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ICD-10-CM category R53: Malaise and fatigue

Category R53 is a heading in chapter 18 (Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99)), section General symptoms and signs (R50-R69). It is not billable; report one of the 6 complete codes below.

Billable codes in R53

Billable FY2027 ICD-10-CM codes in category R53
CodeDescription
R53.0Neoplastic (malignant) related fatigue
R53.1Weakness
R53.2Functional quadriplegia
R53.81Other malaise
R53.82Chronic fatigue, unspecified
R53.83Other fatigue

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-10. Verify against the primary file before billing or contracting decisions. The reference methodology explains how each figure is computed from these files.

Codes from the FY2027 ICD-10-CM files (all chapters). Report the code that matches the documentation and the Official Guidelines; this list is not coding advice.