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HCPCS G0476 · Level II · G code

G0476: Infectious agent detection by nucleic acid (DNA or RNA); human papillomavirus (HPV), HCPCS Level II G code

Compiled from CMS files by the QuickIntell RCM Editorial Team · Data effective · Method: reference methodology · Report a data correction

Data currency: HCPCS Level II file: October 2026 (effective October 1, 2026); PFS relative value file: RVU26D, released August 26, 2026 (effective October 1, 2026); Clinical Laboratory Fee Schedule: 26CLABQ4 (CY2026 Q4) (effective October 1, 2026); NCCI MUE tables: 2026 Q4 (effective October 1, 2026); NCCI PTP edits: v323r0 (2026 Q4) (effective October 1, 2026); OPPS Addendum B: October 2026 (effective October 1, 2026). Next CMS release: January 1, 2027 (quarterly update) for the HCPCS Level II file and Clinical Laboratory Fee Schedule and NCCI MUE tables and NCCI PTP edits and OPPS Addendum B; RVU27A with the CY2027 PFS final rule, effective January 1, 2027 for the PFS relative value file.

Key facts for G0476

Medicare payment
$35.09
CLFS national limitation amount
Coverage code
C
carrier judgment, so the Medicare contractor decides coverage
Practitioner MUE
1
MAI 2
OPPS status
SI A
Services not paid under OPPS; paid under fee schedule or other payment system
NCCI PTP pairs
302
302 hospital outpatient
LCDs and articles
0 / 0

TL;DR

CMS describes HCPCS G0476, added in 2015, as "Infectious agent detection by nucleic acid (dna or rna); human papillomavirus (hpv), high-risk types (e.g., 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68) for cervical cancer screening, must be performed in addition to pap test". The 2026 Q4 clinical laboratory fee schedule pays G0476 $35.09 (national limitation amount). Its 2026 Q4 MUEs per date of service: practitioner 1 (MAI 2, CMS Policy); hospital outpatient 1 (MAI 2, CMS Policy). In the NCCI PTP files v323r0 G0476 appears in 281 practitioner pairs as column 2 and 21 as column 1 (most often with 0008U, 0010U, 0016U), and in 281 hospital outpatient pairs as column 2 and 21 as column 1. No current LCD or billing article lists G0476; its HCPCS coverage code is C (carrier judgment, so the Medicare contractor decides coverage). OPPS status indicator A: Services not paid under OPPS; paid under fee schedule or other payment system. HCPCS record: BETOS T2D (other tests - other); pricing indicator 13; type of service 5 (diagnostic laboratory). 1 other active code opens with "Infectious agent detection by nucleic acid"; related codes: G0567, G0475, G0473, G0472.

G0476 descriptor and code status

The October 2026 HCPCS Level II file describes G0476 as “Infectious agent detection by nucleic acid (dna or rna); human papillomavirus (hpv), high-risk types (e.g., 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68) for cervical cancer screening, must be performed in addition to pap test”. It sits in the G section (procedures and professional services, temporary), listed with the other G codes. Although searches often call it the "G0476 CPT code", G0476 is a HCPCS Level II code maintained by CMS, not an AMA CPT code; both go in the same procedure-code field on the claim.

HCPCS file attributes of G0476
FieldValue
Short descriptorHpv combo assay ca screen
Added to HCPCS2015-07-09
Last actionN (no maintenance), effective 2015-07-09
Coverage codeC: carrier judgment, so the Medicare contractor decides coverage
Pricing indicator13: physician fee schedule, priced by the contractor
BETOS categoryT2D: other tests - other
Type of service5: diagnostic laboratory

Medicare payment for G0476

The 2026 Q4 clinical laboratory fee schedule pays G0476 $35.09 (national limitation amount). The amounts below are national figures from the October 2026 CMS files; the contractor applies the locality, rural or state adjustment and the beneficiary's cost sharing.

Physician fee schedule (RVU26D)

Status X: statutory exclusion: not a physician service under the fee schedule. Global period XXX (global surgery concept does not apply); PC/TC indicator 9 (professional/technical concept does not apply).

Clinical Laboratory Fee Schedule (26CLABQ4)

G0476 is paid at $35.09 (national limitation amount). Laboratory fee schedule payments carry no beneficiary coinsurance or deductible.

Hospital outpatient (OPPS Addendum B)

Status indicator A (Services not paid under OPPS; paid under fee schedule or other payment system), with no separate OPPS payment rate.

Medically Unlikely Edits for G0476

Its 2026 Q4 MUEs per date of service: practitioner 1 (MAI 2, CMS Policy); hospital outpatient 1 (MAI 2, CMS Policy). The practitioner MUE is a date-of-service policy edit: units above the limit deny even when split across lines, and appeals rarely succeed.

MUE values for G0476 by setting
SettingMUE (units/DOS)MAICMS rationale
Practitioner services12 Date of Service Edit: PolicyCMS Policy
Facility outpatient hospital12 Date of Service Edit: PolicyCMS Policy

The MUE lookup for G0476 shows every setting next to any other code on the same claim.

NCCI edits and add-on rules

In the practitioner PTP file v323r0, G0476 is the column-2 (bundled) code in 281 active pairs, 99% of which allow a modifier and the column-1 code in 21 (95% modifier-allowed); 16 earlier pairs have been deleted. CMS's most frequent rationale for the bundled pairs: CPT Manual or CMS manual coding instruction.

Column-1 codes most often paired with G0476 (practitioner)
Column-1 codePairs
0008U (CPT; descriptor licensed by AMA)1
0010U (CPT; descriptor licensed by AMA)1
0016U (CPT; descriptor licensed by AMA)1
0017U (CPT; descriptor licensed by AMA)1
0027U (CPT; descriptor licensed by AMA)1
0030U (CPT; descriptor licensed by AMA)1
0034U (CPT; descriptor licensed by AMA)1
0040U (CPT; descriptor licensed by AMA)1
Column-2 codes bundled into G0476 (practitioner)
Column-2 codePairs
0112U (CPT; descriptor licensed by AMA)1
0429U (CPT; descriptor licensed by AMA)1
80503 (CPT; descriptor licensed by AMA)1
80504 (CPT; descriptor licensed by AMA)1
80505 (CPT; descriptor licensed by AMA)1
80506 (CPT; descriptor licensed by AMA)1
81400 (CPT; descriptor licensed by AMA)1
81401 (CPT; descriptor licensed by AMA)1

In the hospital outpatient PTP file v323r0, G0476 is the column-2 (bundled) code in 281 active pairs, 99% of which allow a modifier and the column-1 code in 21 (95% modifier-allowed); 16 earlier pairs have been deleted. CMS's most frequent rationale for the bundled pairs: CPT Manual or CMS manual coding instruction.

Column-1 codes most often paired with G0476 (hospital outpatient)
Column-1 codePairs
0008U (CPT; descriptor licensed by AMA)1
0010U (CPT; descriptor licensed by AMA)1
0016U (CPT; descriptor licensed by AMA)1
0017U (CPT; descriptor licensed by AMA)1
0027U (CPT; descriptor licensed by AMA)1
0030U (CPT; descriptor licensed by AMA)1
0034U (CPT; descriptor licensed by AMA)1
0040U (CPT; descriptor licensed by AMA)1
Column-2 codes bundled into G0476 (hospital outpatient)
Column-2 codePairs
0112U (CPT; descriptor licensed by AMA)1
0429U (CPT; descriptor licensed by AMA)1
80503 (CPT; descriptor licensed by AMA)1
80504 (CPT; descriptor licensed by AMA)1
80505 (CPT; descriptor licensed by AMA)1
80506 (CPT; descriptor licensed by AMA)1
81400 (CPT; descriptor licensed by AMA)1
81401 (CPT; descriptor licensed by AMA)1

G0476 is neither an add-on code nor a designated primary code in the 2026 Q4 NCCI add-on edit file.

Pair counts show exposure, not the answer for one claim. Check G0476 against a second code to see whether the pair bundles and whether a modifier can separate the services.

Medicare coverage policies for G0476

No current LCD or billing and coding article lists G0476. The HCPCS coverage code C means carrier judgment, so the Medicare contractor decides coverage, and any National Coverage Determination for the service still applies.

Denials to expect on G0476

the service is not reasonable and necessary for the diagnosis on the claim

units of G0476 exceed the practitioner MUE of 1 per date of service

the modifier reported is inconsistent with the code

the claim lacks the description, invoice or pricing detail a contractor-priced code needs

Where QuickIntell fits for G0476 claims

QuickCode supports qualified coder review of units, modifiers and NCCI pairs for G0476 before the claim leaves, and QuickRCM carries claim readiness and the denial follow-up when an edit or coverage policy is missed.

Frequently asked questions: HCPCS G0476

What does HCPCS code G0476 describe?

"Infectious agent detection by nucleic acid (dna or rna); human papillomavirus (hpv), high-risk types (e.g., 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68) for cervical cancer screening, must be performed in addition to pap test" (short descriptor "Hpv combo assay ca screen"), in the G section (procedures and professional services, temporary). Added 2015-07-09.

Is G0476 a CPT code?

No. G0476 is a CMS HCPCS Level II code; CPT codes are the AMA's five-character set. Searches for "G0476 CPT code" mean this Level II code.

What does Medicare pay for G0476?

The 2026 Q4 clinical laboratory fee schedule pays G0476 $35.09 (national limitation amount).

How many units of G0476 can be billed per day?

Its 2026 Q4 MUEs per date of service: practitioner 1 (MAI 2, CMS Policy); hospital outpatient 1 (MAI 2, CMS Policy). For the practitioner MUE (MAI 2), units above 1 deny for the whole day as a policy limit; denials arrive as CARC 151.

Does Medicare cover G0476?

No current LCD or billing article lists G0476; its HCPCS coverage code is C (carrier judgment, so the Medicare contractor decides coverage).

CMS guidance

The Medicare Learning Network publication that CMS issues on this topic, cited by ICN and publication date:

Sources

Every figure on this page is taken from the CMS publications below, as released by the Centers for Medicare & Medicaid Services. Projection built 2026-10-10. Verify against the primary file before billing or contracting decisions. The reference methodology explains how each figure is computed from these files.

Disclaimer

This page is an operational reference compiled from CMS publications: the HCPCS Level II file, the physician, DMEPOS and clinical laboratory fee schedules, OPPS and ASC addenda, NCCI MUE, PTP and add-on edit tables and the Medicare Coverage Database. Amounts are Medicare national figures before locality and state adjustment; Medicaid and commercial payers set their own. CPT codes are shown as numbers only; CPT descriptors are copyright AMA. Nothing here is legal, clinical or billing advice.

Found a figure that does not match the CMS file? Report a data correction with the CMS file and the value you expected; the request reaches the editorial team through the contact form.