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ICD-10-CM category Z15: Genetic susceptibility to disease

Category Z15 is a heading in chapter 21 (Factors influencing health status and contact with health services (Z00-Z99)), section Genetic carrier and genetic susceptibility to disease (Z14-Z15). It is not billable; report one of the 14 complete codes below.

Notes that apply to every Z15 code

Includes
  • confirmed abnormal gene
Excludes1 (never coded together)
  • chromosomal anomalies (Q90-Q99)
Use additional code
  • code, if applicable, for any associated family history of the disease (Z80-Z84)

Billable codes in Z15

Billable FY2027 ICD-10-CM codes in category Z15
CodeDescription
Z15.01Genetic susceptibility to malignant neoplasm of breast
Z15.02Genetic susceptibility to malignant neoplasm of ovary
Z15.03Genetic susceptibility to malignant neoplasm of prostate
Z15.04Genetic susceptibility to malignant neoplasm of endometrium
Z15.05Genetic susceptibility to malignant neoplasm of fallopian tube(s)
Z15.060Genetic susceptibility to colorectal cancer
Z15.068Genetic susceptibility to other malignant neoplasm of digestive system
Z15.07Genetic susceptibility to malignant neoplasm of urinary tract
Z15.09Genetic susceptibility to other malignant neoplasm
Z15.1Genetic susceptibility to epilepsy and neurodevelopmental disorders
Z15.2Genetic susceptibility to obesity
Z15.3Genetic susceptibility to kidney disease
Z15.81Genetic susceptibility to multiple endocrine neoplasia [MEN]
Z15.89Genetic susceptibility to other disease

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-10. Verify against the primary file before billing or contracting decisions. The reference methodology explains how each figure is computed from these files.

Codes from the FY2027 ICD-10-CM files (all chapters). Report the code that matches the documentation and the Official Guidelines; this list is not coding advice.