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HCPCS J1599 · Level II · J code

J1599: Injection, immune globulin, intravenous, non-lyophilized (e.g., liquid), HCPCS Level II J code

Compiled from CMS files by the QuickIntell RCM Editorial Team · Data effective · Method: reference methodology · Report a data correction

Data currency: HCPCS Level II file: October 2026 (effective October 1, 2026); PFS relative value file: RVU26D, released August 26, 2026 (effective October 1, 2026); NCCI MUE tables: 2026 Q4 (effective October 1, 2026); NCCI PTP edits: v323r0 (2026 Q4) (effective October 1, 2026); OPPS Addendum B: October 2026 (effective October 1, 2026); Medicare Coverage Database LCD export: MCD release October 8, 2026 (effective October 4, 2026). Next CMS release: January 1, 2027 (quarterly update) for the HCPCS Level II file and NCCI MUE tables and NCCI PTP edits and OPPS Addendum B; RVU27A with the CY2027 PFS final rule, effective January 1, 2027 for the PFS relative value file; weekly, every Thursday for the Medicare Coverage Database LCD export.

Key facts for J1599

Medicare payment
no PFS amount
PFS status E
Coverage code
C
carrier judgment, so the Medicare contractor decides coverage
Practitioner MUE
300
MAI 3
OPPS status
SI N
Items and Services packaged into APC rates
NCCI PTP pairs
0
practitioner file
LCDs and articles
6 / 5

TL;DR

CMS describes HCPCS J1599, added in 2011, as "Injection, immune globulin, intravenous, non-lyophilized (e.g., liquid), not otherwise specified, 500 mg". The physician fee schedule lists J1599 with status E (excluded from the physician fee schedule by regulation), so the PFS carries no national amount for it. MUE limits for J1599: practitioner 300 (MAI 3, Clinical: Data); hospital outpatient 300 (MAI 3, Clinical: Data); DME supplier 300 (MAI 3, Clinical: Data). 6 active LCDs and 5 billing and coding articles list J1599 across 21 states: L33610 (Intravenous Immune Globulin), L34314 (Immune Globulin Intravenous (IVIg)), A56718, A57160. OPPS status indicator N: Items and Services packaged into APC rates. HCPCS record: BETOS O1E (other drugs); pricing indicator 51; type of service 1 (medical care), P (lump-sum purchase of DME, prosthetics or orthotics). 149 other active codes open with "Injection"; related codes: J1815, J2003, J2004, J1050.

J1599 descriptor and code status

The October 2026 HCPCS Level II file describes J1599 as “Injection, immune globulin, intravenous, non-lyophilized (e.g., liquid), not otherwise specified, 500 mg”. It sits in the J section (drugs administered other than oral method and chemotherapy drugs), listed with the other J codes without an ASP payment limit.

HCPCS file attributes of J1599
FieldValue
Short descriptorIvig non-lyophilized, nos
Added to HCPCS2011-01-01
Last actionN (no maintenance), effective 2011-01-01
Coverage codeC: carrier judgment, so the Medicare contractor decides coverage
Pricing indicator51: drugs
BETOS categoryO1E: other drugs
Type of service1: medical care; P: lump-sum purchase of DME, prosthetics or orthotics

Medicare payment for J1599

The physician fee schedule lists J1599 with status E (excluded from the physician fee schedule by regulation), so the PFS carries no national amount for it. The amounts below are national figures from the October 2026 CMS files; the contractor applies the locality, rural or state adjustment and the beneficiary's cost sharing.

Physician fee schedule (RVU26D)

Status E: excluded from the physician fee schedule by regulation. Global period XXX (global surgery concept does not apply); PC/TC indicator 9 (professional/technical concept does not apply).

Hospital outpatient (OPPS Addendum B)

Status indicator N (Items and Services packaged into APC rates), with no separate OPPS payment rate.

Ambulatory surgical center (Addendum BB)

Payment indicator N1 (Packaged service/item; no separate payment made).

Medically Unlikely Edits for J1599

MUE limits for J1599: practitioner 300 (MAI 3, Clinical: Data); hospital outpatient 300 (MAI 3, Clinical: Data); DME supplier 300 (MAI 3, Clinical: Data). The practitioner MUE is a date-of-service clinical edit: units above the limit deny but can be paid on appeal with documentation.

MUE values for J1599 by setting
SettingMUE (units/DOS)MAICMS rationale
Practitioner services3003 Date of Service Edit: ClinicalClinical: Data
Facility outpatient hospital3003 Date of Service Edit: ClinicalClinical: Data
DME supplier3003 Date of Service Edit: ClinicalClinical: Data

The MUE lookup for J1599 shows every setting next to any other code on the same claim.

NCCI edits and add-on rules

No active practitioner PTP pair lists J1599 in v323r0.

J1599 is neither an add-on code nor a designated primary code in the 2026 Q4 NCCI add-on edit file.

Pair counts show exposure, not the answer for one claim. Check J1599 against a second code to see whether the pair bundles and whether a modifier can separate the services.

Medicare coverage policies for J1599

6 active Local Coverage Determinations and 5 billing and coding articles list J1599. Each applies only in its contractor's jurisdiction, and the article carries the diagnosis codes that support the item or service.

Billing and Coding Articles listing J1599
ArticleTitleContractor(s)Related LCD
A56718Billing and Coding: Intravenous Immunoglobulin (IVIG)Palmetto GBAL34580
A57160Billing and Coding: Immune Thrombocytopenia (ITP) TherapyCGS Administrators, LLCL38268
A57187Billing and Coding: Immune Globulin Intravenous (IVIg)Noridian Healthcare Solutions, LLCL34314
A57554Billing and Coding: Immune GlobulinsWisconsin Physicians Service Insurance CorporationL34771
A59105Billing and Coding: Off-Label Use of Intravenous Immune Globulin (IVIG)Wellpoint FederalL39314

Denials to expect on J1599

CARC 50 · N115

the diagnosis or documentation does not meet the LCD or billing article that lists J1599

CARC 151 · N362

units of J1599 exceed the practitioner MUE of 300 per date of service

CARC 4

the modifier reported is inconsistent with the code

CARC 16

the claim lacks the description, invoice or pricing detail a contractor-priced code needs

Where QuickIntell fits for J1599 claims

QuickCode supports qualified coder review of units, modifiers and NCCI pairs for J1599 before the claim leaves, and QuickRCM carries claim readiness and the denial follow-up when an edit or coverage policy is missed.

See QuickCode for coder reviewSee QuickRCM for denial follow-upBook a meeting

Frequently asked questions: HCPCS J1599

What does HCPCS code J1599 describe?

"Injection, immune globulin, intravenous, non-lyophilized (e.g., liquid), not otherwise specified, 500 mg" (short descriptor "Ivig non-lyophilized, nos"), in the J section (drugs administered other than oral method and chemotherapy drugs). Added 2011-01-01.

Is J1599 a CPT code?

No: CMS maintains J1599 in HCPCS Level II, while the AMA maintains CPT. It goes in the same procedure-code field.

What does Medicare pay for J1599?

The physician fee schedule lists J1599 with status E (excluded from the physician fee schedule by regulation), so the PFS carries no national amount for it.

How many units of J1599 can be billed per day?

MUE limits for J1599: practitioner 300 (MAI 3, Clinical: Data); hospital outpatient 300 (MAI 3, Clinical: Data); DME supplier 300 (MAI 3, Clinical: Data). For the practitioner MUE (MAI 3), units above 300 deny for the day but can be paid on appeal with documentation; denials arrive as CARC 151.

Does Medicare cover J1599?

Coverage code C (carrier judgment, so the Medicare contractor decides coverage). 6 active LCDs and 5 billing and coding articles list J1599 across 21 states: L33610 (Intravenous Immune Globulin), L34314 (Immune Globulin Intravenous (IVIg)), A56718, A57160.

CMS guidance

The Medicare Learning Network publication that CMS issues on this topic, cited by ICN and publication date:

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-10. Verify against the primary file before billing or contracting decisions. The reference methodology explains how each figure is computed from these files.

Disclaimer

This page is an operational reference compiled from CMS publications: the HCPCS Level II file, the physician, DMEPOS and clinical laboratory fee schedules, OPPS and ASC addenda, NCCI MUE, PTP and add-on edit tables and the Medicare Coverage Database. Amounts are Medicare national figures before locality and state adjustment; Medicaid and commercial payers set their own. CPT codes are shown as numbers only; CPT descriptors are copyright AMA. Nothing here is legal, clinical or billing advice.

Found a figure that does not match the CMS file? Report a data correction with the CMS file and the value you expected; the request reaches the editorial team through the contact form.