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ICD-10-CM category Z17: Estrogen, and other hormones and factors receptor status

Category Z17 is a heading in chapter 21 (Factors influencing health status and contact with health services (Z00-Z99)), section Estrogen, and other hormones and factors receptor status (Z17). It is not billable; report one of the 10 complete codes below.

Notes that apply to every Z17 code

Code first
  • malignant neoplasm, such as:
  • malignant neoplasm of breast (C50.-)
  • malignant neoplasm of ovary (C56.-)
Notes
  • Use one code, as available, for each receptor: Z17.0, Z17.1, Z17.2-, Z17.3-

Billable codes in Z17

Billable FY2027 ICD-10-CM codes in category Z17
CodeDescription
Z17.0Estrogen receptor positive status [ER+]
Z17.1Estrogen receptor negative status [ER-]
Z17.21Progesterone receptor positive status
Z17.22Progesterone receptor negative status
Z17.31Human epidermal growth factor receptor 2 positive status
Z17.32Human epidermal growth factor receptor 2 negative status
Z17.410Hormone receptor positive with human epidermal growth factor receptor 2 positive status
Z17.411Hormone receptor positive with human epidermal growth factor receptor 2 negative status
Z17.420Hormone receptor negative with human epidermal growth factor receptor 2 positive status
Z17.421Hormone receptor negative with human epidermal growth factor receptor 2 negative status

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-10. Verify against the primary file before billing or contracting decisions. The reference methodology explains how each figure is computed from these files.

Codes from the FY2027 ICD-10-CM files (all chapters). Report the code that matches the documentation and the Official Guidelines; this list is not coding advice.