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HCPCS J0665 · Level II · Part B drug

HCPCS J0665: Injection, bupivicaine, not otherwise specified, 0.5 mg

Reviewed by QuickIntell RCM Editorial Team · Last reviewed

Data effective
Data currency: ASP payment limits October 2026 (effective October 1, 2026); MUE and NCCI edits 2026 Q4 (effective October 1, 2026); OPPS Addendum B July 2026 (effective July 1, 2026). Next CMS release: January 1, 2027 (ASP, MUE, NCCI and OPPS quarterly updates).

Key facts for J0665

Billing unit
0.5 MG
Inj, bupivacaine, nos, 0.5mg
ASP payment limit
$0.01
October 2026; -9.1% vs July 2026
Practitioner MUE
none published
CMS publishes no MUE for this code
OPPS status
SI N
NCCI exposure
no PTP pairs
Coverage articles
0
none list this code

TL;DR

HCPCS J0665 is the Level II code for Injection, bupivicaine, not otherwise specified, 0.5 mg, billed per 0.5 MG. The Medicare Part B ASP payment limit for October 2026 is $0.01 per billing unit, down 9.1% from July 2026. Under OPPS it carries status indicator N. J0665 is billed in units of 0.5 MG; the quantity administered, the NDC package and the units on the claim must reconcile, which is the check that prevents CARC 16 and 151 returns on this line. The ASP crosswalk maps 99 NDCs to it, sold as Bupivacaine HCl, Marcaine, Sensorcaine by Hikma Pharmaceuticals USA Inc., Henry Schein Inc., Pfizer Inc. No current Billing and Coding Article lists J0665, so coverage follows the FDA label, compendia and any applicable NCD.

Medicare Part B payment limit (ASP)

CMS sets the Part B payment limit for J0665 at $0.01 per 0.5 MG for October 2026, derived from manufacturer average sales price plus 6%, compared with $0.011 in July 2026. Beneficiary coinsurance is 20%.

ASP payment limits for J0665
QuarterPayment limitPerCoinsurance
October 2026$0.010.5 MG20%
July 2026$0.0110.5 MG—
Source: CMS Medicare Part B Drug Payment Limit File. Commercial and Medicaid payers set their own rates.

NDC to HCPCS billing-unit conversion

The October 2026 ASP crosswalk maps 99 NDCs from 13 labelers to J0665. Report the NDC in the claim's drug segment and bill the number of J0665 units that equals the quantity administered divided by 0.5 MG; the last column gives units per full package.

NDCs that crosswalk to J0665
NDCDrug nameLabelerPackage sizeBilling units / package
00143-9328-10Bupivacaine HClHikma Pharmaceuticals USA Inc.50 × 102500
00143-9329-10Bupivacaine HClHikma Pharmaceuticals USA Inc.50 × 105000
00143-9330-10Bupivacaine HClHikma Pharmaceuticals USA Inc.10 × 10500
00143-9331-10Bupivacaine HClHikma Pharmaceuticals USA Inc.10 × 101000
00143-9332-10Bupivacaine HClHikma Pharmaceuticals USA Inc.10 × 101500
00143-9333-10Bupivacaine HClHikma Pharmaceuticals USA Inc.30 × 101500
00143-9334-10Bupivacaine HClHikma Pharmaceuticals USA Inc.30 × 103000
00143-9335-10Bupivacaine HClHikma Pharmaceuticals USA Inc.30 × 104500
00404-9768-30MarcaineHenry Schein Inc.30 × 1300
00404-9770-10MarcaineHenry Schein Inc.10 × 150
00404-9826-50Bupivacaine HClHenry Schein Inc.50 × 1250
00404-9827-50Bupivacaine HClHenry Schein Inc.50 × 1500
00404-9906-10MarcaineHenry Schein Inc.10 × 150
00404-9907-10MarcaineHenry Schein Inc.10 × 1100
00404-9907-30MarcaineHenry Schein Inc.30 × 1300
00404-9945-50SensorcaineHenry Schein Inc.50 × 1250
00404-9946-10SensorcaineHenry Schein Inc.10 × 1100
00404-9947-50SensorcaineHenry Schein Inc.50 × 1500
00409-0525-25MarcainePfizer Inc50 × 2512500
00409-1159-01Bupivacaine HClPfizer Inc10 × 251250
00409-1159-02Bupivacaine HClPfizer Inc30 × 253750
00409-1159-10Bupivacaine HClPfizer Inc30 × 253750
00409-1160-01Bupivacaine HClPfizer Inc50 × 256250
00409-1162-01Bupivacaine HClPfizer Inc10 × 252500
00409-1162-02Bupivacaine HClPfizer Inc30 × 257500
00409-1163-01Bupivacaine HClPfizer Inc50 × 2512500
00409-1165-01Bupivacaine HClPfizer Inc10 × 253750
00409-1165-02Bupivacaine HClPfizer Inc30 × 2511250
00409-1530-25MarcainePfizer Inc30 × 257500
00409-1559-10MarcainePfizer Inc10 × 10500
00409-1559-30MarcainePfizer Inc30 × 101500
00409-1560-10MarcainePfizer Inc10 × 101000
00409-1560-29MarcainePfizer Inc30 × 103000
00409-1582-10MarcainePfizer Inc10 × 101500
00409-1582-29MarcainePfizer Inc30 × 104500
00409-1587-50MarcainePfizer Inc50 × 1250
00409-1610-50MarcainePfizer Inc50 × 1500
00409-1761-10Marcaine SpinalPfizer Inc2 × 10300
00409-1761-62Marcaine SpinalPfizer Inc2 × 80024000
00409-2253-25MarcainePfizer Inc30 × 2511250
00409-2510-25MarcainePfizer Inc10 × 251250
00409-5010-25MarcainePfizer Inc10 × 252500
00409-7535-25MarcainePfizer Inc30 × 253750
50090-4516-00Bupivacaine HClA-S Medication Solutions50 × 1500
51662-1396-01Bupivacaine HClHF Acquisition Co. LLC, DBA HealthFirst50 × 1500
51662-1396-03Bupivacaine HClHF Acquisition Co. LLC, DBA HealthFirst50 × 2512500
51662-1581-03Bupivacaine HClHF Acquisition Co. LLC, DBA HealthFirst50 × 256250
51662-1588-03SensorcaineHF Acquisition Co. LLC, DBA HealthFirst50 × 2512500
51662-1592-03SensorcaineHF Acquisition Co. LLC, DBA HealthFirst50 × 256250
52584-0465-57Bupivacaine HClHenry Schein Inc.50 × 1250
52584-0467-57Bupivacaine HClHenry Schein Inc.50 × 1500
55150-0167-10Bupivacaine HClEugia US LLC10 × 251250
55150-0168-30Bupivacaine HClEugia US LLC30 × 253750
55150-0169-10Bupivacaine HClEugia US LLC10 × 252500
55150-0170-30Bupivacaine HClEugia US LLC30 × 257500
55150-0171-10Bupivacaine HClEugia US LLC10 × 253750
55150-0172-30Bupivacaine HClEugia US LLC30 × 2511250
55150-0249-50Bupivacaine HClEugia US LLC50 × 256250
55150-0250-50Bupivacaine HClEugia US LLC50 × 2512500
63323-0464-17Sensorcaine-MPFFreseniUS Kabi USA, LLC10 × 251250
Showing 60 of 99 NDCs.

Medically Unlikely Edits (MUE)

CMS does not publish an MUE for J0665 in the 2026 Q4 tables. Some MUE values are confidential and applied without publication, so unit limits can still deny; document the dose and the units calculation on every claim.

NCCI edits and add-on relationships

No active practitioner PTP pair lists J0665 as a column-1 or column-2 code in v323r0. Drug supply codes are rarely bundled; the administration codes billed with them are where PTP edits usually apply.

J0665 is neither an add-on code nor a designated primary code in the 2026 Q4 NCCI add-on edit file.

Medicare coverage articles

No current Billing and Coding Article lists J0665 in its HCPCS table. Coverage then follows the drug's FDA label, compendia and any National Coverage Determination; check the Medicare Coverage Database before administering off-label.

Hospital outpatient (OPPS) status

In the July 2026 OPPS Addendum B, J0665 carries status indicator N. Status N means payment is packaged into the associated procedure and no separate OPPS payment is made.

Common denials for J0665 and how to prevent them

CARC 16 · M119

NDC missing, invalid or not matched to the HCPCS code

CARC 151 · N362

units billed exceed the MUE for the date of service

CARC 50 · N115

diagnosis not covered by the applicable coverage article or LCD

How QuickIntell checks J0665 before the claim leaves

QuickCode validates the NDC-to-unit conversion against the current ASP crosswalk, checks units against every published MUE setting and flags PTP and add-on conflicts on the same claim. QuickRCM routes CARC 16, 151 and 50 denials on drug lines with the matching coverage article attached so the appeal starts with evidence.

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Frequently asked questions — HCPCS J0665

What does HCPCS code J0665 describe?

J0665 is defined by CMS as "Injection, bupivicaine, not otherwise specified, 0.5 mg". Each billing unit represents 0.5 MG, so the units reported on the claim must equal the dose administered divided by that unit.

What is the Medicare reimbursement for J0665 in October 2026?

The ASP-based payment limit is $0.01 per 0.5 MG, with 20% beneficiary coinsurance. Medicare Administrative Contractors apply this limit; commercial payers use their own fee schedules. The July 2026 limit was $0.011.

Which NDCs map to J0665?

The October 2026 ASP crosswalk lists 99 NDCs from 13 labelers: Bupivacaine HCl (Hikma Pharmaceuticals USA Inc.); Marcaine (Henry Schein Inc.); Bupivacaine HCl (Henry Schein Inc.); Sensorcaine (Henry Schein Inc.). For example NDC 00143-9328-10 is a 50 package equal to 2500 billing units. The crosswalk's billing-units-per-package figure converts each package into J0665 units.

Does J0665 have NCCI bundling edits?

No active practitioner PTP pairs list J0665 as a column-1 or column-2 code in the v323r0 release. Unit limits (MUE) and medical-necessity coverage rules still apply.

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-02. Verify against the primary file before billing or contracting decisions.

Disclaimer

This page is an operational reference compiled from CMS publications: the Medicare Part B drug payment limit and NDC crosswalk files, NCCI MUE and add-on edit tables, aggregate PTP statistics, OPPS Addendum B and the Medicare Coverage Database. Payment limits are Medicare national amounts; commercial and Medicaid payers differ. CPT codes are shown as numbers only; CPT descriptors are copyright AMA. Nothing here is legal, clinical or billing advice.