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ICD-10-CM F53.0: Postpartum depression

F53.0 is the billable ICD-10-CM code for postpartum depression, in category F53 (Mental and behavioral disorders associated with the puerperium, not elsewhere classified) of the Behavioral syndromes associated with physiological disturbances and physical factors section. As a principal diagnosis it groups to MS-DRG 881 Depressive Neuroses (MDC 19 MDC 19: Mental Diseases and Disorders). 16 LCD billing and coding articles list it as covered.

Compiled from CMS files by the QuickIntell RCM Editorial Team · Data effective · Method: reference methodology · Report a data correction

Data currency: ICD-10-CM code descriptions: FY2027 (effective October 1, 2026); IPPS Table 5 (MS-DRG weights): v44 FY2027 (final rule + CN3) (effective October 1, 2026); ICD-10-CM to HCC mapping: PY2027 initial ICD-10-CM mappings (dates of service 2026) (payment year 2027); Medicare Coverage Database billing and coding articles: MCD release October 8, 2026 (effective October 4, 2026). Next CMS release: FY2028 code files, effective October 1, 2027 for the ICD-10-CM code descriptions; FY2028 final rule (August 2027), effective October 1, 2027; an April 1 interim grouper update when CMS issues one for the IPPS Table 5 (MS-DRG weights); PY2028 advance notice (February 2027) and the PY2027 midyear final mapping (spring 2027) for the ICD-10-CM to HCC mapping; weekly, every Thursday for the Medicare Coverage Database billing and coding articles.

Code
F53.0
billable FY2027 ICD-10-CM code
Category
F53 Mental and behavioral disorders associated with the puerperium, not elsewhere classified
Chapter
5: Mental, Behavioral and Neurodevelopmental disorders (F01-F99)
CC/MCC (MS-DRG v44)
Neither
CMS-HCC V28
Not mapped
POA reporting
Required

Tabular list notes for F53.0

The tabular list has no notes on F53.0 itself; the notes below apply from its parent headings.

Inherited from F53 (Mental and behavioral disorders associated with the puerperium, not elsewhere classified)

Excludes1 (never coded together)
  • mood disorders with psychotic features (F30.2, F31.2, F31.5, F31.64, F32.3, F33.3)
  • postpartum dysphoria (O90.6)
  • psychosis in schizophrenia, schizotypal, delusional, and other psychotic disorders (F20-F29)

MS-DRG grouping when F53.0 is the principal diagnosis

MS-DRG v44 groups for F53.0 as principal diagnosis
MDCMS-DRGs
19 MDC 19: Mental Diseases and Disorders881

The final group also depends on procedures, secondary diagnoses and discharge status; the MS-DRG lookup for F53.0 shows the full grouping logic.

CC/MCC status and inpatient edits

F53.0 is neither a CC nor an MCC under MS-DRG v44, so as a secondary diagnosis it does not raise the MS-DRG severity level. Check F53.0 against a principal diagnosis.

  • Present on admission: a POA indicator is required on inpatient claims.
  • Medicare Code Editor: age conflict: maternity diagnosis (age 9 to 64).

CMS-HCC V28 risk adjustment

F53.0 does not map to a payment HCC in the PY2027 CMS-HCC V28 model, so on its own it does not change a Medicare Advantage risk score.

LCD billing and coding articles that list F53.0

16 current Medicare billing and coding articles list F53.0 among the diagnoses that support medical necessity for the services they cover.

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Frequently asked questions

What does ICD-10-CM F53.0 mean?

F53.0 means postpartum depression. It is one of 2 billable codes under F53, mental and behavioral disorders associated with the puerperium, not elsewhere classified.

What can't be coded with F53.0?

Excludes1 at F53: mood disorders with psychotic features (F30.2, F31.2, F31.5, F31.64, F32.3, F33.3); postpartum dysphoria (O90.6); psychosis in schizophrenia, schizotypal, delusional, and other psychotic disorders (F20-F29). These are never reported together with F53.0.

Which MS-DRG does F53.0 group to?

As the principal diagnosis, F53.0 groups to MS-DRG 881 Depressive Neuroses (MDC 19 MDC 19: Mental Diseases and Disorders) under MS-DRG v44, before procedures and secondary diagnoses are applied.

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-10. Verify against the primary file before billing or contracting decisions. The reference methodology explains how each figure is computed from these files.

Disclaimer

The descriptor and notes are reproduced from the FY2027 ICD-10-CM files; MS-DRG, CC/MCC and HCC facts come from the CMS FY2027 and PY2027 tables. Code from the medical record and the ICD-10-CM Official Guidelines. Not legal, clinical or billing advice.

Found a figure that does not match the CMS file? Report a data correction with the CMS file and the value you expected; the request reaches the editorial team through the contact form.