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ICD-10-CM C83.398: Diffuse large B-cell lymphoma of other extranodal and solid organ sites

C83.398 is the billable ICD-10-CM code for diffuse large B-cell lymphoma of other extranodal and solid organ sites, in category C83 (Non-follicular lymphoma) of the Malignant neoplasms of lymphoid, hematopoietic and related tissue section. As a principal diagnosis it groups to MS-DRG 820 Lymphoma and Leukemia with Major O.R. Procedures with MCC, MS-DRG 821 Lymphoma and Leukemia with Major O.R. Procedures with CC, MS-DRG 822 Lymphoma and Leukemia with Major O.R. Procedures without CC/MCC (MDC 17 MDC 17: Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms); or MS-DRG 974 HIV with Major Related Condition with MCC, MS-DRG 975 HIV with Major Related Condition with CC, MS-DRG 976 HIV with Major Related Condition without CC/MCC (MDC 25 MDC 25: Human Immunodeficiency Virus Infections). It maps to HCC 20 (Lung and Other Severe Cancers) in CMS-HCC V28. As a secondary diagnosis it is a CC, excluded with 15 principal diagnoses. 46 LCD billing and coding articles list it as covered.

Compiled from CMS files by the QuickIntell RCM Editorial Team · Data effective · Method: reference methodology · Report a data correction

Data currency: ICD-10-CM code descriptions: FY2027 (effective October 1, 2026); IPPS Table 5 (MS-DRG weights): v44 FY2027 (final rule + CN3) (effective October 1, 2026); ICD-10-CM to HCC mapping: PY2027 initial ICD-10-CM mappings (dates of service 2026) (payment year 2027); Medicare Coverage Database billing and coding articles: MCD release October 8, 2026 (effective October 4, 2026). Next CMS release: FY2028 code files, effective October 1, 2027 for the ICD-10-CM code descriptions; FY2028 final rule (August 2027), effective October 1, 2027; an April 1 interim grouper update when CMS issues one for the IPPS Table 5 (MS-DRG weights); PY2028 advance notice (February 2027) and the PY2027 midyear final mapping (spring 2027) for the ICD-10-CM to HCC mapping; weekly, every Thursday for the Medicare Coverage Database billing and coding articles.

Code
C83.398
billable FY2027 ICD-10-CM code
Category
C83 Non-follicular lymphoma
Chapter
2: Neoplasms (C00-D49)
CC/MCC (MS-DRG v44)
CC
CMS-HCC V28
HCC 20
POA reporting
Required

Tabular list notes for C83.398

The tabular list has no notes on C83.398 itself; the notes below apply from its parent headings.

Inherited from C83 (Non-follicular lymphoma)

Excludes1 (never coded together)
  • personal history of non-Hodgkin lymphoma (Z85.72)

Inherited from C83.3 (Diffuse large B-cell lymphoma)

Inclusion terms
  • Anaplastic diffuse large B-cell lymphoma
  • CD30-positive diffuse large B-cell lymphoma
  • Centroblastic diffuse large B-cell lymphoma
  • Diffuse large B-cell lymphoma, subtype not specified
  • Immunoblastic diffuse large B-cell lymphoma
  • Plasmablastic diffuse large B-cell lymphoma
  • T-cell rich diffuse large B-cell lymphoma
Excludes1 (never coded together)
  • mediastinal (thymic) large B-cell lymphoma (C85.2-)
  • mature T/NK-cell lymphomas (C84.-)

MS-DRG grouping when C83.398 is the principal diagnosis

MS-DRG v44 groups for C83.398 as principal diagnosis
MDCMS-DRGs
17 MDC 17: Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms820821822823824825840841842
25 MDC 25: Human Immunodeficiency Virus Infections974975976

The final group also depends on procedures, secondary diagnoses and discharge status; the MS-DRG lookup for C83.398 shows the full grouping logic.

CC/MCC status and inpatient edits

As a secondary diagnosis, C83.398 is a CC under MS-DRG v44, unless the principal diagnosis is one of the 15 codes in its exclusion list. Check C83.398 against a principal diagnosis.

  • Present on admission: a POA indicator is required on inpatient claims.

CMS-HCC V28 risk adjustment

In the PY2027 mapping, C83.398 maps to HCC 20 (Lung and Other Severe Cancers). The HCC lookup shows the RAF weight and the hierarchy.

LCD billing and coding articles that list C83.398

46 current Medicare billing and coding articles list C83.398 among the diagnoses that support medical necessity for the services they cover.

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Frequently asked questions

What does ICD-10-CM C83.398 mean?

C83.398 means diffuse large B-cell lymphoma of other extranodal and solid organ sites. It is one of 25 billable codes under C83, non-follicular lymphoma.

Which MS-DRG does C83.398 group to?

As the principal diagnosis, C83.398 groups to MS-DRG 820 Lymphoma and Leukemia with Major O.R. Procedures with MCC, MS-DRG 821 Lymphoma and Leukemia with Major O.R. Procedures with CC, MS-DRG 822 Lymphoma and Leukemia with Major O.R. Procedures without CC/MCC (MDC 17 MDC 17: Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms); or MS-DRG 974 HIV with Major Related Condition with MCC, MS-DRG 975 HIV with Major Related Condition with CC, MS-DRG 976 HIV with Major Related Condition without CC/MCC (MDC 25 MDC 25: Human Immunodeficiency Virus Infections) under MS-DRG v44, before procedures and secondary diagnoses are applied.

Does C83.398 map to an HCC?

Yes: HCC 20, Lung and Other Severe Cancers, in the PY2027 CMS-HCC V28 mapping.

Is C83.398 a CC or MCC?

C83.398 is a CC under MS-DRG v44; 15 principal diagnoses exclude it.

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-10. Verify against the primary file before billing or contracting decisions. The reference methodology explains how each figure is computed from these files.

Disclaimer

The descriptor and notes are reproduced from the FY2027 ICD-10-CM files; MS-DRG, CC/MCC and HCC facts come from the CMS FY2027 and PY2027 tables. Code from the medical record and the ICD-10-CM Official Guidelines. Not legal, clinical or billing advice.

Found a figure that does not match the CMS file? Report a data correction with the CMS file and the value you expected; the request reaches the editorial team through the contact form.