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ICD-10-CM category C49: Malignant neoplasm of other connective and soft tissue

Category C49 is a heading in chapter 2 (Neoplasms (C00-D49)), section Malignant neoplasms of mesothelial and soft tissue (C45-C49). It is not billable; report one of the 20 complete codes below.

Notes that apply to every C49 code

Includes
  • malignant neoplasm of blood vessel
  • malignant neoplasm of bursa
  • malignant neoplasm of cartilage
  • malignant neoplasm of fascia
  • malignant neoplasm of fat
  • malignant neoplasm of ligament, except uterine
  • malignant neoplasm of lymphatic vessel
  • malignant neoplasm of muscle
  • malignant neoplasm of synovia
  • malignant neoplasm of tendon (sheath)
Excludes1 (never coded together)
  • malignant neoplasm of cartilage (of):
  • articular (C40-C41)
  • larynx (C32.3)
  • nose (C30.0)
  • malignant neoplasm of connective tissue of breast (C50.-)
Excludes2 (not part of this condition, may be coded together)
  • Kaposi's sarcoma of soft tissue (C46.1)
  • malignant neoplasm of heart (C38.0)
  • malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-)
  • malignant neoplasm of peritoneum (C48.2)
  • malignant neoplasm of retroperitoneum (C48.0)
  • malignant neoplasm of uterine ligament (C57.3)
  • mesothelioma (C45.-)

Billable codes in C49

Billable FY2027 ICD-10-CM codes in category C49
CodeDescription
C49.0Malignant neoplasm of connective and soft tissue of head, face and neck
C49.10Malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder
C49.11Malignant neoplasm of connective and soft tissue of right upper limb, including shoulder
C49.12Malignant neoplasm of connective and soft tissue of left upper limb, including shoulder
C49.20Malignant neoplasm of connective and soft tissue of unspecified lower limb, including hip
C49.21Malignant neoplasm of connective and soft tissue of right lower limb, including hip
C49.22Malignant neoplasm of connective and soft tissue of left lower limb, including hip
C49.3Malignant neoplasm of connective and soft tissue of thorax
C49.4Malignant neoplasm of connective and soft tissue of abdomen
C49.5Malignant neoplasm of connective and soft tissue of pelvis
C49.6Malignant neoplasm of connective and soft tissue of trunk, unspecified
C49.8Malignant neoplasm of overlapping sites of connective and soft tissue
C49.9Malignant neoplasm of connective and soft tissue, unspecified
C49.A0Gastrointestinal stromal tumor, unspecified site
C49.A1Gastrointestinal stromal tumor of esophagus
C49.A2Gastrointestinal stromal tumor of stomach
C49.A3Gastrointestinal stromal tumor of small intestine
C49.A4Gastrointestinal stromal tumor of large intestine
C49.A5Gastrointestinal stromal tumor of rectum
C49.A9Gastrointestinal stromal tumor of other sites

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-10. Verify against the primary file before billing or contracting decisions. The reference methodology explains how each figure is computed from these files.

Codes from the FY2027 ICD-10-CM files (all chapters). Report the code that matches the documentation and the Official Guidelines; this list is not coding advice.