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HCPCS J7515 · Level II · Part B drug

HCPCS J7515: Cyclosporine, oral, 25 mg

Reviewed by QuickIntell RCM Editorial Team · Last reviewed

Data effective
Data currency: ASP payment limits October 2026 (effective October 1, 2026); MUE and NCCI edits 2026 Q4 (effective October 1, 2026); OPPS Addendum B July 2026 (effective July 1, 2026). Next CMS release: January 1, 2027 (ASP, MUE, NCCI and OPPS quarterly updates).

Key facts for J7515

Billing unit
25 MG
Cyclosporine oral 25 mg
ASP payment limit
$0.576
October 2026; +4.4% vs July 2026
Practitioner MUE
0
MAI 3
OPPS status
SI N
NCCI exposure
no PTP pairs
Coverage articles
0
none list this code

TL;DR

HCPCS J7515 is the Level II code for Cyclosporine, oral, 25 mg, billed per 25 MG. The Medicare Part B ASP payment limit for October 2026 is $0.576 per billing unit, up 4.4% from July 2026. The practitioner MUE allows up to 0 units per date of service (MAI 3). Under OPPS it carries status indicator N. Oral drugs under Part B are payable only in the specific statutory categories (for example oral anticancer or antiemetic drugs with a self-administration exception), so the diagnosis and the regimen must match that category. The ASP crosswalk maps 10 NDCs to it, sold as Gengraf, Sandimmune, Neoral by AbbVie Inc., Novartis Pharmaceuticals Corporation, Teva Pharmaceuticals USA, Inc.. No current Billing and Coding Article lists J7515, so coverage follows the FDA label, compendia and any applicable NCD.

Medicare Part B payment limit (ASP)

CMS sets the Part B payment limit for J7515 at $0.576 per 25 MG for October 2026, derived from manufacturer average sales price plus 6%, compared with $0.552 in July 2026. Beneficiary coinsurance is 20%.

ASP payment limits for J7515
QuarterPayment limitPerCoinsurance
October 2026$0.57625 MG20%
July 2026$0.55225 MG—
Source: CMS Medicare Part B Drug Payment Limit File. Commercial and Medicaid payers set their own rates.

NDC to HCPCS billing-unit conversion

The October 2026 ASP crosswalk maps 10 NDCs from 6 labelers to J7515. Report the NDC in the claim's drug segment and bill the number of J7515 units that equals the quantity administered divided by 25 MG; the last column gives units per full package.

NDCs that crosswalk to J7515
NDCDrug nameLabelerPackage sizeBilling units / package
00074-3108-32GengrafAbbVie Inc.30 × 130
00078-0240-15SandimmuneNovartis Pharmaceuticals Corporation30 × 130
00078-0246-15NeoralNovartis Pharmaceuticals Corporation30 × 130
00093-9018-65CyclosporineTeva Pharmaceuticals USA, Inc.30 × 130
23155-0837-30CyclosporineHeritage Pharmaceuticals Inc.30 × 130
23155-0838-30CyclosporineHeritage Pharmaceuticals Inc.30 × 160
60505-0133-00CyclosporineApotex Corp30 × 130
60505-4630-03CyclosporineApotex Corp30 × 130
60505-4631-03CyclosporineApotex Corp30 × 160
68084-0879-25CyclosporineAmerican Health Packaging30 × 130

Medically Unlikely Edits (MUE)

CMS publishes 3 MUE values for J7515. For practitioners the limit is 0 units per date of service with adjudication indicator 3, a date-of-service clinical edit: units above the limit deny but can be paid on appeal with documentation that the quantity was medically reasonable.

MUE values for J7515 by setting
SettingMUE (units/DOS)MAICMS rationale
Practitioner services03 Date of Service Edit: ClinicalOral Medication; Not Payable
Facility outpatient hospital903 Date of Service Edit: ClinicalClinical: Data
DME supplier18003 Date of Service Edit: ClinicalCMS Policy

NCCI edits and add-on relationships

No active practitioner PTP pair lists J7515 as a column-1 or column-2 code in v323r0. Drug supply codes are rarely bundled; the administration codes billed with them are where PTP edits usually apply.

J7515 is neither an add-on code nor a designated primary code in the 2026 Q4 NCCI add-on edit file.

Medicare coverage articles

No current Billing and Coding Article lists J7515 in its HCPCS table. Coverage then follows the drug's FDA label, compendia and any National Coverage Determination; check the Medicare Coverage Database before administering off-label.

Hospital outpatient (OPPS) status

In the July 2026 OPPS Addendum B, J7515 carries status indicator N. Status N means payment is packaged into the associated procedure and no separate OPPS payment is made.

Common denials for J7515 and how to prevent them

CARC 16 · M119

NDC missing, invalid or not matched to the HCPCS code

CARC 151 · N362

units billed exceed the MUE for the date of service

CARC 50 · N115

diagnosis not covered by the applicable coverage article or LCD

How QuickIntell checks J7515 before the claim leaves

QuickCode validates the NDC-to-unit conversion against the current ASP crosswalk, checks units against every published MUE setting and flags PTP and add-on conflicts on the same claim. QuickRCM routes CARC 16, 151 and 50 denials on drug lines with the matching coverage article attached so the appeal starts with evidence.

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Frequently asked questions — HCPCS J7515

What does HCPCS code J7515 describe?

J7515 is defined by CMS as "Cyclosporine, oral, 25 mg". Each billing unit represents 25 MG, so the units reported on the claim must equal the dose administered divided by that unit.

What is the Medicare reimbursement for J7515 in October 2026?

The ASP-based payment limit is $0.576 per 25 MG, with 20% beneficiary coinsurance. Medicare Administrative Contractors apply this limit; commercial payers use their own fee schedules. The July 2026 limit was $0.552.

How many units of J7515 can be billed per day?

The practitioner Medically Unlikely Edit is 0 units per date of service with adjudication indicator 3 (3 Date of Service Edit: Clinical). MAI 3 edits can be appealed with documentation that the units were medically reasonable. CMS cites "Oral Medication; Not Payable" as the rationale.

Which NDCs map to J7515?

The October 2026 ASP crosswalk lists 10 NDCs from 6 labelers: Gengraf (AbbVie Inc.); Sandimmune (Novartis Pharmaceuticals Corporation); Neoral (Novartis Pharmaceuticals Corporation); Cyclosporine (Teva Pharmaceuticals USA, Inc.). For example NDC 00074-3108-32 is a 30 package equal to 30 billing units. The crosswalk's billing-units-per-package figure converts each package into J7515 units.

Does J7515 have NCCI bundling edits?

No active practitioner PTP pairs list J7515 as a column-1 or column-2 code in the v323r0 release. Unit limits (MUE) and medical-necessity coverage rules still apply.

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-01. Verify against the primary file before billing or contracting decisions.

Disclaimer

This page is an operational reference compiled from CMS publications: the Medicare Part B drug payment limit and NDC crosswalk files, NCCI MUE and add-on edit tables, aggregate PTP statistics, OPPS Addendum B and the Medicare Coverage Database. Payment limits are Medicare national amounts; commercial and Medicaid payers differ. CPT codes are shown as numbers only; CPT descriptors are copyright AMA. Nothing here is legal, clinical or billing advice.