Skip to main content
HCPCS J0740 · Level II · Part B drug

HCPCS J0740: Injection, cidofovir, 375 mg

Reviewed by QuickIntell RCM Editorial Team · Last reviewed

Data effective
Data currency: ASP payment limits October 2026 (effective October 1, 2026); MUE and NCCI edits 2026 Q4 (effective October 1, 2026); OPPS Addendum B July 2026 (effective July 1, 2026). Next CMS release: January 1, 2027 (ASP, MUE, NCCI and OPPS quarterly updates).

Key facts for J0740

Billing unit
375 MG
Cidofovir injection
ASP payment limit
$522.238
October 2026; -2.5% vs July 2026
Practitioner MUE
2
MAI 3
OPPS status
SI K
APC 9033
NCCI exposure
no PTP pairs
Coverage articles
0
none list this code

TL;DR

HCPCS J0740 is the Level II code for Injection, cidofovir, 375 mg, billed per 375 MG. The Medicare Part B ASP payment limit for October 2026 is $522.238 per billing unit, down 2.5% from July 2026. The practitioner MUE allows up to 2 units per date of service (MAI 3). Under OPPS it carries status indicator K in APC 9033. J0740 is billed in units of 375 MG; the quantity administered, the NDC package and the units on the claim must reconcile, which is the check that prevents CARC 16 and 151 returns on this line. The ASP crosswalk maps 2 NDCs to it, sold as Cidofovir by Heritage Pharmaceuticals Inc., Mylan Institutional LLC. No current Billing and Coding Article lists J0740, so coverage follows the FDA label, compendia and any applicable NCD.

Medicare Part B payment limit (ASP)

CMS sets the Part B payment limit for J0740 at $522.238 per 375 MG for October 2026, derived from manufacturer average sales price plus 6%, compared with $535.735 in July 2026. Beneficiary coinsurance is 20%.

ASP payment limits for J0740
QuarterPayment limitPerCoinsurance
October 2026$522.238375 MG20%
July 2026$535.735375 MG—
Source: CMS Medicare Part B Drug Payment Limit File. Commercial and Medicaid payers set their own rates.

NDC to HCPCS billing-unit conversion

The October 2026 ASP crosswalk maps 2 NDCs from 2 labelers to J0740. Report the NDC in the claim's drug segment and bill the number of J0740 units that equals the quantity administered divided by 375 MG; the last column gives units per full package.

NDCs that crosswalk to J0740
NDCDrug nameLabelerPackage sizeBilling units / package
23155-0216-31CidofovirHeritage Pharmaceuticals Inc.5 × 11
67457-0210-05CidofovirMylan Institutional LLC5 × 11

Medically Unlikely Edits (MUE)

CMS publishes 3 MUE values for J0740. For practitioners the limit is 2 units per date of service with adjudication indicator 3, a date-of-service clinical edit: units above the limit deny but can be paid on appeal with documentation that the quantity was medically reasonable.

MUE values for J0740 by setting
SettingMUE (units/DOS)MAICMS rationale
Practitioner services23 Date of Service Edit: ClinicalPrescribing Information
Facility outpatient hospital23 Date of Service Edit: ClinicalPrescribing Information
DME supplier03 Date of Service Edit: ClinicalCMS Policy

NCCI edits and add-on relationships

No active practitioner PTP pair lists J0740 as a column-1 or column-2 code in v323r0. Drug supply codes are rarely bundled; the administration codes billed with them are where PTP edits usually apply.

J0740 is neither an add-on code nor a designated primary code in the 2026 Q4 NCCI add-on edit file.

Medicare coverage articles

No current Billing and Coding Article lists J0740 in its HCPCS table. Coverage then follows the drug's FDA label, compendia and any National Coverage Determination; check the Medicare Coverage Database before administering off-label.

Hospital outpatient (OPPS) status

In the July 2026 OPPS Addendum B, J0740 carries status indicator K and is assigned to APC 9033, with a published national unadjusted payment of $535.74. Status K means the drug is paid separately under OPPS at the ASP-based rate rather than packaged into the procedure.

Common denials for J0740 and how to prevent them

CARC 16 · M119

NDC missing, invalid or not matched to the HCPCS code

CARC 151 · N362

units billed exceed the MUE for the date of service

CARC 50 · N115

diagnosis not covered by the applicable coverage article or LCD

How QuickIntell checks J0740 before the claim leaves

QuickCode validates the NDC-to-unit conversion against the current ASP crosswalk, checks units against every published MUE setting and flags PTP and add-on conflicts on the same claim. QuickRCM routes CARC 16, 151 and 50 denials on drug lines with the matching coverage article attached so the appeal starts with evidence.

Explore QuickCodeExplore QuickRCMBook a demo

Frequently asked questions — HCPCS J0740

What does HCPCS code J0740 describe?

J0740 is defined by CMS as "Injection, cidofovir, 375 mg". Each billing unit represents 375 MG, so the units reported on the claim must equal the dose administered divided by that unit.

What is the Medicare reimbursement for J0740 in October 2026?

The ASP-based payment limit is $522.238 per 375 MG, with 20% beneficiary coinsurance. Medicare Administrative Contractors apply this limit; commercial payers use their own fee schedules. The July 2026 limit was $535.735.

How many units of J0740 can be billed per day?

The practitioner Medically Unlikely Edit is 2 units per date of service with adjudication indicator 3 (3 Date of Service Edit: Clinical). MAI 3 edits can be appealed with documentation that the units were medically reasonable. CMS cites "Prescribing Information" as the rationale.

Which NDCs map to J0740?

The October 2026 ASP crosswalk lists 2 NDCs from 2 labelers: Cidofovir (Heritage Pharmaceuticals Inc.); Cidofovir (Mylan Institutional LLC). For example NDC 23155-0216-31 is a 5 package equal to 1 billing unit. The crosswalk's billing-units-per-package figure converts each package into J0740 units.

Does J0740 have NCCI bundling edits?

No active practitioner PTP pairs list J0740 as a column-1 or column-2 code in the v323r0 release. Unit limits (MUE) and medical-necessity coverage rules still apply.

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-01. Verify against the primary file before billing or contracting decisions.

Disclaimer

This page is an operational reference compiled from CMS publications: the Medicare Part B drug payment limit and NDC crosswalk files, NCCI MUE and add-on edit tables, aggregate PTP statistics, OPPS Addendum B and the Medicare Coverage Database. Payment limits are Medicare national amounts; commercial and Medicaid payers differ. CPT codes are shown as numbers only; CPT descriptors are copyright AMA. Nothing here is legal, clinical or billing advice.