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Modifier EJ: Subsequent claims for a defined course of therapy, e.g., epo, sodium hyaluronate, infliximab

Modifier EJ is a HCPCS Level II modifier that CMS describes as "Subsequent claims for a defined course of therapy, e.g., epo, sodium hyaluronate, infliximab", in effect since January 1, 1991. 2 current Medicare billing and coding articles list it.

Compiled from CMS files by the QuickIntell RCM Editorial Team · Data effective · Method: reference methodology · Report a data correction

Data currency: HCPCS Level II file: October 2026 (effective October 1, 2026); Medicare Coverage Database billing and coding articles: MCD release October 8, 2026 (effective October 4, 2026); DMEPOS fee schedule: DME26-D (October 2026) (effective October 1, 2026). Next CMS release: January 1, 2027 (quarterly update) for the HCPCS Level II file and DMEPOS fee schedule; weekly, every Thursday for the Medicare Coverage Database billing and coding articles.

Modifier
EJ
Code set
HCPCS Level II
CMS October 2026 HCPCS file
In effect since
January 1, 1991
Medicare coverage articles
2
current MCD billing and coding articles that list it
DMEPOS fee schedule rows
None
DME26-D

CMS descriptor for modifier EJ

Subsequent claims for a defined course of therapy, e.g., epo, sodium hyaluronate, infliximab

CMS HCPCS Level II file, October 2026 (short descriptor: Subsequent claim)

When modifier EJ is used

EJ identifies subsequent claims in a defined course of therapy, for example the second and later injections in a series of hyaluronan knee injections or continued ESA therapy. Contractors use it to apply course-of-therapy limits.

Medicare coverage articles that list modifier EJ

2 current billing and coding articles in the Medicare Coverage Database name modifier EJ. Each one sets the contractor's rule for when the modifier is required or accepted.

Denials when modifier EJ is wrong or missing

A modifier that does not fit the procedure code comes back with claim adjustment reason code 4 (the procedure code is inconsistent with the modifier used, or a required modifier is missing). When a coverage article requires the modifier and it is absent, the line is usually returned as unprocessable with reason code 16 and a remark code naming the missing information, which is fixed with a corrected claim rather than an appeal. The denial code lookup explains each code.

For teams evaluating QuickIntell software

Where QuickIntell fits with modifiers

QuickCode supports qualified coder review, documentation clarification and the billing handoff, where each modifier is matched to what the record supports. QuickRCM carries claim readiness and the modifier-related denials with configurable automation and human review.

See QuickCode for modifier reviewSee QuickRCM for modifier denials
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Optional software evaluation, not payer support or help with an individual claim. For coverage or payment decisions, use the official sources on this page. Do not include patient information in a demo booking or inquiry.

Frequently asked questions

What does modifier EJ mean?

CMS describes modifier EJ as "Subsequent claims for a defined course of therapy, e.g., epo, sodium hyaluronate, infliximab" in the HCPCS Level II file. EJ identifies subsequent claims in a defined course of therapy, for example the second and later injections in a series of hyaluronan knee injections or continued ESA therapy.

Is modifier EJ still valid?

Yes. Modifier EJ is active in the CMS October 2026 HCPCS file; CMS added it on January 1, 1991. Payers can still decline to accept it, so check the payer's modifier policy.

Do Medicare coverage articles require modifier EJ?

2 current billing and coding articles in the Medicare Coverage Database name modifier EJ. Where an article covers the service, it sets the contractor's rule for when the modifier must be reported.

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-10. Verify against the primary file before billing or contracting decisions. The reference methodology explains how each figure is computed from these files.

Disclaimer

The descriptor is reproduced from the CMS HCPCS file; the note on when the modifier is used is our own summary of the Medicare rule. Medicaid and commercial plans publish their own modifier policies. Not legal, clinical or billing advice.

Found a figure that does not match the CMS file? Report a data correction with the CMS file and the value you expected; the request reaches the editorial team through the contact form.