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ICD-10-CM category R65: Symptoms and signs specifically associated with systemic inflammation and infection

Category R65 is a heading in chapter 18 (Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99)), section General symptoms and signs (R50-R69). It is not billable; report one of the 4 complete codes below.

Billable codes in R65

Billable FY2027 ICD-10-CM codes in category R65
CodeDescription
R65.10Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction
R65.11Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction
R65.20Severe sepsis without septic shock
R65.21Severe sepsis with septic shock

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-10. Verify against the primary file before billing or contracting decisions. The reference methodology explains how each figure is computed from these files.

Codes from the FY2027 ICD-10-CM files (all chapters). Report the code that matches the documentation and the Official Guidelines; this list is not coding advice.