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HCC 2: Septicemia, Sepsis, Systemic Inflammatory Response Syndrome/Shock

HCC 2, Septicemia, Sepsis, Systemic Inflammatory Response Syndrome/Shock, is one of the 115 payment categories in the CMS-HCC V28 model. 52 ICD-10-CM codes map to it in the payment year 2027 mapping, and a documented diagnosis in the category adds a relative factor of 0.500 to the risk score of a community, non-dual, aged beneficiary (0.598 disabled, 0.605 institutional). It sits at the top of its hierarchy, so no other category overrides it.

QuickIntell editorial content · Legacy registry date · Review not verified

Data effective
Data currency: ICD-10-CM to HCC mapping PY2027 initial (effective dates of service 2026, payment year 2027); CMS-HCC V28 model software V2826.115.T2 (effective payment year 2027). Next CMS release: PY2027 midyear final mapping (spring 2027) and PY2028 proposed model (February 2027).
Mapped ICD-10-CM codes
52
Factor, community non-dual aged
0.500
Factor, institutional
0.605
Hierarchy
Top of hierarchy

Relative factors by segment

Each segment is a separate regression; the factor is added to the beneficiary's demographic factors and other categories, then normalized and reduced by the coding intensity adjustment before it meets the plan's base rate. A factor of 1.000 equals the expected cost of an average beneficiary.

CMS-HCC V28 relative factors for HCC 2 by model segment
SegmentModel codeRelative factor
Community, non-dual, agedCNA_HCC20.500
Community, non-dual, disabledCND_HCC20.598
Community, full-benefit dual, agedCFA_HCC20.649
Community, full-benefit dual, disabledCFD_HCC20.780
Community, partial-benefit dual, agedCPA_HCC20.447
Community, partial-benefit dual, disabledCPD_HCC20.591
Long-term institutionalINS_HCC20.605

Hierarchy

HCC 2 is not part of a hierarchy: it is paid whenever a mapped diagnosis is documented, independently of the beneficiary's other categories.

ICD-10-CM codes that map to HCC 2

52 codes map to this category in the PY2027 initial mapping, concentrated in the A41 (15), P36 (10), A40 (5), R65 (4), A39 (3), R57 (2) code families. Descriptions are the CMS mapping descriptions for the FY2026 code set; a code that is deleted or split in the October code update stays valid for dates of service before the change.

ICD-10-CM codes mapped to HCC 2 in the CMS PY2027 initial mapping
ICD-10-CMDescription
A021Salmonella sepsis
A207Septicemic plague
A227Anthrax sepsis
A267Erysipelothrix sepsis
A327Listerial sepsis
A392Acute meningococcemia
A393Chronic meningococcemia
A394Meningococcemia, unspecified
A400Sepsis due to streptococcus, group A
A401Sepsis due to streptococcus, group B
A403Sepsis due to Streptococcus pneumoniae
A408Other streptococcal sepsis
A409Streptococcal sepsis, unspecified
A4101Sepsis due to Methicillin susceptible Staphylococcus aureus
A4102Sepsis due to Methicillin resistant Staphylococcus aureus
A411Sepsis due to other specified staphylococcus
A412Sepsis due to unspecified staphylococcus
A413Sepsis due to Hemophilus influenzae
A414Sepsis due to anaerobes
A4150Gram-negative sepsis, unspecified
A4151Sepsis due to Escherichia coli [E. coli]
A4152Sepsis due to Pseudomonas
A4153Sepsis due to Serratia
A4154Sepsis due to Acinetobacter baumannii
A4159Other Gram-negative sepsis
A4181Sepsis due to Enterococcus
A4189Other specified sepsis
A419Sepsis, unspecified organism
A427Actinomycotic sepsis
A483Toxic shock syndrome
A5486Gonococcal sepsis
B007Disseminated herpesviral disease
B377Candidal sepsis
M3581Multisystem inflammatory syndrome
P0270Newborn affected by fetal inflammatory response syndrome
P360Sepsis of newborn due to streptococcus, group B
P3610Sepsis of newborn due to unspecified streptococci
P3619Sepsis of newborn due to other streptococci
P362Sepsis of newborn due to Staphylococcus aureus
P3630Sepsis of newborn due to unspecified staphylococci
P3639Sepsis of newborn due to other staphylococci
P364Sepsis of newborn due to Escherichia coli
P365Sepsis of newborn due to anaerobes
P368Other bacterial sepsis of newborn
P369Bacterial sepsis of newborn, unspecified
R571Hypovolemic shock
R578Other shock
R6510Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction
R6511Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction
R6520Severe sepsis without septic shock
R6521Severe sepsis with septic shock
T794XXATraumatic shock, initial encounter

Where these codes sat in the V22 model

The V28 recalibration renumbered and regrouped categories; this table shows which legacy V22 categories the same ICD-10 codes belonged to, which is the quickest way to reconcile a V22-era HCC gap list with the current model.

V22 categories that the HCC 2 codes mapped to
V22 HCCCodes
251
1731

Capturing and defending the category

A category counts for a payment year when a mapped diagnosis is documented at least once during the data collection year by an acceptable provider type at a face-to-face or audio-video encounter, and when the note shows the condition was monitored, evaluated, assessed or treated. Chronic conditions do not carry forward: a category that is not re-documented in the year drops out of the score, which is why annual wellness visits and problem-list reconciliation are where most recapture happens. Risk adjustment data validation audits sample enrollees and ask for the medical record behind each submitted category; an unsupported category is removed and, under the extrapolation rules, the error rate is applied across the contract. The QuickIntell risk adjustment product surfaces suspected and unsupported categories from the chart, and the HCC hub lists every V28 category with its factor and code count.

Frequently asked questions

Which ICD-10 codes map to HCC 2?

52 ICD-10-CM codes map to HCC 2 in the CMS PY2027 initial mapping, for example A021 Salmonella sepsis; A207 Septicemic plague; A227 Anthrax sepsis; A267 Erysipelothrix sepsis. The full list is on this page; a code counts only when it is documented at a face-to-face or video encounter in the data collection year and supported by the record.

How much does HCC 2 add to a risk score?

The V28 relative factor for HCC 2 is 0.500 for a community, non-dual, aged beneficiary, 0.649 for full-benefit dual aged, 0.598 for non-dual disabled and 0.605 for long-term institutional members. A factor of 1.000 equals the expected annual cost of an average beneficiary, so the category's share of the payment follows the plan's base rate for that segment.

Does HCC 2 count together with related categories?

HCC 2 is not part of a hierarchy, so it is paid whenever it is documented regardless of which other categories the beneficiary has.

What has to be documented for HCC 2 to be valid?

The diagnosis must be recorded by an acceptable provider type during a face-to-face or audio-video encounter in the service year, with the note showing that the condition was monitored, evaluated, assessed or treated. Risk adjustment data validation audits recover payment for categories the record does not support, so the code on the claim and the assessment in the note must match.

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-02. Verify against the primary file before billing or contracting decisions.

Disclaimer

Relative factors and mappings are reproduced from the CMS risk adjustment model files as an operational reference. Payment depends on the plan's base rate, normalization, the coding intensity adjustment and the enrollee's segment. Not legal, clinical or billing advice.