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HCPCS J1557 · Level II · Part B drug

HCPCS J1557: Injection, immune globulin, (gammaplex), intravenous, non-lyophilized (e.g.,

Reviewed by QuickIntell RCM Editorial Team · Last reviewed

Data effective
Data currency: ASP payment limits October 2026 (effective October 1, 2026); MUE and NCCI edits 2026 Q4 (effective October 1, 2026); OPPS Addendum B July 2026 (effective July 1, 2026). Next CMS release: January 1, 2027 (ASP, MUE, NCCI and OPPS quarterly updates).

Key facts for J1557

Billing unit
500 MG
Gammaplex injection
ASP payment limit
$62.299
October 2026; -6.0% vs July 2026
Practitioner MUE
300
MAI 3
OPPS status
SI K
APC 9270
NCCI exposure
no PTP pairs
Coverage articles
1
4 states

TL;DR

HCPCS J1557 is the Level II code for Injection, immune globulin, (gammaplex), intravenous, non-lyophilized (e.g.,, billed per 500 MG. The Medicare Part B ASP payment limit for October 2026 is $62.299 per billing unit, down 6.0% from July 2026. The practitioner MUE allows up to 300 units per date of service (MAI 3). Under OPPS it carries status indicator K in APC 9270. J1557 is billed in units of 500 MG; the quantity administered, the NDC package and the units on the claim must reconcile, which is the check that prevents CARC 16 and 151 returns on this line. The ASP crosswalk maps 6 NDCs to it, sold as Gammaplex by Bio Products Laboratory. 1 Medicare coverage article lists the code across 4 states, including .

Medicare Part B payment limit (ASP)

CMS sets the Part B payment limit for J1557 at $62.299 per 500 MG for October 2026, derived from manufacturer average sales price plus 6%, compared with $66.272 in July 2026. Beneficiary coinsurance is 20%.

ASP payment limits for J1557
QuarterPayment limitPerCoinsurance
October 2026$62.299500 MG20%
July 2026$66.272500 MG—
Source: CMS Medicare Part B Drug Payment Limit File. Commercial and Medicaid payers set their own rates.

NDC to HCPCS billing-unit conversion

The October 2026 ASP crosswalk maps 6 NDCs from 1 labeler to J1557. Report the NDC in the claim's drug segment and bill the number of J1557 units that equals the quantity administered divided by 500 MG; the last column gives units per full package.

NDCs that crosswalk to J1557
NDCDrug nameLabelerPackage sizeBilling units / package
64208-8234-06GammaplexBio Products Laboratory100 × 110
64208-8234-07GammaplexBio Products Laboratory200 × 120
64208-8234-08GammaplexBio Products Laboratory100 × 140
64208-8235-05GammaplexBio Products Laboratory50 × 110
64208-8235-06GammaplexBio Products Laboratory100 × 120
64208-8235-07GammaplexBio Products Laboratory200 × 140

Medically Unlikely Edits (MUE)

CMS publishes 3 MUE values for J1557. For practitioners the limit is 300 units per date of service with adjudication indicator 3, a date-of-service clinical edit: units above the limit deny but can be paid on appeal with documentation that the quantity was medically reasonable.

MUE values for J1557 by setting
SettingMUE (units/DOS)MAICMS rationale
Practitioner services3003 Date of Service Edit: ClinicalClinical: Data
Facility outpatient hospital3003 Date of Service Edit: ClinicalClinical: Data
DME supplier3003 Date of Service Edit: ClinicalClinical: Data

NCCI edits and add-on relationships

No active practitioner PTP pair lists J1557 as a column-1 or column-2 code in v323r0. Drug supply codes are rarely bundled; the administration codes billed with them are where PTP edits usually apply.

J1557 is neither an add-on code nor a designated primary code in the 2026 Q4 NCCI add-on edit file.

Medicare coverage articles

1 current Medicare Administrative Contractor article lists J1557 in their HCPCS tables, covering 4 states. Each article carries the covered and non-covered ICD-10 codes that medical-necessity denials (CARC 50) are adjudicated against.

Billing and Coding Articles listing J1557
ArticleTitleContractor(s)StatesRelated LCD
Billing and Coding: Intravenous Immunoglobulin (IVIG)Palmetto GBANC SC VA WVL34580

Hospital outpatient (OPPS) status

In the July 2026 OPPS Addendum B, J1557 carries status indicator K and is assigned to APC 9270, with a published national unadjusted payment of $66.27. Status K means the drug is paid separately under OPPS at the ASP-based rate rather than packaged into the procedure.

Common denials for J1557 and how to prevent them

CARC 16 · M119

NDC missing, invalid or not matched to the HCPCS code

CARC 151 · N362

units billed exceed the MUE for the date of service

CARC 50 · N115

diagnosis not covered by the applicable coverage article or LCD

How QuickIntell checks J1557 before the claim leaves

QuickCode validates the NDC-to-unit conversion against the current ASP crosswalk, checks units against every published MUE setting and flags PTP and add-on conflicts on the same claim. QuickRCM routes CARC 16, 151 and 50 denials on drug lines with the matching coverage article attached so the appeal starts with evidence.

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Frequently asked questions — HCPCS J1557

What does HCPCS code J1557 describe?

J1557 is defined by CMS as "Injection, immune globulin, (gammaplex), intravenous, non-lyophilized (e.g.,". Each billing unit represents 500 MG, so the units reported on the claim must equal the dose administered divided by that unit.

What is the Medicare reimbursement for J1557 in October 2026?

The ASP-based payment limit is $62.299 per 500 MG, with 20% beneficiary coinsurance. Medicare Administrative Contractors apply this limit; commercial payers use their own fee schedules. The July 2026 limit was $66.272.

How many units of J1557 can be billed per day?

The practitioner Medically Unlikely Edit is 300 units per date of service with adjudication indicator 3 (3 Date of Service Edit: Clinical). MAI 3 edits can be appealed with documentation that the units were medically reasonable. CMS cites "Clinical: Data" as the rationale.

Which NDCs map to J1557?

The October 2026 ASP crosswalk lists 6 NDCs from 1 labeler: Gammaplex (Bio Products Laboratory). For example NDC 64208-8234-06 is a 100 package equal to 10 billing units. The crosswalk's billing-units-per-package figure converts each package into J1557 units.

Does J1557 have NCCI bundling edits?

No active practitioner PTP pairs list J1557 as a column-1 or column-2 code in the v323r0 release. Unit limits (MUE) and medical-necessity coverage rules still apply.

Which Medicare coverage articles mention J1557?

1 current Billing and Coding Article in the Medicare Coverage Database list J1557, covering 4 states: (Billing and Coding: Intravenous Immunoglobulin (IVIG)).

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-01. Verify against the primary file before billing or contracting decisions.

Disclaimer

This page is an operational reference compiled from CMS publications: the Medicare Part B drug payment limit and NDC crosswalk files, NCCI MUE and add-on edit tables, aggregate PTP statistics, OPPS Addendum B and the Medicare Coverage Database. Payment limits are Medicare national amounts; commercial and Medicaid payers differ. CPT codes are shown as numbers only; CPT descriptors are copyright AMA. Nothing here is legal, clinical or billing advice.