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HCPCS J2151 · Level II · Part B drug

HCPCS J2151: Injection, mannitol, 250 mg

Reviewed by QuickIntell RCM Editorial Team · Last reviewed

Data effective
Data currency: ASP payment limits October 2026 (effective October 1, 2026); MUE and NCCI edits 2026 Q4 (effective October 1, 2026); OPPS Addendum B July 2026 (effective July 1, 2026). Next CMS release: January 1, 2027 (ASP, MUE, NCCI and OPPS quarterly updates).

Key facts for J2151

Billing unit
250 MG
Inj, mannitol, 250 mg
ASP payment limit
$0.112
October 2026; +57.8% vs July 2026
Practitioner MUE
none published
CMS publishes no MUE for this code
OPPS status
SI N
NCCI exposure
no PTP pairs
Coverage articles
0
none list this code

TL;DR

HCPCS J2151 is the Level II code for Injection, mannitol, 250 mg, billed per 250 MG. The Medicare Part B ASP payment limit for October 2026 is $0.112 per billing unit, up 57.8% from July 2026. Under OPPS it carries status indicator N. J2151 is billed in units of 250 MG; the quantity administered, the NDC package and the units on the claim must reconcile, which is the check that prevents CARC 16 and 151 returns on this line. The ASP crosswalk maps 7 NDCs to it, sold as Mannitol by Henry Schein Inc., Pfizer Inc, ICu Medical Inc.. No current Billing and Coding Article lists J2151, so coverage follows the FDA label, compendia and any applicable NCD.

Medicare Part B payment limit (ASP)

CMS sets the Part B payment limit for J2151 at $0.112 per 250 MG for October 2026, derived from manufacturer average sales price plus 6%, compared with $0.071 in July 2026. Beneficiary coinsurance is 20%.

ASP payment limits for J2151
QuarterPayment limitPerCoinsurance
October 2026$0.112250 MG20%
July 2026$0.071250 MG—
Source: CMS Medicare Part B Drug Payment Limit File. Commercial and Medicaid payers set their own rates.

NDC to HCPCS billing-unit conversion

The October 2026 ASP crosswalk maps 7 NDCs from 5 labelers to J2151. Report the NDC in the claim's drug segment and bill the number of J2151 units that equals the quantity administered divided by 250 MG; the last column gives units per full package.

NDCs that crosswalk to J2151
NDCDrug nameLabelerPackage sizeBilling units / package
00404-9905-50MannitolHenry Schein Inc.50 × 150
00409-4031-01MannitolPfizer Inc50 × 251250
00990-7715-02MannitolICu Medical Inc.250 × 244800
00990-7715-03MannitolICu Medical Inc.500 × 124800
51662-1468-01MannitolHF Acquisition Co. LLC, DBA HealthFirst50 × 150
51662-1468-03MannitolHF Acquisition Co. LLC, DBA HealthFirst50 × 251250
63323-0024-25MannitolFreseniUS Kabi USA, LLC50 × 2550

Medically Unlikely Edits (MUE)

CMS does not publish an MUE for J2151 in the 2026 Q4 tables. Some MUE values are confidential and applied without publication, so unit limits can still deny; document the dose and the units calculation on every claim.

NCCI edits and add-on relationships

No active practitioner PTP pair lists J2151 as a column-1 or column-2 code in v323r0. Drug supply codes are rarely bundled; the administration codes billed with them are where PTP edits usually apply.

J2151 is neither an add-on code nor a designated primary code in the 2026 Q4 NCCI add-on edit file.

Medicare coverage articles

No current Billing and Coding Article lists J2151 in its HCPCS table. Coverage then follows the drug's FDA label, compendia and any National Coverage Determination; check the Medicare Coverage Database before administering off-label.

Hospital outpatient (OPPS) status

In the July 2026 OPPS Addendum B, J2151 carries status indicator N. Status N means payment is packaged into the associated procedure and no separate OPPS payment is made.

Common denials for J2151 and how to prevent them

CARC 16 · M119

NDC missing, invalid or not matched to the HCPCS code

CARC 151 · N362

units billed exceed the MUE for the date of service

CARC 50 · N115

diagnosis not covered by the applicable coverage article or LCD

How QuickIntell checks J2151 before the claim leaves

QuickCode validates the NDC-to-unit conversion against the current ASP crosswalk, checks units against every published MUE setting and flags PTP and add-on conflicts on the same claim. QuickRCM routes CARC 16, 151 and 50 denials on drug lines with the matching coverage article attached so the appeal starts with evidence.

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Frequently asked questions — HCPCS J2151

What does HCPCS code J2151 describe?

J2151 is defined by CMS as "Injection, mannitol, 250 mg". Each billing unit represents 250 MG, so the units reported on the claim must equal the dose administered divided by that unit.

What is the Medicare reimbursement for J2151 in October 2026?

The ASP-based payment limit is $0.112 per 250 MG, with 20% beneficiary coinsurance. Medicare Administrative Contractors apply this limit; commercial payers use their own fee schedules. The July 2026 limit was $0.071.

Which NDCs map to J2151?

The October 2026 ASP crosswalk lists 7 NDCs from 5 labelers: Mannitol (Henry Schein Inc.); Mannitol (Pfizer Inc); Mannitol (ICu Medical Inc.); Mannitol (HF Acquisition Co. LLC, DBA HealthFirst). For example NDC 00404-9905-50 is a 50 package equal to 50 billing units. The crosswalk's billing-units-per-package figure converts each package into J2151 units.

Does J2151 have NCCI bundling edits?

No active practitioner PTP pairs list J2151 as a column-1 or column-2 code in the v323r0 release. Unit limits (MUE) and medical-necessity coverage rules still apply.

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-02. Verify against the primary file before billing or contracting decisions.

Disclaimer

This page is an operational reference compiled from CMS publications: the Medicare Part B drug payment limit and NDC crosswalk files, NCCI MUE and add-on edit tables, aggregate PTP statistics, OPPS Addendum B and the Medicare Coverage Database. Payment limits are Medicare national amounts; commercial and Medicaid payers differ. CPT codes are shown as numbers only; CPT descriptors are copyright AMA. Nothing here is legal, clinical or billing advice.