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Skin substitute codes (Q4101-Q4399 and A2001-A2050)

333 active HCPCS Level II codes from the A (transportation, medical and surgical supplies, administrative, miscellaneous and investigational); Q (temporary codes) sections, each with its own reference page built from the October 2026 CMS files. Of these, 289 are priced on the physician fee schedule, 288 have an OPPS payment rate and 25 are listed in an LCD or billing article; 10 have enough joined data and search demand to be indexed.

Compiled from CMS files by the QuickIntell RCM Editorial Team · Data effective · Method: reference methodology · Report a data correction

Data currency: HCPCS Level II file: October 2026 (effective October 1, 2026); PFS relative value file: RVU26D, released August 26, 2026 (effective October 1, 2026); DMEPOS fee schedule: DME26-D (October 2026) (effective October 1, 2026); NCCI MUE tables: 2026 Q4 (effective October 1, 2026); NCCI PTP edits: v323r0 (2026 Q4) (effective October 1, 2026); OPPS Addendum B: October 2026 (effective October 1, 2026). Next CMS release: January 1, 2027 (quarterly update) for the HCPCS Level II file and DMEPOS fee schedule and NCCI MUE tables and NCCI PTP edits and OPPS Addendum B; RVU27A with the CY2027 PFS final rule, effective January 1, 2027 for the PFS relative value file.

Most searched codes in this range

Monthly US Google searches for the bare code (Google Ads, measured October 9, 2026) show which codes coders and billers look up most; search demand is one input to which pages are indexed and which the hub lists first.

Skin substitute codes (Q4101-Q4399 and A2001-A2050): codes with the most Google searches
CodeShort descriptorMedicare amountSearches / month
A2014Omeza collag compl 100 mg—720
A2020Ac5 wound system—390
A2032Myriad matrix, per sq cm$127.26210
A2001Innovamatrix ac, per sq cm$127.26170
A2010Apis, per square centimeter$127.26170
A2012Suprathel, per sq cm$127.26170
A2015Phoenix wnd mtrx, per sq cm$127.26170
A2019Kerecis marigen shld sq cm$127.26170
Q4186Epifix 1 sq cm$127.26170
A2008Theragenesis, per sq cm$127.26140

Codes in this range

The table lists the 10 codes in this range whose reference pages are indexed; the other 323 active codes follow as a list and keep their own pages for lookups. The Medicare amount is the national figure the page leads with.

Skin substitute codes (Q4101-Q4399 and A2001-A2050) with an indexed reference page
CodeDescriptorMedicare amountBasisMUE (setting)OPPS SI
A2001Innovamatrix ac, per square centimeter (add-on, list separately in addition to primary procedure)$127.26PFS non-facility—S1
Q4101Apligraf, per square centimeter (add-on, list separately in addition to primary procedure)$127.26PFS non-facility—S1
Q4133Grafix prime, grafixpl prime, stravix and stravixpl, per square centimeter (add-on, list separately in addition to primary procedure)$127.26PFS non-facility—S1
Q4158Kerecis omega3, per square centimeter (add-on, list separately in addition to primary procedure)$127.26PFS non-facility—S1
Q4159Affinity, per square centimeter (add-on, list separately in addition to primary procedure)$127.26PFS non-facility—S1
Q4186Epifix, per square centimeter (add-on, list separately in addition to primary procedure)$127.26PFS non-facility—S1
Q4191Restorigin, per square centimeter (add-on, list separately in addition to primary procedure)$127.26PFS non-facility—S1
Q4206Fluid flow or fluid gf, 1 cc—none in these files—N
Q4221Amniowrap2, per square centimeter (add-on, list separately in addition to primary procedure)$127.26PFS non-facility—S1
Q4250Amnioamp-mp, per square centimeter (add-on, list separately in addition to primary procedure)$127.26PFS non-facility—S1
Show the other 323 codes (pages not in search results)
  • A2002 Mirragen adv wnd mat per sq
  • A2004 Xcellistem, 1 mg
  • A2005 Microlyte matrix, per sq cm
  • A2006 Novosorb synpath per sq cm
  • A2007 Restrata, per sq cm
  • A2008 Theragenesis, per sq cm
  • A2009 Symphony, per sq cm
  • A2010 Apis, per square centimeter
  • A2011 Supra sdrm, per sq cm
  • A2012 Suprathel, per sq cm
  • A2013 Innovamatrix fs, per sq cm
  • A2014 Omeza collag compl 100 mg
  • A2015 Phoenix wnd mtrx, per sq cm
  • A2016 Permeaderm b, per sq cm
  • A2017 Permeaderm glove, each
  • A2018 Permeaderm c, per sq cm
  • A2019 Kerecis marigen shld sq cm
  • A2020 Ac5 wound system
  • A2021 Neomatrix per sq cm
  • A2022 Innovabrn/innovamatx xl sqcm
  • A2023 Innovamatrix pd, 1 mg
  • A2024 Resolve or xenopatch sq cm
  • A2025 Miro3d per cubic cm
  • A2026 Restrata minimatrix, 5 mg
  • A2027 Matriderm per sq cm
  • A2028 Micromatrix flex per mg
  • A2029 Mirotract matrix sheet
  • A2030 Miro3d fibers, per mg
  • A2031 Mirodry, per sq cm
  • A2032 Myriad matrix, per sq cm
  • A2033 Myriad morcells, 4 mg
  • A2034 Found drs solo, per sq cm
  • A2035 Corpl p therac p allac p mg
  • A2036 Cohealyx col dml mx pr sq cm
  • A2037 G4derm plus/suprello, pr ml
  • A2038 Marigen pacto, per sq cm
  • A2039 Innovamatrix fd, per sq cm
  • A2040 Microlyte painguard pr sq cm
  • A2041 Foundation drs+ duo pr sq cm
  • A2042 Foundation drs+ solo, sq cm
  • A2043 Biobrane, per sq cm
  • A2044 Biobrane glove, each
  • A2045 Novashield/novogen pr sq cm
  • A2046 Dermisphere hdrt, per sq cm
  • A2047 Lacertamatrix, per sq cm
  • A2048 Puraply mz, per mg
  • A2049 Theracor, per sq cm
  • A2050 Fibrillar collagen, per mg
  • Q4102 Oasis wound matrix
  • Q4103 Oasis burn matrix
  • Q4104 Integra bmwd
  • Q4105 Integra drt or omnigraft
  • Q4107 Graftjacket
  • Q4108 Integra matrix
  • Q4110 Primatrix
  • Q4111 Gammagraft
  • Q4112 Cymetra injectable
  • Q4113 Graftjacket xpress
  • Q4114 Integra flowable wound matri
  • Q4115 Alloskin
  • Q4116 Alloderm
  • Q4117 Hyalomatrix
  • Q4118 Matristem micromatrix
  • Q4121 Theraskin
  • Q4122 Dermacell, awm, porous sq cm
  • Q4123 Alloskin
  • Q4124 Oasis tri-layer wound matrix
  • Q4125 Arthroflex
  • Q4126 Memoderm/derma/tranz/integup
  • Q4127 Talymed
  • Q4128 Flexhd/allopatchhd/sq cm
  • Q4130 Strattice tm
  • Q4132 Grafix core, grafixpl core
  • Q4134 Hmatrix
  • Q4135 Mediskin
  • Q4136 Ezderm
  • Q4137 Amnioexcel biodexcel 1sq cm
  • Q4138 Biodfence dryflex, 1cm
  • Q4139 Amnio or biodmatrix, inj 1cc
  • Q4140 Biodfence 1cm
  • Q4141 Alloskin ac, 1 cm
  • Q4142 Xcm biologic tiss matrix 1cm
  • Q4143 Repriza, 1cm
  • Q4145 Epifix, inj, 1mg
  • Q4146 Tensix, 1cm
  • Q4147 Architect ecm px fx 1 sq cm
  • Q4148 Neox neox rt or clarix cord
  • Q4149 Excellagen, 0.1 cc
  • Q4150 Allowrap ds or dry 1 sq cm
  • Q4151 Amnioband, guardian 1 sq cm
  • Q4152 Dermapure 1 square cm
  • Q4153 Dermavest, plurivest sq cm
  • Q4154 Biovance 1 square cm
  • Q4155 Neoxflo or clarixflo 1 mg
  • Q4156 Neox 100 or clarix 100
  • Q4157 Revitalon 1 square cm
  • Q4160 Nushield 1 square cm
  • Q4161 Bio-connekt per square cm
  • Q4162 Wndex flw, bioskn flw, 0.5cc
  • Q4163 Woundex, bioskin, per sq cm
  • Q4164 Helicoll, per square cm
  • Q4165 Keramatrix, kerasorb sq cm
  • Q4166 Cytal, per square centimeter
  • Q4167 Truskin, per sq centimeter
  • Q4168 Amnioband, 1 mg
  • Q4169 Artacent wound, per sq cm
  • Q4170 Cygnus, per sq cm
  • Q4171 Interfyl, 1 mg
  • Q4173 Palingen or palingen xplus
  • Q4174 Palingen or promatrx
  • Q4175 Miroderm
  • Q4176 Neopatch or therion, 1 sq cm
  • Q4177 Floweramnioflo, 0.1 cc
  • Q4178 Floweramniopatch, per sq cm
  • Q4179 Flowerderm, per sq cm
  • Q4180 Revita, per sq cm
  • Q4181 Amnio wound, per square cm
  • Q4182 Transcyte, per sq centimeter
  • Q4183 Surgigraft, 1 sq cm
  • Q4184 Cellesta or duo per sq cm
  • Q4185 Cellesta flowab amnion 0.5cc
  • Q4187 Epicord 1 sq cm
  • Q4188 Amnioarmor 1 sq cm
  • Q4189 Artacent ac, 1 mg
  • Q4190 Artacent ac 1 sq cm
  • Q4192 Restorigin, 1 cc
  • Q4193 Coll-e-derm 1 sq cm
  • Q4194 Novachor 1 sq cm
  • Q4195 Puraply 1 sq cm
  • Q4196 Puraply am 1 sq cm
  • Q4197 Puraply xt 1 sq cm
  • Q4198 Genesis amnio membrane 1sqcm
  • Q4199 Cygnus matrix, per sq cm
  • Q4200 Skin te 1 sq cm
  • Q4201 Matrion 1 sq cm
  • Q4202 Keroxx (2.5g/cc), 1cc
  • Q4203 Derma-gide, 1 sq cm
  • Q4204 Xwrap 1 sq cm
  • Q4205 Membrane graft or wrap sq cm
  • Q4207 Carbon life, per sq cm
  • Q4208 Novafix per sq cm
  • Q4209 Surgraft per sq cm
  • Q4211 Amnion bio or axobio sq cm
  • Q4212 Allogen, per cc
  • Q4213 Ascent, 0.5 mg
  • Q4214 Cellesta cord per sq cm
  • Q4215 Axolotl ambient, cryo 0.1 mg
  • Q4216 Artacent cord per sq cm
  • Q4217 Woundfix biowound plus xplus
  • Q4218 Surgicord per sq cm
  • Q4219 Surgigraft dual per sq cm
  • Q4220 Bellacell hd, surederm sq cm
  • Q4222 Progenamatrix, per sq cm
  • Q4223 Dermabind sl optic per sq cm
  • Q4224 Hhf10-p per sq cm
  • Q4225 Amnio or derma tl, per sq cm
  • Q4226 Myown harv prep proc sq cm
  • Q4227 Amniocore per sq cm
  • Q4229 Cogenex amnio memb per sq cm
  • Q4230 Cogenex flow amnion 0.5 cc
  • Q4232 Corplex, per sq cm
  • Q4233 Surfactor /nudyn per 0.5 cc
  • Q4234 Xcellerate, per sq cm
  • Q4235 Amniorepair or altiply sq cm
  • Q4236 Carepatch per sq cm
  • Q4237 Cryo-cord, per sq cm
  • Q4238 Derm-maxx, per sq cm
  • Q4239 Amnio-maxx or lite per sq cm
  • Q4240 Corecyte topical only 0.5 cc
  • Q4241 Polycyte, topical only 0.5cc
  • Q4242 Amniocyte plus, per 0.5 cc
  • Q4243 Amchomatrix, per sq cm
  • Q4245 Amniotext, per cc
  • Q4246 Coretext or protext, per cc
  • Q4247 Amniotext patch, per sq cm
  • Q4248 Dermacyte amn mem allo sq cm
  • Q4249 Amniply, per sq cm
  • Q4251 Vim, per square centimeter
  • Q4252 Vendaje, per square centimet
  • Q4253 Zenith amniotic membrane psc
  • Q4254 Novafix dl per sq cm
  • Q4255 Reguard, topical use per sq
  • Q4256 Mlg complet, per sq cm
  • Q4257 Relese, per sq cm
  • Q4258 Enverse, per sq cm
  • Q4259 Celera per sq cm
  • Q4260 Signature apatch, per sq cm
  • Q4261 Tag, per square centimeter
  • Q4262 Dual layer impax, per sq cm
  • Q4263 Surgraft tl, per sq cm
  • Q4264 Cocoon membrane, per sq cm
  • Q4265 Neostim tl per sq cm
  • Q4266 Neostim per sq cm
  • Q4267 Neostim dl per sq cm
  • Q4268 Surgraft ft per sq cm
  • Q4269 Surgraft xt per sq cm
  • Q4270 Complete sl per sq cm
  • Q4271 Complete ft per sq cm
  • Q4272 Esano a, per sq cm
  • Q4273 Esano aaa, per sq cm
  • Q4274 Esano ac, per sq cm
  • Q4275 Esano aca, per sq cm
  • Q4276 Orion, per sq cm
  • Q4278 Epieffect, per sq cm
  • Q4279 Vendaje ac, per sq cm
  • Q4280 Xcell amnio matrix per sq cm
  • Q4281 Barrera slor dl per sq cm
  • Q4282 Cygnus dual per sq cm
  • Q4283 Biovance tri or 3l, sq cm
  • Q4284 Dermabind sl, per sq cm
  • Q4285 Nudyn dl or dl mesh pr sq cm
  • Q4286 Nudyn sl or slw, per sq cm
  • Q4287 Dermabind dl, per sq cm
  • Q4288 Dermabind ch, per sq cm
  • Q4289 Revoshield+ amnio, per sq cm
  • Q4290 Membrane wrap hydr per sq cm
  • Q4291 Lamellas xt, per sq cm
  • Q4292 Lamellas, per sq cm
  • Q4293 Acesso dl, per sq cm
  • Q4294 Amnio quad-core, per sq cm
  • Q4295 Amnio tri-core, per sq cm
  • Q4296 Rebound matrix, per sq cm
  • Q4297 Emerge matrix, per sq cm
  • Q4298 Amniocore pro, per sq cm
  • Q4299 Amniocore pro+, per sq cm
  • Q4300 Acesso tl, per sq cm
  • Q4301 Activate matrix, per sq cm
  • Q4302 Complete aca, per sq cm
  • Q4303 Complete aa, per sq cm
  • Q4304 Grafix plus, per sq cm
  • Q4305 Amer am ac tri-lay per sq cm
  • Q4306 Americ amnion ac per sq cm
  • Q4307 American amnion, per sq cm
  • Q4308 Sanopellis, per sq cm
  • Q4309 Via matrix, per sq cm
  • Q4310 Procenta, per 100 mg
  • Q4311 Acesso, per sq cm
  • Q4312 Acesso ac, per sq cm
  • Q4313 Dermabind fm, per sq cm
  • Q4314 Reeva, per sq cm
  • Q4315 Regenelink amniotic mem allo
  • Q4316 Amchoplast, per sq cm
  • Q4317 Vitograft, per sq cm
  • Q4318 E-graft, per sq cm
  • Q4319 Sanograft, per sq cm
  • Q4320 Pellograft, per sq cm
  • Q4321 Renograft, per sq cm
  • Q4322 Caregraft, per sq cm
  • Q4323 Alloply, per sq cm
  • Q4324 Amniotx, per sq cm
  • Q4325 Acapatch, per sq cm
  • Q4326 Woundplus, per sq cm
  • Q4327 Duoamnion, per sq cm
  • Q4328 Most, per sq cm
  • Q4329 Singlay, per sq cm
  • Q4330 Total, per sq cm
  • Q4331 Axolotl graft, per sq cm
  • Q4332 Axolotl dualgraft, per sq cm
  • Q4333 Ardeograft, per sq cm
  • Q4334 Amnioplast 1, per sq cm
  • Q4335 Amnioplast 2, per sq cm
  • Q4336 Artecent c, per sq cm
  • Q4337 Artecent trident, per sq cm
  • Q4338 Artacent velos, per sq cm
  • Q4339 Artacent vericlen, per sq cm
  • Q4340 Simpligraft, per sq cm
  • Q4341 Simplimax, per sq cm
  • Q4342 Theramend, per sq cm
  • Q4343 Dermacyte ac matrx per sq cm
  • Q4344 Tri membrane wrap, per sq cm
  • Q4345 Matrix hd allogrft per sq cm
  • Q4346 Shelter dm matrix per sq cm
  • Q4347 Rampart dl matrix per sq cm
  • Q4348 Sentry sl matrix per sq cm
  • Q4349 Mantle dl matrix per sq cm
  • Q4350 Palisade dm matrix per sq cm
  • Q4351 Enclose tl matrix, per sq cm
  • Q4352 Overlay sl matrix, per sq cm
  • Q4353 Xceed tl matrix per sq cm
  • Q4354 Palingen dl-palingen dl-x
  • Q4355 Abio xpl abio xpl hy p sq cm
  • Q4356 Abio mem abio hyd per sq cm
  • Q4357 Xwrap plus, per sq cm
  • Q4358 Xwrap dual, per sq cm
  • Q4359 Choriply, per sq cm
  • Q4360 Amchoplast fd per sq cm
  • Q4361 Epixpress, per sq cm
  • Q4362 Cygnus disk, per sq cm
  • Q4363 Am bur mem hydro per sq cm
  • Q4364 Am bur xp mem xpl hy p sq cm
  • Q4365 Amnio bur dl mem per sq cm
  • Q4366 Dl amnio bur x-mem per sq cm
  • Q4367 Amniocore sl, per sq cm
  • Q4368 Amchothick per sq cm
  • Q4369 Amnioplast 3 per sq cm
  • Q4370 Aeroguard per sq cm
  • Q4371 Neoguard per sq cm
  • Q4372 Amchoplast excl per sq cm
  • Q4373 Membrane wrp lt per sq cm
  • Q4375 Duograft ac per sq cm
  • Q4376 Duograft aa per sq cm
  • Q4377 Trigraft ft per sq cm
  • Q4378 Renew ft matrix per sq cm
  • Q4379 Amniodefend ft per sq cm
  • Q4380 Advograft one per sq cm
  • Q4382 Advograft dual per sq cm
  • Q4383 Axolotl graft ult per sq cm
  • Q4384 Axolotl dual ult per sq cm
  • Q4385 Apollo ft per sq cm
  • Q4386 Acesso trifaca per sq cm
  • Q4387 Neothelium ft per sq cm
  • Q4388 Neothelium 4l per sq cm
  • Q4389 Neothelium 4l+ per sq cm
  • Q4390 Ascendion per sq cm
  • Q4391 Amnioplast double per sq cm
  • Q4392 Grafix duo per sq cm
  • Q4393 Surgraft ac per sq cm
  • Q4394 Surgraft aca per sq cm
  • Q4395 Acelagraft per sq cm
  • Q4396 Natalin per sq cm
  • Q4397 Summit aaa per sq cm
  • Q4398 Summit ac per sq cm
  • Q4399 Summit fx per sq cm

How to read this table

The Medicare amount is a national figure from the October 2026 CMS files: for codes on the physician fee schedule it is the non-facility payment at the 2026 conversion factor, for DMEPOS items the national ceiling or, where competitive bidding sets the fees, the highest non-rural state fee, and for laboratory, hospital outpatient and ASC codes the published rate. Each code page shows the full breakdown, every modifier row and the state range. MUE is the Medically Unlikely Edit for the setting that bills the code, named in brackets: the DME supplier MUE for items on the DMEPOS fee schedule, the hospital outpatient MUE for codes with an OPPS payment rate but no national physician fee schedule amount, and the practitioner MUE otherwise; when that setting has no MUE, the next published one is shown. OPPS SI is the status indicator from Addendum B, which tells a hospital whether the code is paid separately, packaged, not payable under the outpatient system or, for status A, paid under another fee schedule or payment system. “None in these files” means none of the physician fee schedule, DMEPOS, lab, OPPS or ASC files lists a national amount; the code page says which payment rules apply. A dash means CMS publishes no value for that code in that file.

Where QuickIntell fits for Skin substitute codes (Q4101-Q4399 and A2001-A2050)

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Frequently asked questions

How many Skin substitute codes (Q4101-Q4399 and A2001-A2050) are there?

The October 2026 HCPCS Level II file has 333 active codes in this hub. 289 of them carry a national Medicare amount in a 2026 fee schedule or OPPS/ASC addendum; the highest is A2001 at $127.26 (PFS non-facility).

Are Skin substitute codes (Q4101-Q4399 and A2001-A2050) CPT codes?

No. They are HCPCS Level II codes, a letter followed by four digits, maintained by CMS; CPT codes are five-character codes maintained by the AMA. Both are reported in the same procedure-code field on Medicare claims.

How often do Skin substitute codes (Q4101-Q4399 and A2001-A2050) change?

CMS updates the HCPCS Level II file every quarter (January, April, July and October) and publishes the fee schedules, MUE and NCCI tables on the same quarterly cycle; this hub is rebuilt from each release.

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-10. Verify against the primary file before billing or contracting decisions. The reference methodology explains how each figure is computed from these files.

Disclaimer

Operational reference compiled from CMS publications. Amounts are Medicare national figures before locality and state adjustment; other payers differ. CPT codes appear as numbers only. Not legal, clinical or billing advice.

Found a figure that does not match the CMS file? Report a data correction with the CMS file and the value you expected; the request reaches the editorial team through the contact form.