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ICD-10-CM F33.40: Major depressive disorder, recurrent, in remission, unspecified

F33.40 is the billable ICD-10-CM code for major depressive disorder, recurrent, in remission, unspecified, in category F33 (Major depressive disorder, recurrent) of the Mood [affective] disorders section. As a principal diagnosis it groups to MS-DRG 885 Psychoses (MDC 19 MDC 19: Mental Diseases and Disorders). As a secondary diagnosis it is a CC, excluded with 12 principal diagnoses. 7 LCD billing and coding articles list it as covered.

Compiled from CMS files by the QuickIntell RCM Editorial Team · Data effective · Method: reference methodology · Report a data correction

Data currency: ICD-10-CM code descriptions: FY2027 (effective October 1, 2026); IPPS Table 5 (MS-DRG weights): v44 FY2027 (final rule + CN3) (effective October 1, 2026); ICD-10-CM to HCC mapping: PY2027 initial ICD-10-CM mappings (dates of service 2026) (payment year 2027); Medicare Coverage Database billing and coding articles: MCD release October 8, 2026 (effective October 4, 2026). Next CMS release: FY2028 code files, effective October 1, 2027 for the ICD-10-CM code descriptions; FY2028 final rule (August 2027), effective October 1, 2027; an April 1 interim grouper update when CMS issues one for the IPPS Table 5 (MS-DRG weights); PY2028 advance notice (February 2027) and the PY2027 midyear final mapping (spring 2027) for the ICD-10-CM to HCC mapping; weekly, every Thursday for the Medicare Coverage Database billing and coding articles.

Code
F33.40
billable FY2027 ICD-10-CM code
Category
F33 Major depressive disorder, recurrent
Chapter
5: Mental, Behavioral and Neurodevelopmental disorders (F01-F99)
CC/MCC (MS-DRG v44)
CC
CMS-HCC V28
Not mapped
POA reporting
Required

Tabular list notes for F33.40

The tabular list has no notes on F33.40 itself; the notes below apply from its parent headings.

Inherited from F33 (Major depressive disorder, recurrent)

Includes
  • recurrent episodes of depressive reaction
  • recurrent episodes of endogenous depression
  • recurrent episodes of major depression
  • recurrent episodes of psychogenic depression
  • recurrent episodes of reactive depression
  • recurrent episodes of seasonal affective disorder
  • recurrent episodes of seasonal depressive disorder
  • recurrent episodes of vital depression
Excludes1 (never coded together)
  • bipolar disorder (F31.-)
  • manic episode (F30.-)

MS-DRG grouping when F33.40 is the principal diagnosis

MS-DRG v44 groups for F33.40 as principal diagnosis
MDCMS-DRGs
19 MDC 19: Mental Diseases and Disorders885

The final group also depends on procedures, secondary diagnoses and discharge status; the MS-DRG lookup for F33.40 shows the full grouping logic.

CC/MCC status and inpatient edits

As a secondary diagnosis, F33.40 is a CC under MS-DRG v44, unless the principal diagnosis is one of the 12 codes in its exclusion list. Check F33.40 against a principal diagnosis.

  • Present on admission: a POA indicator is required on inpatient claims.

CMS-HCC V28 risk adjustment

F33.40 does not map to a payment HCC in the PY2027 CMS-HCC V28 model, so on its own it does not change a Medicare Advantage risk score.

LCD billing and coding articles that list F33.40

7 current Medicare billing and coding articles list F33.40 among the diagnoses that support medical necessity for the services they cover.

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Frequently asked questions

What does ICD-10-CM F33.40 mean?

F33.40 means major depressive disorder, recurrent, in remission, unspecified. It is one of 9 billable codes under F33, major depressive disorder, recurrent.

Which MS-DRG does F33.40 group to?

As the principal diagnosis, F33.40 groups to MS-DRG 885 Psychoses (MDC 19 MDC 19: Mental Diseases and Disorders) under MS-DRG v44, before procedures and secondary diagnoses are applied.

Is F33.40 a CC or MCC?

F33.40 is a CC under MS-DRG v44; 12 principal diagnoses exclude it.

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-10. Verify against the primary file before billing or contracting decisions. The reference methodology explains how each figure is computed from these files.

Disclaimer

The descriptor and notes are reproduced from the FY2027 ICD-10-CM files; MS-DRG, CC/MCC and HCC facts come from the CMS FY2027 and PY2027 tables. Code from the medical record and the ICD-10-CM Official Guidelines. Not legal, clinical or billing advice.

Found a figure that does not match the CMS file? Report a data correction with the CMS file and the value you expected; the request reaches the editorial team through the contact form.