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HCPCS J3465 · Level II · Part B drug

HCPCS J3465: Injection, voriconazole, 10 mg

Reviewed by QuickIntell RCM Editorial Team · Last reviewed

Data effective
Data currency: ASP payment limits October 2026 (effective October 1, 2026); MUE and NCCI edits 2026 Q4 (effective October 1, 2026); OPPS Addendum B July 2026 (effective July 1, 2026). Next CMS release: January 1, 2027 (ASP, MUE, NCCI and OPPS quarterly updates).

Key facts for J3465

Billing unit
10 MG
Injection, voriconazole
ASP payment limit
$0.548
October 2026; -2.7% vs July 2026
Practitioner MUE
40
MAI 3
OPPS status
SI N
NCCI exposure
no PTP pairs
Coverage articles
0
none list this code

TL;DR

HCPCS J3465 is the Level II code for Injection, voriconazole, 10 mg, billed per 10 MG. The Medicare Part B ASP payment limit for October 2026 is $0.548 per billing unit, down 2.7% from July 2026. The practitioner MUE allows up to 40 units per date of service (MAI 3). Under OPPS it carries status indicator N. The 10 mg billing unit means doses are reported in multiples of ten milligrams, with any remainder rounded per contractor policy; mismatched units against the NDC quantity trigger MUE and NDC-unit edits. The ASP crosswalk maps 10 NDCs to it, sold as Vfend Iv, Voriconazole by Pfizer Inc, Sandoz Inc., FreseniUS Kabi USA, LLC. No current Billing and Coding Article lists J3465, so coverage follows the FDA label, compendia and any applicable NCD.

Medicare Part B payment limit (ASP)

CMS sets the Part B payment limit for J3465 at $0.548 per 10 MG for October 2026, derived from manufacturer average sales price plus 6%, compared with $0.563 in July 2026. Beneficiary coinsurance is 20%.

ASP payment limits for J3465
QuarterPayment limitPerCoinsurance
October 2026$0.54810 MG20%
July 2026$0.56310 MG—
Source: CMS Medicare Part B Drug Payment Limit File. Commercial and Medicaid payers set their own rates.

NDC to HCPCS billing-unit conversion

The October 2026 ASP crosswalk maps 10 NDCs from 8 labelers to J3465. Report the NDC in the claim's drug segment and bill the number of J3465 units that equals the quantity administered divided by 10 MG; the last column gives units per full package.

NDCs that crosswalk to J3465
NDCDrug nameLabelerPackage sizeBilling units / package
00049-3190-01Vfend IvPfizer Inc1 × 120
00049-3190-28Vfend IvPfizer Inc1 × 120
00049-4190-01Vfend IvPfizer Inc1 × 120
00781-3416-94VoriconazoleSandoz Inc.1 × 120
65219-0190-30VoriconazoleFreseniUS Kabi USA, LLC1 × 120
70436-0029-80VoriconazoleSlate Run Pharmaceuticals1 × 120
70594-0067-01VoriconazoleXellia Pharmaceuticals USA, LLC.1 × 120
71288-0027-30VoriconazoleMeitheal Pharmaceuticals Inc.1 × 120
72266-0131-01VoriconazoleFosun Pharma USA Inc.1 × 120
72572-0875-01VoriconazoleCivica, Inc.1 × 120

Medically Unlikely Edits (MUE)

CMS publishes 3 MUE values for J3465. For practitioners the limit is 40 units per date of service with adjudication indicator 3, a date-of-service clinical edit: units above the limit deny but can be paid on appeal with documentation that the quantity was medically reasonable.

MUE values for J3465 by setting
SettingMUE (units/DOS)MAICMS rationale
Practitioner services403 Date of Service Edit: ClinicalClinical: Data
Facility outpatient hospital1203 Date of Service Edit: ClinicalClinical: Data
DME supplier03 Date of Service Edit: ClinicalCMS Policy

NCCI edits and add-on relationships

No active practitioner PTP pair lists J3465 as a column-1 or column-2 code in v323r0. Drug supply codes are rarely bundled; the administration codes billed with them are where PTP edits usually apply.

J3465 is neither an add-on code nor a designated primary code in the 2026 Q4 NCCI add-on edit file.

Medicare coverage articles

No current Billing and Coding Article lists J3465 in its HCPCS table. Coverage then follows the drug's FDA label, compendia and any National Coverage Determination; check the Medicare Coverage Database before administering off-label.

Hospital outpatient (OPPS) status

In the July 2026 OPPS Addendum B, J3465 carries status indicator N. Status N means payment is packaged into the associated procedure and no separate OPPS payment is made.

Common denials for J3465 and how to prevent them

CARC 16 · M119

NDC missing, invalid or not matched to the HCPCS code

CARC 151 · N362

units billed exceed the MUE for the date of service

CARC 50 · N115

diagnosis not covered by the applicable coverage article or LCD

How QuickIntell checks J3465 before the claim leaves

QuickCode validates the NDC-to-unit conversion against the current ASP crosswalk, checks units against every published MUE setting and flags PTP and add-on conflicts on the same claim. QuickRCM routes CARC 16, 151 and 50 denials on drug lines with the matching coverage article attached so the appeal starts with evidence.

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Frequently asked questions — HCPCS J3465

What does HCPCS code J3465 describe?

J3465 is defined by CMS as "Injection, voriconazole, 10 mg". Each billing unit represents 10 MG, so the units reported on the claim must equal the dose administered divided by that unit.

What is the Medicare reimbursement for J3465 in October 2026?

The ASP-based payment limit is $0.548 per 10 MG, with 20% beneficiary coinsurance. Medicare Administrative Contractors apply this limit; commercial payers use their own fee schedules. The July 2026 limit was $0.563.

How many units of J3465 can be billed per day?

The practitioner Medically Unlikely Edit is 40 units per date of service with adjudication indicator 3 (3 Date of Service Edit: Clinical). MAI 3 edits can be appealed with documentation that the units were medically reasonable. CMS cites "Clinical: Data" as the rationale.

Which NDCs map to J3465?

The October 2026 ASP crosswalk lists 10 NDCs from 8 labelers: Vfend Iv (Pfizer Inc); Voriconazole (Sandoz Inc.); Voriconazole (FreseniUS Kabi USA, LLC); Voriconazole (Slate Run Pharmaceuticals). For example NDC 00049-3190-01 is a 1 package equal to 20 billing units. The crosswalk's billing-units-per-package figure converts each package into J3465 units.

Does J3465 have NCCI bundling edits?

No active practitioner PTP pairs list J3465 as a column-1 or column-2 code in the v323r0 release. Unit limits (MUE) and medical-necessity coverage rules still apply.

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-01. Verify against the primary file before billing or contracting decisions.

Disclaimer

This page is an operational reference compiled from CMS publications: the Medicare Part B drug payment limit and NDC crosswalk files, NCCI MUE and add-on edit tables, aggregate PTP statistics, OPPS Addendum B and the Medicare Coverage Database. Payment limits are Medicare national amounts; commercial and Medicaid payers differ. CPT codes are shown as numbers only; CPT descriptors are copyright AMA. Nothing here is legal, clinical or billing advice.