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HCC 19: Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers

HCC 19, Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers, is one of the 115 payment categories in the CMS-HCC V28 model. 68 ICD-10-CM codes map to it in the payment year 2027 mapping, and a documented diagnosis in the category adds a relative factor of 1.798 to the risk score of a community, non-dual, aged beneficiary (1.989 disabled, 0.957 institutional). It is overridden when a more severe category in its hierarchy is present (HCC 17, HCC 18) and it in turn overrides HCC 20, HCC 21, HCC 22, HCC 23.

QuickIntell editorial content · Legacy registry date · Review not verified

Data effective
Data currency: ICD-10-CM to HCC mapping PY2027 initial (effective dates of service 2026, payment year 2027); CMS-HCC V28 model software V2826.115.T2 (effective payment year 2027). Next CMS release: PY2027 midyear final mapping (spring 2027) and PY2028 proposed model (February 2027).
Mapped ICD-10-CM codes
68
Factor, community non-dual aged
1.798
Factor, institutional
0.957
Hierarchy
Overridden by HCC 17, HCC 18
Disease group
Neoplasm

Relative factors by segment

Each segment is a separate regression; the factor is added to the beneficiary's demographic factors and other categories, then normalized and reduced by the coding intensity adjustment before it meets the plan's base rate. A factor of 1.000 equals the expected cost of an average beneficiary.

CMS-HCC V28 relative factors for HCC 19 by model segment
SegmentModel codeRelative factor
Community, non-dual, agedCNA_HCC191.798
Community, non-dual, disabledCND_HCC191.989
Community, full-benefit dual, agedCFA_HCC191.563
Community, full-benefit dual, disabledCFD_HCC191.661
Community, partial-benefit dual, agedCPA_HCC191.520
Community, partial-benefit dual, disabledCPD_HCC191.554
Long-term institutionalINS_HCC190.957

Hierarchy

Hierarchical condition categories pay only the most severe manifestation of a disease. When HCC 17 (Cancer Metastatic to Lung, Liver, Brain, and Other Organs; Acute Myeloid Leukemia Except Promyelocytic) or HCC 18 (Cancer Metastatic to Bone, Other and Unspecified Metastatic Cancer; Acute Leukemia Except Myeloid) is also documented for the same beneficiary, HCC 19 is dropped from the score. When HCC 19 is present it drops HCC 20 (Lung and Other Severe Cancers), HCC 21 (Lymphoma and Other Cancers), HCC 22 (Bladder, Colorectal, and Other Cancers), HCC 23 (Prostate, Breast, and Other Cancers and Tumors), so documenting the less severe condition alongside it adds nothing to payment but still matters for the clinical record.

ICD-10-CM codes that map to HCC 19

68 codes map to this category in the PY2027 initial mapping, concentrated in the C84 (23), C90 (12), D46 (10), C91 (9), C86 (6), C45 (5) code families. Descriptions are the CMS mapping descriptions for the FY2026 code set; a code that is deleted or split in the October code update stays valid for dates of service before the change.

ICD-10-CM codes mapped to HCC 19 in the CMS PY2027 initial mapping
ICD-10-CMDescription
C450Mesothelioma of pleura
C451Mesothelioma of peritoneum
C452Mesothelioma of pericardium
C457Mesothelioma of other sites
C459Mesothelioma, unspecified
C8440Peripheral T-cell lymphoma, not elsewhere classified, unspecified site
C8441Peripheral T-cell lymphoma, not elsewhere classified, lymph nodes of head, face, and neck
C8442Peripheral T-cell lymphoma, not elsewhere classified, intrathoracic lymph nodes
C8443Peripheral T-cell lymphoma, not elsewhere classified, intra-abdominal lymph nodes
C8444Peripheral T-cell lymphoma, not elsewhere classified, lymph nodes of axilla and upper limb
C8445Peripheral T-cell lymphoma, not elsewhere classified, lymph nodes of inguinal region and lower limb
C8446Peripheral T-cell lymphoma, not elsewhere classified, intrapelvic lymph nodes
C8447Peripheral T-cell lymphoma, not elsewhere classified, spleen
C8448Peripheral T-cell lymphoma, not elsewhere classified, lymph nodes of multiple sites
C8449Peripheral T-cell lymphoma, not elsewhere classified, extranodal and solid organ sites
C844APeripheral T-cell lymphoma, not elsewhere classified, in remission
C8470Anaplastic large cell lymphoma, ALK-negative, unspecified site
C8471Anaplastic large cell lymphoma, ALK-negative, lymph nodes of head, face, and neck
C8472Anaplastic large cell lymphoma, ALK-negative, intrathoracic lymph nodes
C8473Anaplastic large cell lymphoma, ALK-negative, intra-abdominal lymph nodes
C8474Anaplastic large cell lymphoma, ALK-negative, lymph nodes of axilla and upper limb
C8475Anaplastic large cell lymphoma, ALK-negative, lymph nodes of inguinal region and lower limb
C8476Anaplastic large cell lymphoma, ALK-negative, intrapelvic lymph nodes
C8477Anaplastic large cell lymphoma, ALK-negative, spleen
C8478Anaplastic large cell lymphoma, ALK-negative, lymph nodes of multiple sites
C8479Anaplastic large cell lymphoma, ALK-negative, extranodal and solid organ sites
C847AAnaplastic large cell lymphoma, ALK-negative, breast
C847BAnaplastic large cell lymphoma, ALK-negative, in remission
C8630Subcutaneous panniculitis-like T-cell lymphoma not having achieved remission
C8631Subcutaneous panniculitis-like T-cell lymphoma, in remission
C8640Blastic NK-cell lymphoma not having achieved remission
C8641Blastic NK-cell lymphoma, in remission
C8650Angioimmunoblastic T-cell lymphoma not having achieved remission
C8651Angioimmunoblastic T-cell lymphoma, in remission
C9000Multiple myeloma not having achieved remission
C9001Multiple myeloma in remission
C9002Multiple myeloma in relapse
C9010Plasma cell leukemia not having achieved remission
C9011Plasma cell leukemia in remission
C9012Plasma cell leukemia in relapse
C9020Extramedullary plasmacytoma not having achieved remission
C9021Extramedullary plasmacytoma in remission
C9022Extramedullary plasmacytoma in relapse
C9030Solitary plasmacytoma not having achieved remission
C9031Solitary plasmacytoma in remission
C9032Solitary plasmacytoma in relapse
C9130Prolymphocytic leukemia of B-cell type not having achieved remission
C9131Prolymphocytic leukemia of B-cell type, in remission
C9132Prolymphocytic leukemia of B-cell type, in relapse
C9150Adult T-cell lymphoma/leukemia (HTLV-1-associated) not having achieved remission
C9151Adult T-cell lymphoma/leukemia (HTLV-1-associated), in remission
C9152Adult T-cell lymphoma/leukemia (HTLV-1-associated), in relapse
C9160Prolymphocytic leukemia of T-cell type not having achieved remission
C9161Prolymphocytic leukemia of T-cell type, in remission
C9162Prolymphocytic leukemia of T-cell type, in relapse
C946Myelodysplastic disease, not elsewhere classified
D460Refractory anemia without ring sideroblasts, so stated
D461Refractory anemia with ring sideroblasts
D4620Refractory anemia with excess of blasts, unspecified
D4621Refractory anemia with excess of blasts 1
D464Refractory anemia, unspecified
D469Myelodysplastic syndrome, unspecified
D46ARefractory cytopenia with multilineage dysplasia
D46BRefractory cytopenia with multilineage dysplasia and ring sideroblasts
D46CMyelodysplastic syndrome with isolated del(5q) chromosomal abnormality
D46ZOther myelodysplastic syndromes
D474Osteomyelofibrosis
D7581Myelofibrosis

Where these codes sat in the V22 model

The V28 recalibration renumbered and regrouped categories; this table shows which legacy V22 categories the same ICD-10 codes belonged to, which is the quickest way to reconcile a V22-era HCC gap list with the current model.

V22 categories that the HCC 19 codes mapped to
V22 HCCCodes
1041
914
4612
481

Capturing and defending the category

A category counts for a payment year when a mapped diagnosis is documented at least once during the data collection year by an acceptable provider type at a face-to-face or audio-video encounter, and when the note shows the condition was monitored, evaluated, assessed or treated. Chronic conditions do not carry forward: a category that is not re-documented in the year drops out of the score, which is why annual wellness visits and problem-list reconciliation are where most recapture happens. Risk adjustment data validation audits sample enrollees and ask for the medical record behind each submitted category; an unsupported category is removed and, under the extrapolation rules, the error rate is applied across the contract. The QuickIntell risk adjustment product surfaces suspected and unsupported categories from the chart, and the HCC hub lists every V28 category with its factor and code count.

Frequently asked questions

Which ICD-10 codes map to HCC 19?

68 ICD-10-CM codes map to HCC 19 in the CMS PY2027 initial mapping, for example C450 Mesothelioma of pleura; C451 Mesothelioma of peritoneum; C452 Mesothelioma of pericardium; C457 Mesothelioma of other sites. The full list is on this page; a code counts only when it is documented at a face-to-face or video encounter in the data collection year and supported by the record.

How much does HCC 19 add to a risk score?

The V28 relative factor for HCC 19 is 1.798 for a community, non-dual, aged beneficiary, 1.563 for full-benefit dual aged, 1.989 for non-dual disabled and 0.957 for long-term institutional members. A factor of 1.000 equals the expected annual cost of an average beneficiary, so the category's share of the payment follows the plan's base rate for that segment.

Does HCC 19 count together with related categories?

No. Within a hierarchy only the most severe category is paid. HCC 19 is dropped when HCC 17 (Cancer Metastatic to Lung, Liver, Brain, and Other Organs; Acute Myeloid Leukemia Except Promyelocytic) or HCC 18 (Cancer Metastatic to Bone, Other and Unspecified Metastatic Cancer; Acute Leukemia Except Myeloid) is also present, and it drops HCC 20, HCC 21, HCC 22, HCC 23 when it is present.

What has to be documented for HCC 19 to be valid?

The diagnosis must be recorded by an acceptable provider type during a face-to-face or audio-video encounter in the service year, with the note showing that the condition was monitored, evaluated, assessed or treated. Risk adjustment data validation audits recover payment for categories the record does not support, so the code on the claim and the assessment in the note must match.

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-02. Verify against the primary file before billing or contracting decisions.

Disclaimer

Relative factors and mappings are reproduced from the CMS risk adjustment model files as an operational reference. Payment depends on the plan's base rate, normalization, the coding intensity adjustment and the enrollee's segment. Not legal, clinical or billing advice.