumor of the cecum
C7A022Malignant carcinoid tumor of the ascending colon
C7A023Malignant carcinoid tumor of the transverse colon
C7A024Malignant carcinoid tumor of the descending colon
C7A025Malignant carcinoid tumor of the sigmoid colon
C7A026Malignant carcinoid tumor of the rectum
C7A029Malignant carcinoid tumor of the large intestine, unspecified portion
C7A090Malignant carcinoid tumor of the bronchus and lung
C7A091Malignant carcinoid tumor of the thymus
C7A092Malignant carcinoid tumor of the stomach
C7A093Malignant carcinoid tumor of the kidney
C7A094Malignant carcinoid tumor of the foregut, unspecified
C7A095Malignant carcinoid tumor of the midgut, unspecified
C7A096Malignant carcinoid tumor of the hindgut, unspecified
C7A098Malignant carcinoid tumors of other sites
C7A1Malignant poorly differentiated neuroendocrine tumors
C7A8Other malignant neuroendocrine tumors
C8100Nodular lymphocyte predominant Hodgkin lymphoma, unspecified site
C8101Nodular lymphocyte predominant Hodgkin lymphoma, lymph nodes of head, face, and neck
C8102Nodular lymphocyte predominant Hodgkin lymphoma, intrathoracic lymph nodes
C8103Nodular lymphocyte predominant Hodgkin lymphoma, intra-abdominal lymph nodes
C8104Nodular lymphocyte predominant Hodgkin lymphoma, lymph nodes of axilla and upper limb
C8105Nodular lymphocyte predominant Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
C8106Nodular lymphocyte predominant Hodgkin lymphoma, intrapelvic lymph nodes
C8107Nodular lymphocyte predominant Hodgkin lymphoma, spleen
C8108Nodular lymphocyte predominant Hodgkin lymphoma, lymph nodes of multiple sites
C8109Nodular lymphocyte predominant Hodgkin lymphoma, extranodal and solid organ sites
C810ANodular lymphocyte predominant Hodgkin lymphoma, in remission
C8110Nodular sclerosis Hodgkin lymphoma, unspecified site
C8111Nodular sclerosis Hodgkin lymphoma, lymph nodes of head, face, and neck
C8112Nodular sclerosis Hodgkin lymphoma, intrathoracic lymph nodes
C8113Nodular sclerosis Hodgkin lymphoma, intra-abdominal lymph nodes
C8114Nodular sclerosis Hodgkin lymphoma, lymph nodes of axilla and upper limb
C8115Nodular sclerosis Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
C8116Nodular sclerosis Hodgkin lymphoma, intrapelvic lymph nodes
C8117Nodular sclerosis Hodgkin lymphoma, spleen
C8118Nodular sclerosis Hodgkin lymphoma, lymph nodes of multiple sites
C8119Nodular sclerosis Hodgkin lymphoma, extranodal and solid organ sites
C811ANodular sclerosis Hodgkin lymphoma, in remission
C8120Mixed cellularity Hodgkin lymphoma, unspecified site
C8121Mixed cellularity Hodgkin lymphoma, lymph nodes of head, face, and neck
C8122Mixed cellularity Hodgkin lymphoma, intrathoracic lymph nodes
C8123Mixed cellularity Hodgkin lymphoma, intra-abdominal lymph nodes
C8124Mixed cellularity Hodgkin lymphoma, lymph nodes of axilla and upper limb
C8125Mixed cellularity Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
C8126Mixed cellularity Hodgkin lymphoma, intrapelvic lymph nodes
C8127Mixed cellularity Hodgkin lymphoma, spleen
C8128Mixed cellularity Hodgkin lymphoma, lymph nodes of multiple sites
C8129Mixed cellularity Hodgkin lymphoma, extranodal and solid organ sites
C812AMixed cellularity Hodgkin lymphoma, in remission
C8130Lymphocyte depleted Hodgkin lymphoma, unspecified site
C8131Lymphocyte depleted Hodgkin lymphoma, lymph nodes of head, face, and neck
C8132Lymphocyte depleted Hodgkin lymphoma, intrathoracic lymph nodes
C8133Lymphocyte depleted Hodgkin lymphoma, intra-abdominal lymph nodes
C8134Lymphocyte depleted Hodgkin lymphoma, lymph nodes of axilla and upper limb
C8135Lymphocyte depleted Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
C8136Lymphocyte depleted Hodgkin lymphoma, intrapelvic lymph nodes
C8137Lymphocyte depleted Hodgkin lymphoma, spleen
C8138Lymphocyte depleted Hodgkin lymphoma, lymph nodes of multiple sites
C8139Lymphocyte depleted Hodgkin lymphoma, extranodal and solid organ sites
C813ALymphocyte depleted Hodgkin lymphoma, in remission
C8140Lymphocyte-rich Hodgkin lymphoma, unspecified site
C8141Lymphocyte-rich Hodgkin lymphoma, lymph nodes of head, face, and neck
C8142Lymphocyte-rich Hodgkin lymphoma, intrathoracic lymph nodes
C8143Lymphocyte-rich Hodgkin lymphoma, intra-abdominal lymph nodes
C8144Lymphocyte-rich Hodgkin lymphoma, lymph nodes of axilla and upper limb
C8145Lymphocyte-rich Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
C8146Lymphocyte-rich Hodgkin lymphoma, intrapelvic lymph nodes
C8147Lymphocyte-rich Hodgkin lymphoma, spleen
C8148Lymphocyte-rich Hodgkin lymphoma, lymph nodes of multiple sites
C8149Lymphocyte-rich Hodgkin lymphoma, extranodal and solid organ sites
C814ALymphocyte-rich Hodgkin lymphoma, in remission
C8170Other Hodgkin lymphoma, unspecified site
C8171Other Hodgkin lymphoma, lymph nodes of head, face, and neck
C8172Other Hodgkin lymphoma, intrathoracic lymph nodes
C8173Other Hodgkin lymphoma, intra-abdominal lymph nodes
C8174Other Hodgkin lymphoma, lymph nodes of axilla and upper limb
C8175Other Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
C8176Other Hodgkin lymphoma, intrapelvic lymph nodes
C8177Other Hodgkin lymphoma, spleen
C8178Other Hodgkin lymphoma, lymph nodes of multiple sites
C8179Other Hodgkin lymphoma, extranodal and solid organ sites
C817AOther Hodgkin lymphoma, in remission
C8190Hodgkin lymphoma, unspecified, unspecified site
C8191Hodgkin lymphoma, unspecified, lymph nodes of head, face, and neck
C8192Hodgkin lymphoma, unspecified, intrathoracic lymph nodes
C8193Hodgkin lymphoma, unspecified, intra-abdominal lymph nodes
C8194Hodgkin lymphoma, unspecified, lymph nodes of axilla and upper limb
C8195Hodgkin lymphoma, unspecified, lymph nodes of inguinal region and lower limb
C8196Hodgkin lymphoma, unspecified, intrapelvic lymph nodes
C8197Hodgkin lymphoma, unspecified, spleen
C8198Hodgkin lymphoma, unspecified, lymph nodes of multiple sites
C8199Hodgkin lymphoma, unspecified, extranodal and solid organ sites
C819AHodgkin lymphoma, unspecified, in remission
C8200Follicular lymphoma grade I, unspecified site
C8201Follicular lymphoma grade I, lymph nodes of head, face, and neck
C8202Follicular lymphoma grade I, intrathoracic lymph nodes
C8203Follicular lymphoma grade I, intra-abdominal lymph nodes
C8204Follicular lymphoma grade I, lymph nodes of axilla and upper limb
C8205Follicular lymphoma grade I, lymph nodes of inguinal region and lower limb
C8206Follicular lymphoma grade I, intrapelvic lymph nodes
C8207Follicular lymphoma grade I, spleen
C8208Follicular lymphoma grade I, lymph nodes of multiple sites
C8209Follicular lymphoma grade I, extranodal and solid organ sites
C820AFollicular lymphoma grade I, in remission
C8210Follicular lymphoma grade II, unspecified site
C8211Follicular lymphoma grade II, lymph nodes of head, face, and neck
C8212Follicular lymphoma grade II, intrathoracic lymph nodes
C8213Follicular lymphoma grade II, intra-abdominal lymph nodes
C8214Follicular lymphoma grade II, lymph nodes of axilla and upper limb
C8215Follicular lymphoma grade II, lymph nodes of inguinal region and lower limb
C8216Follicular lymphoma grade II, intrapelvic lymph nodes
C8217Follicular lymphoma grade II, spleen
C8218Follicular lymphoma grade II, lymph nodes of multiple sites
C8219Follicular lymphoma grade II, extranodal and solid organ sites
C821AFollicular lymphoma grade II, in remission
C8220Follicular lymphoma grade III, unspecified, unspecified site
C8221Follicular lymphoma grade III, unspecified, lymph nodes of head, face, and neck
C8222Follicular lymphoma grade III, unspecified, intrathoracic lymph nodes
C8223Follicular lymphoma grade III, unspecified, intra-abdominal lymph nodes
C8224Follicular lymphoma grade III, unspecified, lymph nodes of axilla and upper limb
C8225Follicular lymphoma grade III, unspecified, lymph nodes of inguinal region and lower limb
C8226Follicular lymphoma grade III, unspecified, intrapelvic lymph nodes
C8227Follicular lymphoma grade III, unspecified, spleen
C8228Follicular lymphoma grade III, unspecified, lymph nodes of multiple sites
C8229Follicular lymphoma grade III, unspecified, extranodal and solid organ sites
C822AFollicular lymphoma grade III, unspecified, in remission
C8230Follicular lymphoma grade IIIa, unspecified site
C8231Follicular lymphoma grade IIIa, lymph nodes of head, face, and neck
C8232Follicular lymphoma grade IIIa, intrathoracic lymph nodes
C8233Follicular lymphoma grade IIIa, intra-abdominal lymph nodes
C8234Follicular lymphoma grade IIIa, lymph nodes of axilla and upper limb
C8235Follicular lymphoma grade IIIa, lymph nodes of inguinal region and lower limb
C8236Follicular lymphoma grade IIIa, intrapelvic lymph nodes
C8237Follicular lymphoma grade IIIa, spleen
C8238Follicular lymphoma grade IIIa, lymph nodes of multiple sites
C8239Follicular lymphoma grade IIIa, extranodal and solid organ sites
C823AFollicular lymphoma grade IIIa, in remission
C8240Follicular lymphoma grade IIIb, unspecified site
C8241Follicular lymphoma grade IIIb, lymph nodes of head, face, and neck
C8242Follicular lymphoma grade IIIb, intrathoracic lymph nodes
C8243Follicular lymphoma grade IIIb, intra-abdominal lymph nodes
C8244Follicular lymphoma grade IIIb, lymph nodes of axilla and upper limb
C8245Follicular lymphoma grade IIIb, lymph nodes of inguinal region and lower limb
C8246Follicular lymphoma grade IIIb, intrapelvic lymph nodes
C8247Follicular lymphoma grade IIIb, spleen
C8248Follicular lymphoma grade IIIb, lymph nodes of multiple sites
C8249Follicular lymphoma grade IIIb, extranodal and solid organ sites
C824AFollicular lymphoma grade IIIb, in remission
C8250Diffuse follicle center lymphoma, unspecified site
C8251Diffuse follicle center lymphoma, lymph nodes of head, face, and neck
C8252Diffuse follicle center lymphoma, intrathoracic lymph nodes
C8253Diffuse follicle center lymphoma, intra-abdominal lymph nodes
C8254Diffuse follicle center lymphoma, lymph nodes of axilla and upper limb
C8255Diffuse follicle center lymphoma, lymph nodes of inguinal region and lower limb
C8256Diffuse follicle center lymphoma, intrapelvic lymph nodes
C8257Diffuse follicle center lymphoma, spleen
C8258Diffuse follicle center lymphoma, lymph nodes of multiple sites
C8259Diffuse follicle center lymphoma, extranodal and solid organ sites
C825ADiffuse follicle center lymphoma, in remission
C8260Cutaneous follicle center lymphoma, unspecified site
C8261Cutaneous follicle center lymphoma, lymph nodes of head, face, and neck
C8262Cutaneous follicle center lymphoma, intrathoracic lymph nodes
C8263Cutaneous follicle center lymphoma, intra-abdominal lymph nodes
C8264Cutaneous follicle center lymphoma, lymph nodes of axilla and upper limb
C8265Cutaneous follicle center lymphoma, lymph nodes of inguinal region and lower limb
C8266Cutaneous follicle center lymphoma, intrapelvic lymph nodes
C8267Cutaneous follicle center lymphoma, spleen
C8268Cutaneous follicle center lymphoma, lymph nodes of multiple sites
C8269Cutaneous follicle center lymphoma, extranodal and solid organ sites
C826ACutaneous follicle center lymphoma, in remission
C8280Other types of follicular lymphoma, unspecified site
C8281Other types of follicular lymphoma, lymph nodes of head, face, and neck
C8282Other types of follicular lymphoma, intrathoracic lymph nodes
C8283Other types of follicular lymphoma, intra-abdominal lymph nodes
C8284Other types of follicular lymphoma, lymph nodes of axilla and upper limb
C8285Other types of follicular lymphoma, lymph nodes of inguinal region and lower limb
C8286Other types of follicular lymphoma, intrapelvic lymph nodes
C8287Other types of follicular lymphoma, spleen
C8288Other types of follicular lymphoma, lymph nodes of multiple sites
C8289Other types of follicular lymphoma, extranodal and solid organ sites
C828AOther types of follicular lymphoma, in remission
C8290Follicular lymphoma, unspecified, unspecified site
C8291Follicular lymphoma, unspecified, lymph nodes of head, face, and neck
C8292Follicular lymphoma, unspecified, intrathoracic lymph nodes
C8293Follicular lymphoma, unspecified, intra-abdominal lymph nodes
C8294Follicular lymphoma, unspecified, lymph nodes of axilla and upper limb
C8295Follicular lymphoma, unspecified, lymph nodes of inguinal region and lower limb
C8296Follicular lymphoma, unspecified, intrapelvic lymph nodes
C8297Follicular lymphoma, unspecified, spleen
C8298Follicular lymphoma, unspecified, lymph nodes of multiple sites
C8299Follicular lymphoma, unspecified, extranodal and solid organ sites
C829AFollicular lymphoma, unspecified, in remission
C8300Small cell B-cell lymphoma, unspecified site
C8301Small cell B-cell lymphoma, lymph nodes of head, face, and neck
C8302Small cell B-cell lymphoma, intrathoracic lymph nodes
C8303Small cell B-cell lymphoma, intra-abdominal lymph nodes
C8304Small cell B-cell lymphoma, lymph nodes of axilla and upper limb
C8305Small cell B-cell lymphoma, lymph nodes of inguinal region and lower limb
C8306Small cell B-cell lymphoma, intrapelvic lymph nodes
C8307Small cell B-cell lymphoma, spleen
C8308Small cell B-cell lymphoma, lymph nodes of multiple sites
C8309Small cell B-cell lymphoma, extranodal and solid organ sites
C830ASmall cell B-cell lymphoma, in remission
C8380Other non-follicular lymphoma, unspecified site
C8381Other non-follicular lymphoma, lymph nodes of head, face, and neck
C8382Other non-follicular lymphoma, intrathoracic lymph nodes
C8383Other non-follicular lymphoma, intra-abdominal lymph nodes
C8384Other non-follicular lymphoma, lymph nodes of axilla and upper limb
C8385Other non-follicular lymphoma, lymph nodes of inguinal region and lower limb
C8386Other non-follicular lymphoma, intrapelvic lymph nodes
C8387Other non-follicular lymphoma, spleen
C8388Other non-follicular lymphoma, lymph nodes of multiple sites
C8389Other non-follicular lymphoma, extranodal and solid organ sites
C838AOther non-follicular lymphoma, in remission
C8390Non-follicular (diffuse) lymphoma, unspecified, unspecified site
C8391Non-follicular (diffuse) lymphoma, unspecified, lymph nodes of head, face, and neck
C8392Non-follicular (diffuse) lymphoma, unspecified, intrathoracic lymph nodes
C8393Non-follicular (diffuse) lymphoma, unspecified, intra-abdominal lymph nodes
C8394Non-follicular (diffuse) lymphoma, unspecified, lymph nodes of axilla and upper limb
C8395Non-follicular (diffuse) lymphoma, unspecified, lymph nodes of inguinal region and lower limb
C8396Non-follicular (diffuse) lymphoma, unspecified, intrapelvic lymph nodes
C8397Non-follicular (diffuse) lymphoma, unspecified, spleen
C8398Non-follicular (diffuse) lymphoma, unspecified, lymph nodes of multiple sites
C8399Non-follicular (diffuse) lymphoma, unspecified, extranodal and solid organ sites
C839ANon-follicular (diffuse) lymphoma, unspecified, in remission
C8510Unspecified B-cell lymphoma, unspecified site
C8511Unspecified B-cell lymphoma, lymph nodes of head, face, and neck
C8512Unspecified B-cell lymphoma, intrathoracic lymph nodes
C8513Unspecified B-cell lymphoma, intra-abdominal lymph nodes
C8514Unspecified B-cell lymphoma, lymph nodes of axilla and upper limb
C8515Unspecified B-cell lymphoma, lymph nodes of inguinal region and lower limb
C8516Unspecified B-cell lymphoma, intrapelvic lymph nodes
C8517Unspecified B-cell lymphoma, spleen
C8518Unspecified B-cell lymphoma, lymph nodes of multiple sites
C8519Unspecified B-cell lymphoma, extranodal and solid organ sites
C851AUnspecified B-cell lymphoma, in remission
C8520Mediastinal (thymic) large B-cell lymphoma, unspecified site
C8521Mediastinal (thymic) large B-cell lymphoma, lymph nodes of head, face, and neck
C8522Mediastinal (thymic) large B-cell lymphoma, intrathoracic lymph nodes
C8523Mediastinal (thymic) large B-cell lymphoma, intra-abdominal lymph nodes
C8524Mediastinal (thymic) large B-cell lymphoma, lymph nodes of axilla and upper limb
C8525Mediastinal (thymic) large B-cell lymphoma, lymph nodes of inguinal region and lower limb
C8526Mediastinal (thymic) large B-cell lymphoma, intrapelvic lymph nodes
C8527Mediastinal (thymic) large B-cell lymphoma, spleen
C8528Mediastinal (thymic) large B-cell lymphoma, lymph nodes of multiple sites
C8529Mediastinal (thymic) large B-cell lymphoma, extranodal and solid organ sites
C852AMediastinal (thymic) large B-cell lymphoma, in remission
C8580Other specified types of non-Hodgkin lymphoma, unspecified site
C8581Other specified types of non-Hodgkin lymphoma, lymph nodes of head, face, and neck
C8582Other specified types of non-Hodgkin lymphoma, intrathoracic lymph nodes
C8583Other specified types of non-Hodgkin lymphoma, intra-abdominal lymph nodes
C8584Other specified types of non-Hodgkin lymphoma, lymph nodes of axilla and upper limb
C8585Other specified types of non-Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
C8586Other specified types of non-Hodgkin lymphoma, intrapelvic lymph nodes
C8587Other specified types of non-Hodgkin lymphoma, spleen
C8588Other specified types of non-Hodgkin lymphoma, lymph nodes of multiple sites
C8589Other specified types of non-Hodgkin lymphoma, extranodal and solid organ sites
C858AOther specified types of non-Hodgkin lymphoma, in remission
C8590Non-Hodgkin lymphoma, unspecified, unspecified site
C8591Non-Hodgkin lymphoma, unspecified, lymph nodes of head, face, and neck
C8592Non-Hodgkin lymphoma, unspecified, intrathoracic lymph nodes
C8593Non-Hodgkin lymphoma, unspecified, intra-abdominal lymph nodes
C8594Non-Hodgkin lymphoma, unspecified, lymph nodes of axilla and upper limb
C8595Non-Hodgkin lymphoma, unspecified, lymph nodes of inguinal region and lower limb
C8596Non-Hodgkin lymphoma, unspecified, intrapelvic lymph nodes
C8597Non-Hodgkin lymphoma, unspecified, spleen
C8598Non-Hodgkin lymphoma, unspecified, lymph nodes of multiple sites
C8599Non-Hodgkin lymphoma, unspecified, extranodal and solid organ sites
C859ANon-Hodgkin lymphoma, unspecified, in remission
C8800Waldenstrom macroglobulinemia not having achieved remission
C8801Waldenstrom macroglobulinemia, in remission
C8820Heavy chain disease not having achieved remission
C8821Heavy chain disease, in remission
C8830Immunoproliferative small intestinal disease not having achieved remission
C8831Immunoproliferative small intestinal disease, in remission
C8840Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma] not having achieved remission
C8841Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma], in remission
C8880Other malignant immunoproliferative diseases not having achieved remission
C8881Other malignant immunoproliferative diseases, in remission
C8890Malignant immunoproliferative disease, unspecified not having achieved remission
C8891Malignant immunoproliferative disease, unspecified, in remission
C960Multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis
C9620Malignant mast cell neoplasm, unspecified
C9621Aggressive systemic mastocytosis
C9622Mast cell sarcoma
C9629Other malignant mast cell neoplasm
C964Sarcoma of dendritic cells (accessory cells)
C965Multifocal and unisystemic Langerhans-cell histiocytosis
C966Unifocal Langerhans-cell histiocytosis
C969Malignant neoplasm of lymphoid, hematopoietic and related tissue, unspecified
C96AHistiocytic sarcoma
C96ZOther specified malignant neoplasms of lymphoid, hematopoietic and related tissue
D471Chronic myeloproliferative disease
D479Neoplasm of uncertain behavior of lymphoid, hematopoietic and related tissue, unspecified
D47Z1Post-transplant lymphoproliferative disorder (PTLD)
D47Z2Castleman disease
D47Z9Other specified neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue

Where these codes sat in the V22 model

The V28 recalibration renumbered and regrouped categories; this table shows which legacy V22 categories the same ICD-10 codes belonged to, which is the quickest way to reconcile a V22-era HCC gap list with the current model.

V22 categories that the HCC 21 codes mapped to
V22 HCCCodes
10332
1177
1247
485
232

Capturing and defending the category

A category counts for a payment year when a mapped diagnosis is documented at least once during the data collection year by an acceptable provider type at a face-to-face or audio-video encounter, and when the note shows the condition was monitored, evaluated, assessed or treated. Chronic conditions do not carry forward: a category that is not re-documented in the year drops out of the score, which is why annual wellness visits and problem-list reconciliation are where most recapture happens. Risk adjustment data validation audits sample enrollees and ask for the medical record behind each submitted category; an unsupported category is removed and, under the extrapolation rules, the error rate is applied across the contract. The QuickIntell risk adjustment product surfaces suspected and unsupported categories from the chart, and the HCC hub lists every V28 category with its factor and code count.

Frequently asked questions

Which ICD-10 codes map to HCC 21?

463 ICD-10-CM codes map to HCC 21 in the CMS PY2027 initial mapping, for example C01 Malignant neoplasm of base of tongue; C020 Malignant neoplasm of dorsal surface of tongue; C021 Malignant neoplasm of border of tongue; C022 Malignant neoplasm of ventral surface of tongue. The full list is on this page; a code counts only when it is documented at a face-to-face or video encounter in the data collection year and supported by the record.

How much does HCC 21 add to a risk score?

The V28 relative factor for HCC 21 is 0.671 for a community, non-dual, aged beneficiary, 0.654 for full-benefit dual aged, 0.540 for non-dual disabled and 0.493 for long-term institutional members. A factor of 1.000 equals the expected annual cost of an average beneficiary, so the category's share of the payment follows the plan's base rate for that segment.

Does HCC 21 count together with related categories?

No. Within a hierarchy only the most severe category is paid. HCC 21 is dropped when HCC 17 (Cancer Metastatic to Lung, Liver, Brain, and Other Organs; Acute Myeloid Leukemia Except Promyelocytic) or HCC 18 (Cancer Metastatic to Bone, Other and Unspecified Metastatic Cancer; Acute Leukemia Except Myeloid) or HCC 19 (Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers) or HCC 20 (Lung and Other Severe Cancers) is also present, and it drops HCC 22, HCC 23 when it is present.

What has to be documented for HCC 21 to be valid?

The diagnosis must be recorded by an acceptable provider type during a face-to-face or audio-video encounter in the service year, with the note showing that the condition was monitored, evaluated, assessed or treated. Risk adjustment data validation audits recover payment for categories the record does not support, so the code on the claim and the assessment in the note must match.

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-02. Verify against the primary file before billing or contracting decisions.

Disclaimer

Relative factors and mappings are reproduced from the CMS risk adjustment model files as an operational reference. Payment depends on the plan's base rate, normalization, the coding intensity adjustment and the enrollee's segment. Not legal, clinical or billing advice.