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ICD-10-CM C92.12: Chronic myeloid leukemia, BCR/ABL-positive, in relapse

C92.12 is the billable ICD-10-CM code for chronic myeloid leukemia, BCR/ABL-positive, in relapse, in category C92 (Myeloid leukemia) of the Malignant neoplasms of lymphoid, hematopoietic and related tissue section. As a principal diagnosis it groups to MS-DRG 820 Lymphoma and Leukemia with Major O.R. Procedures with MCC, MS-DRG 821 Lymphoma and Leukemia with Major O.R. Procedures with CC, MS-DRG 822 Lymphoma and Leukemia with Major O.R. Procedures without CC/MCC (MDC 17 MDC 17: Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms). It maps to HCC 22 (Bladder, Colorectal, and Other Cancers) in CMS-HCC V28. As a secondary diagnosis it is a CC, excluded with 113 principal diagnoses. 35 LCD billing and coding articles list it as covered.

Compiled from CMS files by the QuickIntell RCM Editorial Team · Data effective · Method: reference methodology · Report a data correction

Data currency: ICD-10-CM code descriptions: FY2027 (effective October 1, 2026); IPPS Table 5 (MS-DRG weights): v44 FY2027 (final rule + CN3) (effective October 1, 2026); ICD-10-CM to HCC mapping: PY2027 initial ICD-10-CM mappings (dates of service 2026) (payment year 2027); Medicare Coverage Database billing and coding articles: MCD release October 8, 2026 (effective October 4, 2026). Next CMS release: FY2028 code files, effective October 1, 2027 for the ICD-10-CM code descriptions; FY2028 final rule (August 2027), effective October 1, 2027; an April 1 interim grouper update when CMS issues one for the IPPS Table 5 (MS-DRG weights); PY2028 advance notice (February 2027) and the PY2027 midyear final mapping (spring 2027) for the ICD-10-CM to HCC mapping; weekly, every Thursday for the Medicare Coverage Database billing and coding articles.

Code
C92.12
billable FY2027 ICD-10-CM code
Category
C92 Myeloid leukemia
Chapter
2: Neoplasms (C00-D49)
CC/MCC (MS-DRG v44)
CC
CMS-HCC V28
HCC 22
POA reporting
Required

Tabular list notes for C92.12

The tabular list has no notes on C92.12 itself; the notes below apply from its parent headings.

Inherited from C92 (Myeloid leukemia)

Includes
  • granulocytic leukemia
  • myelogenous leukemia
Excludes1 (never coded together)
  • personal history of leukemia (Z85.6)
Code also
  • , if applicable, pancytopenia (acquired) (D61.818)

Inherited from C92.1 (Chronic myeloid leukemia, BCR/ABL-positive)

Inclusion terms
  • Chronic myelogenous leukemia, Philadelphia chromosome (Ph1) positive
  • Chronic myelogenous leukemia, t(9;22) (q34;q11)
  • Chronic myelogenous leukemia with crisis of blast cells
Excludes1 (never coded together)
  • atypical chronic myeloid leukemia BCR/ABL-negative (C92.2-)
  • chronic myelomonocytic leukemia (C93.1-)
  • chronic myeloproliferative disease (D47.1)

MS-DRG grouping when C92.12 is the principal diagnosis

MS-DRG v44 groups for C92.12 as principal diagnosis
MDCMS-DRGs
17 MDC 17: Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms820821822823824825840841842

The final group also depends on procedures, secondary diagnoses and discharge status; the MS-DRG lookup for C92.12 shows the full grouping logic.

CC/MCC status and inpatient edits

As a secondary diagnosis, C92.12 is a CC under MS-DRG v44, unless the principal diagnosis is one of the 113 codes in its exclusion list. Check C92.12 against a principal diagnosis.

  • Present on admission: a POA indicator is required on inpatient claims.

CMS-HCC V28 risk adjustment

In the PY2027 mapping, C92.12 maps to HCC 22 (Bladder, Colorectal, and Other Cancers). The HCC lookup shows the RAF weight and the hierarchy.

LCD billing and coding articles that list C92.12

35 current Medicare billing and coding articles list C92.12 among the diagnoses that support medical necessity for the services they cover.

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Frequently asked questions

What does ICD-10-CM C92.12 mean?

C92.12 means chronic myeloid leukemia, BCR/ABL-positive, in relapse. It is one of 25 billable codes under C92, myeloid leukemia.

What can't be coded with C92.12?

Excludes1 at C92.1: atypical chronic myeloid leukemia BCR/ABL-negative (C92.2-); chronic myelomonocytic leukemia (C93.1-); chronic myeloproliferative disease (D47.1). These are never reported together with C92.12.

Which MS-DRG does C92.12 group to?

As the principal diagnosis, C92.12 groups to MS-DRG 820 Lymphoma and Leukemia with Major O.R. Procedures with MCC, MS-DRG 821 Lymphoma and Leukemia with Major O.R. Procedures with CC, MS-DRG 822 Lymphoma and Leukemia with Major O.R. Procedures without CC/MCC (MDC 17 MDC 17: Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms) under MS-DRG v44, before procedures and secondary diagnoses are applied.

Does C92.12 map to an HCC?

Yes: HCC 22, Bladder, Colorectal, and Other Cancers, in the PY2027 CMS-HCC V28 mapping.

Is C92.12 a CC or MCC?

C92.12 is a CC under MS-DRG v44; 113 principal diagnoses exclude it.

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-10. Verify against the primary file before billing or contracting decisions. The reference methodology explains how each figure is computed from these files.

Disclaimer

The descriptor and notes are reproduced from the FY2027 ICD-10-CM files; MS-DRG, CC/MCC and HCC facts come from the CMS FY2027 and PY2027 tables. Code from the medical record and the ICD-10-CM Official Guidelines. Not legal, clinical or billing advice.

Found a figure that does not match the CMS file? Report a data correction with the CMS file and the value you expected; the request reaches the editorial team through the contact form.